Treatment of acne
First Claim
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1. A method of treating acne conditions, the method comprising:
- contacting an acne problem area of a patient with a therapeutically effective amount of one or more antimicrobial metals in a nanocrystalline form to provide a localized antimicrobial and anti-inflammatory effect,wherein;
the one or more antimicrobial metals in nanocrystalline form have sufficient atomic disorder so that the one or more antimicrobial metals in nanocrystalline form, when in contact with an alcohol or water-based electrolyte, releases atoms, ions, molecules, or clusters of the one or more antimicrobial metals in nanocrystalline form into the alcohol or water-based electrolyte on a sustainable basis and at a concentration sufficient to provide a localized antimicrobial and anti-inflammatory effect; and
the one or more antimicrobial metals are provided as a coating on, or filler in, a dressing, or in a pharmaceutical composition with one or more pharmaceutically and dermatologically acceptable carriers, diluents or excipients suitable for topical administration.
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Abstract
The invention relates to the use of one or more antimicrobial metals selected from silver, gold, platinum, and palladium but most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of a acne. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.
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Citations
20 Claims
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1. A method of treating acne conditions, the method comprising:
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contacting an acne problem area of a patient with a therapeutically effective amount of one or more antimicrobial metals in a nanocrystalline form to provide a localized antimicrobial and anti-inflammatory effect, wherein; the one or more antimicrobial metals in nanocrystalline form have sufficient atomic disorder so that the one or more antimicrobial metals in nanocrystalline form, when in contact with an alcohol or water-based electrolyte, releases atoms, ions, molecules, or clusters of the one or more antimicrobial metals in nanocrystalline form into the alcohol or water-based electrolyte on a sustainable basis and at a concentration sufficient to provide a localized antimicrobial and anti-inflammatory effect; and the one or more antimicrobial metals are provided as a coating on, or filler in, a dressing, or in a pharmaceutical composition with one or more pharmaceutically and dermatologically acceptable carriers, diluents or excipients suitable for topical administration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of treating acne conditions, comprising:
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contacting an acne problem area of a patient with a therapeutically effective amount of a pharmaceutical composition to provide a localized antimicrobial and anti-inflammatory effect, wherein; the pharmaceutical composition comprises; an antimicrobial metal in a nanocrystalline form; and one or more pharmaceutically and dermatologically acceptable carriers, diluents or excipients suitable for topical administration; and the antimicrobial metal in nanocrystalline form has sufficient atomic disorder so that the antimicrobial metal in nanocrystalline form, when in contact with an alcohol or water-based electrolyte, releases atoms, ions, molecules, or clusters of the metal into the alcohol or water-based electrolyte on a sustainable basis and at a concentration sufficient to provide a localized antimicrobial and anti-inflammatory effect. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification