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Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods

  • US 7,008,798 B2
  • Filed: 03/22/2002
  • Issued: 03/07/2006
  • Est. Priority Date: 04/18/1986
  • Status: Expired due to Fees
First Claim
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1. A method for labeling a component of an aqueous liquid comprising:

  • a) adding to said liquid containing said component a luminescent dye selected from the group consisting of cyanine, merocyanine and styryl dyes containing at least one sulphonate or sulphonic acid attached to an aromatic nucleus which dye is reactive with said component;

    b) reacting said dye with said component so that said dye labels said component; and

    wherein said dye has a molar extinction coefficient of at least 50,000 liters per mole centimeter, a quantum yield of at least 5 percent and absorbs and emits maximally in the 400 to 900 nm range.

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