Microorganism strain of GM-020 ofLactobacillus rhamnosusand its use for treating obesity

• US 7,001,756 B1
• Filed: 02/19/2004
• Issued: 02/21/2006
• Est. Priority Date: 02/19/2004
• Status: Active Grant

• Current Assignee: Genmont Biotech, Inc.
• Original Assignee: Genmont Biotech, Inc.
• Inventors: Hsu, Ching-Hsiang, Su, Wei-Chih
• Primary Examiner(s): Navarro, Mark
• Assistant Examiner(s): Ford, Vanessa L.
• Application Number:
  US10/780,601
• Time in Patent Office: 733 Days
• Field of Search: 424/93.45, 424/93.1, 424/93.2, 424/184.1, 435/252.9
• US Class Current: 435/252.9
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 35/747 Lactobacilli, e.g. L. acidophilus or L. brevis
• CPC Class Codes: A61K 36/07 Basidiomycota, e.g. Cryptococcus
• CPC Class Codes: C12N 1/20 Bacteria; Culture media therefor
• CPC Class Codes: C12N 1/205 Bacterial isolates
• CPC Class Codes: C12R 2001/225 Lactobacillus

Abstract

The present invention provides an isolated microorganism strain, Lactobacillus rhamnosus GM-020, which is found to be effective in treating obesity and a complication thereof. The use of the Lactobacillus rhamnosus GM-020 in treating obesity and a complication thereof is also provided.

Claims

1. An isolated microorganism of the strain Lactobacillus rhamnosus GM-020, deposited at the China Center for Type Culture Collection under CCTCC No.:

CCTCC M 203098.

2. A composition comprising a suspension of the isolated microorganism strain according to claim 1.

3. A composition according to claim 2, which is used for treating obesity or a complication thereof, wherein the Lactobacillus rhamnosus GM-020 is gram-stain positive.

4. The composition according to claim 3 further comprising Auricularia polytricha.

5. The composition according to claim 3, comprising a dosage of Lactobacillus rhamnosus GM-020 of 10⁹ CFU/mL and wherein the complication is selected from the group consisting of hypercholesterolemia, atherosclerosis and coronary heart disease.

6. A composition for treating obesity and a complication thereof in a subject comprising the isolated microorganism according to claim 1 and Auricularia polytricha.

7. A method for treating obesity or a complication thereof in a subject comprising administrating said subject with a composition comprising the isolated microorganism according to claim 1.

8. The method according to claim 7, wherein the composition further comprises Auricularia polytricha.

9. A method for treating obesity and a complication thereof in a subject comprising administrating said subject with a composition comprising the strain according to claim 1 and Auricularia polytricha.