Apparatus and method for thermally cycling samples of biological material with substantial temperature uniformity
First Claim
1. An apparatus for thermally cycling samples of biological material comprising:
- a thermal block assembly including a plurality of sample holders for receiving samples of biological material;
a heat sink located below the thermal block assembly and thermally coupled to the thermal block assembly to transfer heat away from the thermal block assembly;
a first heat source located between the thermal block assembly and the heat sink, the first heat source thermally coupled to the thermal block assembly to heat the thermal block assembly; and
a second heat source located below the first heat source, wherein the second heat source is radially outside the first heat source, the second heat source thermally coupled to the first heat source to heat at least a portion of the first heat source.
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Abstract
An apparatus for thermally cycling samples of a biological material including a thermal block assembly including a plurality of sample holders for receiving samples of biological material; a heat sink thermally coupled to the thermal block assembly, the heat sink transferring heat away from the thermal block assembly to ambient air in contact with the heat sink; a first heat source thermally coupled to the thermal block assembly to provide heat to the thermal block assembly; and a second heat source thermally coupled to the first heat source and configured to provide heat to a portion of the first heat source. The arrangement of the heat sink, first heat source and second heat source can provide substantial temperature uniformity among the plurality of sample holders. The invention also includes a method for thermally cycling samples of biological material.
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Citations
47 Claims
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1. An apparatus for thermally cycling samples of biological material comprising:
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a thermal block assembly including a plurality of sample holders for receiving samples of biological material; a heat sink located below the thermal block assembly and thermally coupled to the thermal block assembly to transfer heat away from the thermal block assembly; a first heat source located between the thermal block assembly and the heat sink, the first heat source thermally coupled to the thermal block assembly to heat the thermal block assembly; and a second heat source located below the first heat source, wherein the second heat source is radially outside the first heat source, the second heat source thermally coupled to the first heat source to heat at least a portion of the first heat source. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. An apparatus for thermally cycling samples of biological material with substantial temperature uniformity comprising:
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a thermal block assembly including a plurality of sample holders for receiving samples of biological material; a first heat source located below the thermal block assembly and thermally coupled to the thermal block assembly to heat the thermal block assembly; a second heat source located below the first heat source, wherein the second heat source is radially outside the first heat source toward an edge of the thermal block assembly, the second heat source thermally coupled to the first heat source to heat at least a portion of the first heat source; and a heat sink located below the second heat source and thermally coupled to the thermal block assembly to transfer heat away from the thermal block assembly. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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43. An apparatus for thermally cycling samples of biological material comprising:
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a thermal block assembly including at least one sample holder for receiving a biological material; a heat sink located below the thermal block assembly and thermally coupled to the thermal block assembly to transfer heat from the thermal block assembly; an upper heat source located under the thermal block assembly, the upper heat source providing heat to the thermal block assembly; and a lower heat source providing heat to at least a portion of the upper heat source, the lower heat source located under the upper heat source and radially outside the upper heat source. - View Dependent Claims (44, 45, 46, 47)
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Specification