Optimization of impedance signals for closed loop programming of cardiac resynchronization therapy devices

• US 7,010,347 B2
• Filed: 06/04/2004
• Issued: 03/07/2006
• Est. Priority Date: 02/14/2004
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Schecter, Stuart O.
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US10/860,990
• Publication Number:
  US 20050182447A1
• Time in Patent Office: 641 Days
• Field of Search: 607 17- 18, 607/28, 607 4- 6, 607 8- 9, 607/30, 607/32
• US Class Current: 607/17
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36528 the parameter being measured by means of ultrasound
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

What are described herein are implantable cardiac devices such as pacemakers and defibrillators that deliver cardiac resynchronization therapy (CRT), and to a method of optimizing acquisition of impedance signals between electrodes present on implanted lead systems. This system then automatically determines which electrodes or electrode combinations acquire impedance waveforms that have the best signal to noise ratio (highest fidelity) and characterize data most representative of dysynchronous electro-mechanical events. Using closed loop algorithms which provide electrograms and a variety of impedance data reflective of the patient'"'"'s clinical status, the system autonomously modifies interval timing within the CRT device.

Claims

1. A method of programming a cardiac resynchronization therapy (CRT) device comprising:

determining a control parameter associated with dynamic intracardiac impedance data of a patient;

determining if said control parameter is acceptable; and

setting an operational parameter of said CRT based on said control parameter;

wherein said control parameter is determined by measuring the impedances along several vectors and determining said control parameter from these vectors.

2. The method of claim 1 wherein impedances are measured during several cardiac cycles using techniques of ensemble averaging.

3. The method of claim 2 wherein said control parameter is determined by summation averaging of individually derived parameters.

4. The method of claim 1 wherein acceptable control parameters are determined using multivariate statistical analysis techniques.

5. The method of claim 1 wherein said acceptable control parameters are determined by comparison to waveforms obtained previously from the patient.

6. The method of claim 1 wherein said CRT applies excitation signals to the different electrodes and analysis of said control parameter is used to direct the timing of said excitation signals to eliminate dysynchrony between or within said cardiac chambers.

7. A programming system comprising:

a cardiac resynchronization therapy (CRT) device applying therapy to a patient based on a plurality of operational parameters;

a parameter detector that detects a control parameter related to the dynamic intrathoracic impedance of the patient;

a parameter evaluator that determines if said control parameter is acceptable;

a controller that uses said control parameter to set said operational parameters based on said control parameter, if said control parameter is found acceptable;

a programmer, said parameter detector and said parameter evaluator being disposed in said programmer; and

wherein said parameter detector and said parameter evaluator are disposed in said CRT.

8. An implantable cardiac resynchronization therapy (CRT) device comprising:

a sensor that senses intrinsic cardiac events and generates corresponding sensing signals;

an excitation generator generating excitation signals for different locations of the heart in response to commands;

a controller generating said commands in accordance with a plurality of operational parameters dependent on said sensing signals;

a parameter generator generating a control parameter dependent on a thoracic impedance of the patient; and

a parameter evaluator that determines if said control parameter is acceptable based on a set of preset criteria;

wherein said control parameter is used by the controller to reduce dysynchrony between or within the cardiac chambers; and

wherein said control parameter is used by the controller to optimize cardiac performance by maximizing cardiac output.

9. The implantable CRT of claim 8 wherein said parameter generator can acquire impedance data using data sampling methodologies selected to reduce costs to the system and reduce the affect of uncontrollable inputs and measurement errors.

10. The implantable CRT of claim 8 wherein said controller delineates event timing and extrapolates this to intracardiac electrograms for reference purposes.

11. The implantable CRT of claim 8 wherein said controller is adapted to modify pacing parameters, altering tachyarrhythmia therapies and relaying relevant clinical variables to a remote location when changes in clinical status occurs.

12. A method of stimulating a patient'"'"'s heart comprising:

generating stimulation signals to the heart;

measuring a thoracic impedance of the heart by performing measurements between several implanted electrode pairs and combining said measurements to determine said impedance;

detecting a dysynchrony between a right and a left chamber from said impedance; and

adjusting the timing of said stimulation signals to reduce said dysynchrony.

13. The method of claim 12 wherein said thoracic impedance is determined by performing measurements between several implanted electrode pairs and selecting an optimal measurement.

14. A method of programming a cardiac resynchronization therapy (CRT) device comprising:

determining a control parameter associated with dynamic intracardiac impedance data of a patient;

determining if said control parameter is acceptable; and

setting an operational parameter of said CRT device based on said control parameter;

wherein acceptable control parameters are determined using multivariate statistical analysis techniques.

15. An implantable cardiac resynchronization therapy (CRT) device comprising:

a sensor that senses intrinsic cardiac events and generates corresponding sensing signals;

an excitation generator generating excitation signals for different locations of the heart in response to commands;

a controller generating said commands in accordance with a plurality of operational parameters dependent on said sensing signals;

a parameter generator generating a control parameter dependent on a thoracic impedance of the patient; and

a parameter evaluator that determines if said control parameter is acceptable based on a set of preset criteria;

wherein said control parameter is used by the controller to optimize cardiac performance by maximizing cardiac output.