Assessment of concentration of inhalational compounds in the brain
First Claim
1. An article comprising a machine-readable medium that stores machine-executable instructions, the instructions causing a machine to:
- receive values representing the concentration of a compound administered in a gas into a subject to fill the pulmonary functional residual capacity, the values including an inspired compound concentration (Ci′
) and an expired compound concentration (Ce′
), wherein the inspired compound concentration (Ci′
) and the expired compound concentration (Ce′
) are obtained after having filled the functional residual capacity with the gas; and
output a representation of a compound concentration in the brain (Cb), in which the representation of the compound concentration in the brain (Cb) is assessed by the formula Cb=(Ce′
+Cb′
)/2, wherein Cb′
=[Ci′
(M−
1)+Ce′
]/M, M being an alveolar membrane factor for the compound.
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Abstract
This invention directs to a method of assessing the concentration of an inhalational compound in the brain of a subject. The method includes administering a gas containing the compound into a subject to fill the pulmonary functional residual capacity, which is defined as the remaining lung volume at the end of an unforced respiration. The method also includes measuring an inspired compound concentration (Ci′) and an expired compound concentration (Ce′) after having filled the functional residual capacity with the gas. Therefore, a mixed venous compound concentration (Cb′) can be assessed based on the formula Cb′=[Ci′(M−1)+Ce′]/M, in which M is an alveolar membrane factor for the compound; and a brain compound concentration (Cb) can be assessed based on the formula Cb=(Ce′+Cb′)/2.
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Citations
7 Claims
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1. An article comprising a machine-readable medium that stores machine-executable instructions, the instructions causing a machine to:
-
receive values representing the concentration of a compound administered in a gas into a subject to fill the pulmonary functional residual capacity, the values including an inspired compound concentration (Ci′
) and an expired compound concentration (Ce′
), wherein the inspired compound concentration (Ci′
) and the expired compound concentration (Ce′
) are obtained after having filled the functional residual capacity with the gas; andoutput a representation of a compound concentration in the brain (Cb), in which the representation of the compound concentration in the brain (Cb) is assessed by the formula Cb=(Ce′
+Cb′
)/2, wherein Cb′
=[Ci′
(M−
1)+Ce′
]/M, M being an alveolar membrane factor for the compound. - View Dependent Claims (2, 3)
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4. An apparatus comprising:
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a display; and a processor, the processor configured to; receive values representing the concentration of a compound administered in a gas into a subject to fill the pulmonary functional residual capacity, the values including an inspired compound concentration (Ci′
) and an expired compound concentration (Ce′
), wherein the inspired compound concentration (Ci′
) and the expired compound concentration (Ce′
) are obtained after having filled the functional residual capacity with the gas; andcontrol the display to depict a representation of a compound concentration in the brain (Cb), in which the representation of the compound concentration in the brain (Cb) is assessed by the formula Cb=(Ce′
+Cb′
)/2, whereinCb′
=[Ci′
(M−
1)+Ce′
]/M, M being an alveolar membrane factor for the compound. - View Dependent Claims (5, 6, 7)
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Specification