Method for treating ischemia
First Claim
1. A method of treating an ischemic region of a patient, comprising creating a concentration gradient of an angiogenesis stimulating substance in the ischemic region and/or in tissue of a region adjacent the ischemic region, wherein the concentration gradient is formed by creating a first lesion in the ischemic region or in the tissue of the region adjacent the ischemic region and creating a second lesion in the ischemic region or in the tissue of the region adjacent the ischemic region, and wherein the lesions have different sizes.
0 Assignments
0 Petitions
Accused Products
Abstract
A method and apparatus for improving blood flow to an ischemic region (e.g., myocardial ischemia) a patient is provided. An ultrasonic transducer is positioned proximate to the ischemic region. Ultrasonic energy is applied at a frequency at or above 1 MHz to create one or more thermal lesions in the ischemic region of the myocardium. The thermal lesions can have a gradient of sizes. The ultrasound transducer can have a curved shape so that ultrasound energy emitted by the transducer converges to a site within the myocardium, to create a thermal lesion without injuring the epicardium or endocardium.
92 Citations
36 Claims
- 1. A method of treating an ischemic region of a patient, comprising creating a concentration gradient of an angiogenesis stimulating substance in the ischemic region and/or in tissue of a region adjacent the ischemic region, wherein the concentration gradient is formed by creating a first lesion in the ischemic region or in the tissue of the region adjacent the ischemic region and creating a second lesion in the ischemic region or in the tissue of the region adjacent the ischemic region, and wherein the lesions have different sizes.
- 3. A method of treating an ischemic region of a patient, comprising creating a concentration gradient of an angiogenesis stimulating substance in the ischemic region and/or in tissue of a region adjacent the ischemic region, wherein the concentration of the angiogenesis stimulating substance is highest at about the center of the ischemic region.
- 7. A method of treating an ischemic region of a patient, comprising creating a concentration gradient of an angiogenesis stimulating substance in the ischemic region and/or in tissue of a region adjacent the ischemic region, wherein the concentration of the angiogenesis stimulating substance is lower in the ischemic region than in the tissue of the region adjacent the ischemic region.
- 8. A method of treating a region of ischemic tissue in a patient, comprising triggering the release of an angiogenesis stimulating substances to create a concentration variance of the angiogenesis stimulating substances in the region of ischemic tissue and/or in tissue of a region adjacent the region of ischemic tissue, wherein the concentration variance is formed by creating a first lesion in the ischemic region or in the region adjacent the ischemic region and creating a second lesion in the ischemic region or in the region adjacent the ischemic region, and wherein the lesions have different sizes.
- 10. A method of treating a region of ischemic tissue in a patient, comprising triggering the release of an angiogenesis stimulating substance to create a concentration variance of the angiogenesis stimulating substance in the region of ischemic tissue and/or in tissue of a region adjacent the region of ischemic tissue, wherein the angiogenesis stimulating substance is released by the tissue of the region adjacent to the region of ischemic tissue.
-
11. A method of treating ischemic myocardial tissue of a patient, comprising:
-
inserting into the patient a catheter having a tissue stimulating device; positioning the tissue stimulating device on or near the ischemic myocardial tissue; and stimulating the ischemic myocardial tissue and/or myocardial tissue near the ischemic myocardial tissue without piercing or cutting the myocardial tissue to trigger the release of an angiogenic factor. - View Dependent Claims (12, 13, 14, 19, 20, 21, 22, 23, 24, 25, 26)
-
-
27. A method of treating a patient, comprising:
-
inserting into the patient a catheter assembly having a tissue stimulating device; positioning the tissue stimulating device over or near a ischemic region; using the tissue stimulating device to cause the release of an angiogenic substance without piercing or cutting the tissue over which the tissue stimulating device is positioned. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36)
-
Specification