Biological imager
First Claim
Patent Images
1. A method of determining the amounts of first and second non-immiscible components in a mixture having known, different indices of refraction in the mixture comprising:
- a) passing a focused light beam through the mixture;
b) measuring the displacement of the actual point of focus from a known focal point through a material with a known index of refraction; and
c) calculating the amounts of the first and second components present from the displacement.
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Abstract
Apparatus and method for quantifying the biological components of a biological system having at least two different refractive indices through detection of wave front distortions. The biological component fractions are determined based on information gathered on their respective indices when exposed to particular wavelengths of light.
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Citations
14 Claims
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1. A method of determining the amounts of first and second non-immiscible components in a mixture having known, different indices of refraction in the mixture comprising:
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a) passing a focused light beam through the mixture; b) measuring the displacement of the actual point of focus from a known focal point through a material with a known index of refraction; and c) calculating the amounts of the first and second components present from the displacement. - View Dependent Claims (2, 3, 4, 5)
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6. A method for measuring characteristics of a biological system having at least two contrasting density components comprising:
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(a) projecting light of wavelength λ
1 through a multi-density system to distort wavefront of wavelength λ
1;(b) projecting light of wavelength λ
2 through a multi-density;(c) system to distort a wavefront of wavelength λ
2; and(d) determining biological components information in response to the distortion of the light of wavelengths λ
1 and λ
2,wherein the biological information determines the refractive index of a biological component.
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7. A method for measuring characteristics of a biological system having at least two contrasting density components comprising:
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(a) projecting light of wavelength λ
1 through a multi-density system to distort wavefront of wavelength λ
1;(b) projecting light of wavelength λ
2 through a multi-density;(c) system to distort a wavefront of wavelength λ
2; and(d) determining biological components information in response to the distortion of the light of wavelengths λ
1 and λ
2,wherein the biological information determines the ratio of biological components.
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8. A method for measuring characteristics of a biological system having at least two contrasting density components comprising:
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(a) projecting light of wavelength λ
1 through a multi-density system to distort wavefront of wavelength λ
1;(b) projecting light of wavelength λ
2 through a multi-density;(c) system to distort a wavefront of wavelength λ
2; and(d) determining biological components information in response to the distortion of the light of wavelengths λ
1 and λ
2,wherein the biological information determines both the refractive index and the ratio of biological components.
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9. A method of analyzing biological components in a system, having a plurality of contrasting density components comprising:
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a) a projecting light comprising λ
1 and λ
2 through the fluid stream such that(i) λ
1;
chosen such that NBC (λ
1)≠
Nwater (λ
1) and NBC (λ
1)≠
Nair (λ
1);(ii) λ
2;
chosen such that Nwater (λ
2)≠
Nwater (λ
2) and NBC (λ
2)≠
Nair (λ
2);b) projecting light through the system such that displacement of the focus from a known position indicates a specific biological component; c) further projecting light through an aperture and collimating lens array to an area sensor; and d) detecting the wavefront shape distortions to determine the specific biological components. - View Dependent Claims (10)
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11. A method of analyzing biological components in a system, having a plurality of contrasting density components comprising:
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a) a projecting light comprising λ
1 and λ
2 through the fluid stream such that(i) λ
1;
chosen such that NBC (λ
1)≠
Nwater (λ
1) and NBC (λ
1)≠
Nair (λ
1);(ii) λ
2;
chosen such that Nwater (λ
2)≠
Nwater (λ
2) and NBC (λ
2)≠
Nair (λ
2);b) projecting light through the system such that the focus indicates a specific biological component; c) further projecting light through an aperture and collimating lens array to an area sensor; and d) detecting the wavefront distortions to determine the specific biological components, further comprising tuning the detector to detect a plane wave when projected through water.
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12. A biological imager for measuring the biological components in a system comprising:
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a) a light source comprising wavelengths λ
1 and λ
2 such that when projected through the biological sample, produces a distinct signature due to the distortion of the wavefront; andb) detection to sense the signature, wherein a focus moves left or right to indicate more or less of a component. - View Dependent Claims (13, 14)
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Specification