Pressure sensors having transducers positioned to provide for low drift

• US 7,007,551 B2
• Filed: 12/28/2004
• Issued: 03/07/2006
• Est. Priority Date: 12/11/2003
• Status: Active Grant

• Current Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Biomedical, Inc. (Otsuka Holdings Company Limited)
• Inventors: Zdeblick, Mark, Costello, Benedict James
• Primary Examiner(s): Oen, William
• Assistant Examiner(s): Ellington, Alandra
• Application Number:
  US11/025,879
• Publication Number:
  US 20050160827A1
• Time in Patent Office: 434 Days
• Field of Search: 73700-756
• US Class Current: 73/715
• CPC Class Codes: A61B 2562/02 Details of sensors specially adapted for in-vivo measurements
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: G01L 9/0042 Constructional details associated with semiconductive diaphragm sensors, e.g. etching, or constructional details of non-semiconductive diaphragms details about the integration or bonding of piezoresistor in or on the diaphragm G01L9/0052 and G01L9/0057 respectively
• CPC Class Codes: G01L 9/0055 bonded on a diaphragm
• CPC Class Codes: G01L 9/045 with electric temperature compensating means non electric temperature compensating means G01L19/04
• CPC Class Codes: G01L 9/065 with temperature compensating means non electric temperature compensating means G01L19/04

Abstract

Implantable pressure sensors and methods for making and using the same. A feature of of at least some of the subject pressure sensors is that they are low-drift sensors. Additional features of representative pressure sensors include the presence of first and second strain transducers that are associated with a compliant member so that their outputs respond oppositely to deflection of the compliant member resulting from differential pressure across the compliant member but respond similarly to deformation of a substrate on which the compliant member is mounted. The subject pressure sensors find use in a variety of applications.

Claims

1. A pressure-sensor structure comprising:

a substrate;

a compliant member mounted on said substrate and having a first surface and a second surface;

a first strain transducer associated with said compliant member; and

a second strain transducer associated with said compliant member;

wherein said first and second strain transducers are associated with said compliant member so that their outputs respond oppositely to deflection of said compliant member resulting from differential pressure across said compliant member but respond similarly to deformation of said substrate.

2. The structure according to claim 1, wherein said structure further comprises an integrated circuit.

3. The structure according to claim 1, wherein said structure further comprises a boss member on at least one surface of said compliant member.

4. The structure according to claim 1, wherein said structure further comprises first and second boss members on opposing surfaces of said compliant member.

5. The structure according to claim 1, wherein said compliant member is positioned at least proximal to said structure'"'"'s neutral plane.

6. The structure according to claim 1, wherein at least one of said strain transducers is separated from a surface of said compliant member by a spacer.

7. The structure according to claim 1, wherein said structure exhibits a drift of no more than about 1 mmHg/year.

8. The structure according to claim 1, wherein said structure exhibits little or no drift over a period of from about 1 to about 40 years.

9. The structure according to claim 1, wherein said structure has a length along an edge of no more than about 500 μ

m and width of no more than about 100 μ

m.

10. The structure according to claim 1, wherein said structure has a sensitivity sufficient to measure pressure changes of about +/−

1 mmHg.

11. A method for detecting a pressure change in a volume, said method comprising:

contacting a pressure sensor structure according to claim 1 with said volume;

obtaining an output signal from said pressure sensor structure; and

using said output signal to detect a pressure change in said volume.

12. The structure according to claim 1, wherein said first and second strain transducers are positioned on opposing surfaces of said compliant member.

13. The structure according to claim 12, wherein said first and second strain transducers are directly opposed to each other.

14. The structure according to claim 1, wherein said structure further comprises third and fourth strain transducers on opposing surfaces of said compliant member.

15. The structure according to claim 14, wherein said structure further comprises first and second boss members on opposing surfaces of said comliant member.

16. The structure according to claim 1, wherein said first and second strain transducers are piezoresistors.

17. The structure according to claim 16, wherein said piezoresistors are fabricated from a stable gauge material.

18. The structure according to claim 1, wherein:

said first strain transducer is a first piezoresistor comprising two segments with equal nominal resistance in series disposed on a first surface of said compliant member; and

said second strain transducer is a second piezoresistor comprising two segments with equal nominal resistance in series disposed radially outwardly on said surface from said two segments of the first piezoresistor.

19. The structure according to claim 18, further comprising:

a third piezoresistor comprising two segments with equal nominal resistance in series disposed on said surface of said compliant member symmetric to said first piezoresistor; and

a fourth piezoresistor comprising two segments with equal nominal resistance in series disposed radially outwardly on said surface of said compliant member from said two segments of said third piezoresistor and symmetric to said second piezoresistor.

20. The structure according to claim 1, wherein said first and second strain transducers are positioned on the same surface of said compliant member.

21. The structure according to claim 20, wherein said first and second strain transducers are positioned symmetrically on said compliant member on opposite sides of a line of symmetry.

22. The structure according to claim 21, wherein said swain transducers are positioned adjacent to each other on one side of a line of symmetry.

23. A method for fabricating a pressure-sensor structure, said method comprising:

positioning a layer of a compliant material on a surface of a first substrate;

producing at least one strain transducer on a first surface of said compliant material opposite said substrate to produce a pressure-sensor structure to produce a pressure sensor structure according to claim 1.

24. The method according to claim 23, wherein said method further comprises producing a boss member on said first surface of said compliant layer.

25. The method according to claim 23, wherein said method further comprises coupling said structure to a conductive member.

26. The method according to claim 23, wherein said method is a microfabrication method.

27. The method according to claim 26, wherein said method comprises a photolithograpbic method.

28. A system comprising:

a conductive member; and

a pressure sensor structure according to claim 1 operatively coupled to said conductive member.

29. The system according to claim 28, wherein said system further comprises an energy source coupled to said conductive member.

30. The system according to claim 28, wherein said system further comprises a processing element for determining pressure changes in a volume in response to output signals from said first and second strain transducers.

31. The system according to claim 28, wherein said system is configured to be implanted into a patient.

32. The system according to claim 31, wherein said system is configured so that said sensor is positioned on a heart wall upon implantation into a patient.

33. The system according to claim 28, wherein said system comprises a plurality of said pressure sensor structures operatively coupled to said conductive member.

34. The method according to claim 33, wherein said volume is present in a subject.

35. The method according to claim 34, wherein said method is employed in a method of one of:

a) treating a subject for heart failure;

b) performing cardiac resynchronization in a subject;

c) managing arrhythmia in a subject;

d) detecting ischemia in a subject;

e) treating a subject for coronary artery disease;

f) monitoring heart valve function in a subject; and

g) monitoring graft function in a subject.

36. The method according to claim 34, wherein said method is a method of monitoring a condition in a subject.

37. The method according to claim 36, wherein said method comprises monitoring said condition remotely.

38. The method according to claim 36, wherein said condition is a cardiovascular condition.

39. The method according to claim 34, wherein said subject is a human.

40. The method according to claim 39, wherein said method comprises implanting said pressure sensor structure in said human.

41. The method according to claim 40, wherein said volume is a cardiovascular volume.

42. The method according to claim 41, wherein said cardiovascular volume is a heart chamber.

43. The method according to claim 41, wherein said cardiovascular volume is in an artery.