Methods for computing rolling analyte measurement values, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods
First Claim
1. A method of increasing the number of analyte measurement values related to the amount or concentration of an analyte in a subject as measured using an analyte monitoring device, said method comprisingproviding a series of analyte-related signals obtained from the analyte monitoring device over time, wherein (a) two or more contiguous analyte-related signals are used to obtain a single analyte measurement value (M), (b) analyte-related signals are not used to calculate more than one analyte measurement value, and (c) said two or more contiguous analyte-related signals, used to obtain the single analyte measurement value, comprise first and last analyte-related signals of the series;
- mathematically computing rolling analyte measurement values, wherein (i) each rolling analyte measurement value is calculated based on two or more contiguous analyte-related signals from the series of analyte-related signals obtained from the analyte monitoring device, (ii) a subsequent rolling analyte measurement value is mathematically computed by dropping said first analyte-related signal and including an analyte-related signal contiguous and subsequent to the last analyte-related signal, (iii) further rolling analyte measurement values are obtained by repeating the dropping of the first analyte-related signal used to calculate the previous rolling analyte measurement and including an analyte-related signal contiguous and subsequent to the last analyte-related signal used to calculate the previous rolling analyte measurement, and (iv) each rolling analyte measurement value provides a measurement related to the amount or concentration of analyte in the subject; and
increasing the number of analyte measurement values derived from the analyte-related signals in the series of analyte-related signals obtained from the analyte monitoring device by serially calculating rolling analyte measurement values, thereby increasing the number of analyte measurement values relative to the number of analyte measurement values provided when two or more contiguous analyte-related signals are used to obtain a single analyte measurement value (M) and analyte-related signals are not used to calculate more than one analyte measurement value.
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Abstract
The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and/or sampling device, and monitoring systems employing the methods described herein.
784 Citations
43 Claims
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1. A method of increasing the number of analyte measurement values related to the amount or concentration of an analyte in a subject as measured using an analyte monitoring device, said method comprising
providing a series of analyte-related signals obtained from the analyte monitoring device over time, wherein (a) two or more contiguous analyte-related signals are used to obtain a single analyte measurement value (M), (b) analyte-related signals are not used to calculate more than one analyte measurement value, and (c) said two or more contiguous analyte-related signals, used to obtain the single analyte measurement value, comprise first and last analyte-related signals of the series; -
mathematically computing rolling analyte measurement values, wherein (i) each rolling analyte measurement value is calculated based on two or more contiguous analyte-related signals from the series of analyte-related signals obtained from the analyte monitoring device, (ii) a subsequent rolling analyte measurement value is mathematically computed by dropping said first analyte-related signal and including an analyte-related signal contiguous and subsequent to the last analyte-related signal, (iii) further rolling analyte measurement values are obtained by repeating the dropping of the first analyte-related signal used to calculate the previous rolling analyte measurement and including an analyte-related signal contiguous and subsequent to the last analyte-related signal used to calculate the previous rolling analyte measurement, and (iv) each rolling analyte measurement value provides a measurement related to the amount or concentration of analyte in the subject; and increasing the number of analyte measurement values derived from the analyte-related signals in the series of analyte-related signals obtained from the analyte monitoring device by serially calculating rolling analyte measurement values, thereby increasing the number of analyte measurement values relative to the number of analyte measurement values provided when two or more contiguous analyte-related signals are used to obtain a single analyte measurement value (M) and analyte-related signals are not used to calculate more than one analyte measurement value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. One or more microprocessors comprising programming to:
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control mathematical computation of rolling analyte measurement values, wherein (i) each rolling analyte measurement value is calculated based on two or more contiguous analyte-related signals from a series of analyte-related signals obtained from an analyte monitoring device, (ii) said series of analyte-related signals is obtained from the analyte monitoring device over time, wherein (a) two or more contiguous analyte-related signals are used to obtain a single analyte measurement value (M), (b) analyte-related signals are not used to calculate more than one analyte measurement value, and (c) said two or more contiguous analyte-related signals, used to obtain the single analyte measurement value, comprise first and last analyte-related signals of the series, (iii) a subsequent rolling analyte measurement value is mathematically computed by dropping said first analyte-related signal and including an analyte-related signal contiguous and subsequent to the last analyte-related signal, (iv) further rolling analyte measurement values are obtained by repeating the dropping of the first analyte-related signal used to calculate the previous rolling analyte measurement and including an analyte-related signal contiguous and subsequent to the last analyte-related signal used to calculate the previous rolling analyte measurement, and (v) each rolling analyte measurement value provides a measurement related to the amount or concentration of analyte in the subject; and increase the number of analyte measurement values derived from the analyte-related signals in the series of analyte-related signals obtained from the analyte monitoring device by serially calculating rolling analyte measurement values, thereby increasing the number of analyte measurement values relative to the number of analyte measurement values provided when two or more contiguous analyte-related signals are used to obtain a single analyte measurement value (M) and analyte-related signals are not used to calculate more than one analyte measurement value. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. An analyte monitoring device comprising:
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a sensing device; and one or more microprocessor programmed to control operation of said sensing device, and control mathematical computations of rolling analyte measurement values, wherein (i) each rolling analyte measurement value is calculated based on two or more contiguous analyte-related signals from a series of analyte-related signals obtained from an analyte monitoring device, (ii) said series of analyte-related signals is obtained from the analyte monitoring device over time, wherein (a) two or more contiguous analyte-related signals are used to obtain a single analyte measurement value (M), (b) analyte-related signals are not used to calculate more than one analyte measurement value, and (c) said two or more contiguous analyte-related signals, used to obtain the single analyte measurement value, comprise first and last analyte-related signals of the series, (iii) a subsequent rolling analyte measurement value is mathematically computed by dropping said first analyte-related signal and including an analyte-related signal contiguous and subsequent to the last analyte-related signal, (iv) further rolling analyte measurement values are obtained by repeating the dropping of the first analyte-related signal used to calculate the previous rolling analyte measurement and including an analyte-related signal contiguous and subsequent to the last analyte-related signal used to calculate the previous rolling analyte measurement, and (v) each rolling analyte measurement value provides a measurement related to the amount or concentration of analyte in the subject increasing the number of analyte measurement values derived from the analyte-related signals in the series of analyte-related signals obtained from the analyte monitoring device by serially calculating rolling analyte measurement values, thereby increasing the number of analyte measurement values relative to the number of analyte measurement values provided when two or more contiguous analyte-related signals are used to obtain a single analyte measurement value (M) and analyte-related signals are not used to calculate more than one analyte measurement value. - View Dependent Claims (38, 39, 40, 41, 42, 43)
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Specification