Dilating and support apparatus with disease inhibitors and methods for use

• US 7,011,654 B2
• Filed: 02/12/2001
• Issued: 03/14/2006
• Est. Priority Date: 04/27/1998
• Status: Active Grant

• Current Assignee: Ethicon Endo-Surgery, Inc. (Johnson & Johnson)
• Original Assignee: Artemis Medical, Inc. (Johnson & Johnson)
• Inventors: Dubrul, William Richard, Fulton, Richard E
• Primary Examiner(s): Lucchesi, Nicholas D.
• Assistant Examiner(s): WILLIAMS, CATHERINE SERKE
• Application Number:
  US09/781,721
• Publication Number:
  US 20010027307A1
• Time in Patent Office: 1,856 Days
• Field of Search: 604/96.01, 604/500, 604/501, 604/20, 604/507, 604/508, 604/509, 604/103.01, 604/103.02, 60410305-10309, 604/104, 604107-109, 604/21, 606/200, 606191-192, 606/194, 623/1.11, 623 142- 143, 623 145- 146
• US Class Current: 604/508
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2025/1081 having sheaths or the like for covering the balloon but not forming a permanent part of the balloon, e.g. retractable, dissolvable or tearable sheaths
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61M 25/104 used for angioplasty
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation

Abstract

A dilating and support apparatus with disease inhibitors and methods for use is disclosed that is particularly useful for repairing and/or serving as a conduit for body passageways that require reinforcement, dilatation, disease prevention or the like. Such apparatuses are utilized to deliver a therapy, that therapy being from a family of devices, drugs, or any of a variety of other elements to a specific location within the body. The instant disclosure provides a system of combining a novel radial deployment and/or drug delivery therapy with existing balloon dilatation therapy into one device. This combination will yield a significant decrease in cost to the healthcare system as well as providing a therapy to the patient with increased safety and efficacy. Further, the instant invention provides a novel and improved platform for synthetic/tissue interface between the device and the body.

Claims

1. A method for dispensing an agent into body tissue defining a passageway of a body for treatment of cardiovascular disease comprising:

positioning a porous tubular braid having individual yarns, comprising a contact-dispensable agent in contact with all of the individual yarns, at a target site within the passageway of the body the porous tubular braid defining an open interior;

expanding the tubular braid against the body tissue by a separate radially-expandable element within the open interior or the tubular braid causing the tubular braid to make intimate contact with the body tissue;

dispensing the agent from the tubular braid into the body tissue;

contracting the radially-expandable element and the tubular braid from the body, and

removing the radially-expandable element and the tubular braid from the body.

2. The method according to claim 1 wherein the expanding step is carried out using a balloon.

3. The method according to claim 1 further comprising:

selecting an absorbent fiber tubular braid;

selecting the agent; and

applying the agent to the absorbed fibers of the tubular braid prior to the positioning step.

4. The method according to claim 1 wherein the dispensing step is carried out as a result of the expanding step.

5. The method according to claim 1 wherein the positioning step is carried out using a porous tubular braid which is not bioabsorbable.

6. A method for dispensing an agent into body tissue defining a passageway of a body for treatment of cardiovascular disease comprising:

positioning a porous tubular braid, having individual yarns, comprising a contact-dispensable agent in contact with all of the individual yarns, at a target site within the passageway of the body the porous tubular braid defining an open interior;

expanding the tubular braid against the body tissue by a separate radially-expandable element within the open interior of the tubular braid causing the tubular braid to make intimate contact with the body tissue;

dispensing the agent from the tubular braid into the body tissue, the dispensing step being carried out using lontophoresis; and

removing the radially-expandable element and the tubular braid from the body.