Compositions and methods for therapeutic use

• US 7,002,027 B1
• Filed: 07/08/1997
• Issued: 02/21/2006
• Est. Priority Date: 01/08/1996
• Status: Expired due to Fees

• Current Assignee: Canji Inc. (Merck & Co., Inc.), Schering Corporation (Merck & Co., Inc.)
• Original Assignee: Canji Inc. (Merck & Co., Inc.), Schering Corporation (Merck & Co., Inc.)
• Inventors: Engler, Heidrun, Nagabhushan, Tattanahalli L., Youngster, Stephen Kenneth
• Primary Examiner(s): Wilson, Michael C.
• Application Number:
  US08/889,355
• Time in Patent Office: 3,150 Days
• Field of Search: 514/44, 514/2.21, 424/184.1, 424/93.21, 435/455, 800/21, 552/549, 536/123.1
• US Class Current: 552/549
• CPC Class Codes: A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention is directed to compositions and methods of treating cancer by gene therapy using a therapeutic gene formulated in a buffer comprising a delivery-enhancing agent. The delivery-enhancing agents of the invention can be used to formulate therapeutic or diagnostic agents, such as proteins, nucleic acids, antisense RNA, small molecules, etc., for administration to any tissue or organ having an epithelial membrane. The delivery-enhancing agents include detergents, alcohols, surfactants and other molecules.

Claims

1. A compound of Formula I:

wherein;

n is 3;

X₁ and X₂ are both cholic acid groups;

wherein the cholic acid group has the formula;

and X₃ is a pentose monosaccharide group.

2. A compound having the formula:

3′

-N-gluconamidopropyl-3″

-N-cholamidopropyl-N-cholamide.

3. A compound of Formula I:

wherein;

n is 3;

X₁ and X₂ are both cholic acid groups;

wherein the cholic acid group has the formula;

and X₃ is a hexose monosaccharide group.