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Murine expression of a human IgA lambda locus

  • US 6,998,514 B2
  • Filed: 12/13/2000
  • Issued: 02/14/2006
  • Est. Priority Date: 11/03/1998
  • Status: Expired due to Term
First Claim
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1. A transgenic mouse comprising in its genome a yeast artificial chromosome (YAC), wherein the YAC contains at least a majority of the human Ig Vλ

  • genes of cluster A and all the human Ig Jλ

    -Cλ

    segments in germline configuration, wherein the proportion of the κ and

    λ

    light chains expressed by said transgenic mouse resembles that found in humans, and exhibits relative proportions of <

    60% κ

    light chains and >

    40% λ

    light chains, wherein at least one endogenous κ

    light chain locus of the transgenic mouse is not disrupted.

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