Valve designs for left ventricular conduits

• US 7,011,095 B2
• Filed: 06/18/2003
• Issued: 03/14/2006
• Est. Priority Date: 09/10/1998
• Status: Expired due to Fees

• Current Assignee: Horizon Technology Funding Co. LLC (Horizon Technology Finance Management LLC)
• Original Assignee: Percardia, Inc.
• Inventors: Wilk, Peter J., Wolf, Scott J., Briefs, Nancy M.
• Primary Examiner(s): Isabella, David J.
• Application Number:
  US10/463,798
• Publication Number:
  US 20030216679A1
• Time in Patent Office: 1,000 Days
• Field of Search: 623/1.11, 623/1.12, 623/1.36, 623 142- 146, 606/153, 606/191, 606192-194, 606/198, 606/151, 606/152, 604/8, 604/9, 600 16- 18, 128/898
• US Class Current: 128/898
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61F 2/848 having means for fixation to the vessel wall, e.g. barbs
• CPC Class Codes: A61F 2/94 Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/821 Ostial stents
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61M 39/24 Check- or non-return valves

Abstract

Disclosed is a conduit that provides a bypass around a stenosis or occlusion in a coronary artery. The conduit is adapted to be positioned in the myocardium to provide a passage for blood to flow from a heart chamber to a coronary artery, at a site distal to the blockage or stenosis in the coronary artery. The conduit has a one-way valve positioned therein to prevent the backflow of blood from the coronary artery into the heart chamber.

Claims

1. A method of treating a heart, the method comprising:

providing at least one hollow implant defining a lumen and being configured to be positioned in a heart wall between a heart chamber and a coronary vessel, wherein, when the at least one hollow implant is positioned in the heart wall, the lumen at least partially defines a blood flow passage between the heart chamber and the coronary vessel, and wherein the passage is at least partially closable in response to movement of cardiac tissue during diastole so as to at least partially obstruct blood flow therethrough;

placing the at least one hollow implant in a heart wall between a heart chamber and a blood vessel; and

at least partially obstructing blood flow through the at least one hollow implant in response to movement of cardiac tissue during diastole.

2. The method of claim 1, wherein providing the at least one hollow implant includes providing a hollow tube.

3. The method of claim 1, wherein providing the at least one hollow implant wall includes providing a conduit.

4. The method of claim 1, wherein providing the at least one hollow implant includes providing a stent.

5. The method of claim 1, wherein providing the at least one hollow implant heart wall includes providing two hollow implants.

6. The method of claim 5, wherein placing two hollow implants in the heart wall includes placing the hollow implants in the heart wall such that they are separated from each other.

7. The method of claim 6, wherein a length of each of the hollow implants is less than a thickness of the heart wall.

8. The method of claim 1, further comprising permitting blood flow through the at least one hollow implant during systole.

9. The method of claim 1, wherein placing the at least one hollow implant in the heart wall includes placing the at least one hollow implant in the heart wall between a left ventricle and the blood vessel.

10. The method of claim 1, wherein placing the at least one hollow implant in the heart wall includes placing the at least one hollow implant in the heart wall between the heart chamberand a coronary artery.

11. The method of claim 1, wherein placing the at least one hollow implant in the heart wall includes placing the at least one hollow implant in the heart wall between a left ventricle and a coronary artery.

12. The method of claim 1, wherein the at least one hollow implant is adapted to permit blood to flow from the heart chamber to the blood vessel when the blood flow through the at least one hollow implant is not at least partially obstructed.

13. The method of claim 1, wherein the cardiac tissue includes the heart wall.

14. The method of claim 13, further comprising permitting portions of the heart wall proximate the implant to come together during diastole to at least partially obstruct blood flow through the at least one hollow implant.

15. The method of claim 13, further comprising permitting free portions of the heart wall to come together during diastole to at least partially obstruct the blood flow through the at least one hollow implant.

16. The method of claim 1, further comprising forming at least one irregular surface in the heart wall proximate the passage.

17. The method of claim 16, wherein forming the at least one irregular surface in the heart wall includes one of cutting, lasing, and ablating the heart wall.

18. The method of claim 16, wherein the blood flow through the at least one hollow implant is at least partially obstructed in response to movement of the at least one irregular surface during diastole.

19. The method of claim 1, wherein the blood flow through the at least one hollow implant is fully obstructed in response to movement of the cardiac tissue during diastole.

20. A method of treating a heart, the method comprising:

providing at least one hollow implant defining a lumen, the at least one hollow implant being configured to be positioned in a heart wall between a heart chamber and a coronary vessel, wherein, when the at least one hollow implant is positioned in the heart wall, the lumen at least partially defines a blood flow passage between the heart chamber and the coronary vessel, and wherein the passage is at least partially closable by cardiac tissue entering the passage so as to at least partially obstruct blood flow therethrough during at least a portion of a cardiac cycle;

placing the at least one hollow implant in a heart wall between a heart chamber and a blood vessel; and

during at least a portion of a cardiac cycle, at least partially obstructing blood flow through the at least one hollow implant with cardiac tissue.

21. The method of claim 20, wherein providing the at least one hollow implant includes providing a hollow tube.

22. The method of claim 20, wherein providing the at least one hollow implant includes placing providing a conduit.

23. The method of claim 20, wherein providing the at least one hollow implant includes providing a stent.

24. The method of claim 20, wherein providing the at least one hollow implant includes providing two hollow implants.

25. The method of claim 24, wherein placing two hollow implants in the heart wall includes placing the hollow implants in the heart wall such that they are separated from each other.

26. The method of claim 25, wherein a length of each of the hollow implants is less than a thickness of the heart wall.

27. The method of claim 20, further comprising permitting blood flow through the at least one hollow implant during systole.

28. The method of claim 20, wherein placing the at least one hollow implant in the heart wall includes placing the at least one hollow implant in the heart wall between a left ventricle and the blood vessel.

29. The method of claim 20, wherein placing the at least one hollow implant in the heart wall includes placing the at least one hollow implant in the heart wall between the heart chamber and a coronary artery.

30. The method of claim 20, wherein placing the at least one hollow implant in the heart wall includes placing the at least one hollow implant in the heart wall between a left ventricle and a coronary artery.

31. The method of claim 30, wherein the at least one hollow implant is adapted to permit blood to flow from the left ventricle to the coronary artery when the blood flow through the at least one hollow implant is not at least partially obstructed.

32. The method of claim 20, wherein the cardiac tissue includes the heart wall.

33. The method of claim 32, wherein portions of the heart wall proximate the implant come together during diastole to at least partially obstruct blood flow through the at least one hollow implant.

34. The method of claim 32, wherein free portions of the heart wall come together during at least a portion of the cardiac cycle to at least partially obstruct the blood flow through the at least one hollow implant.

35. The method of claim 20, further comprising forming at least one irregular surface in the heart wall proximate the passage.

36. The method of claim 35, wherein forming the at least one irregular surface in the heart wall includes one of cutting, lasing, and ablating the heart wall.

37. The method of claim 35, wherein the at least one irregular surface at least partially obstructs the blood flow through the at least one hollow implant during at least a portion of the cardiac cycle.

38. The method of claim 20, wherein at least partially obstructing the blood flow through the at least one hollow implant with the cardiac tissue includes fully obstructing the blood flow through the at least one hollow implant with the cardiac tissue.

39. The method of claim 20, wherein the blood flow through the at least one hollow implant is at least partially obstructed during diastole.

40. A method for treating a heart, comprising:

positioning a hollow implant in a heart wall between a heart chamber and a coronary vessel so as to support a blood flow passage between the heart chamber and the coronary vessel, the hollow implant having an interior wall surface defining a lumen; and

moving portions of the interior wall surface relative to each other such that, during diastole, the portions reduce a cross-sectional area of the lumen so as to at least partially obstruct blood flow through the implant.

41. The method of claim 40, wherein the hollow implant is configured such that, when positioned in the heart wall, the lumen has a greater cross-sectional area during systole than during diastole at a location of the portions.

42. The method of claim 40, wherein the hollow implant includes a hollow tube.

43. The method of claim 40, wherein the hollow implant includes a stent.

44. The method of claim 40, wherein positioning the hollow implant includes positioning the hollow implant in the heart wall between a left ventricle and a blood vessel.

45. The method of claim 40, wherein positioning the hollow implant includes positioning the hollow implant in the heart wall between the heart chamber and a coronary artery.

46. The method of claim 40, wherein positioning the hollow implant includes positioning the hollow implant in the heart wall between a left ventricle and a coronary artery.

47. The method of claim 40, further comprising biasing the portions of the interior wall surface toward each other during diastole via a mechanism positioned within the wall of the conduit.

48. The method of claim 47, wherein the mechanism is chosen from springs, inflatable structures, and means responsive to electrical and/or mechanical signals.

49. The method of claim 47, wherein the mechanism is configured to permit the interior wall surface portions to move away from each other during systole.

50. The method of claim 40, wherein other portions of the interior wall surface are substantially immovable such that, during the cardiac cycle, the other portions maintain a substantially constant cross-sectional area of the lumen.