Methods and apparatus for remodeling an extravascular tissue structure

• US 7,011,682 B2
• Filed: 08/05/2003
• Issued: 03/14/2006
• Est. Priority Date: 01/31/2000
• Status: Expired due to Term

• Current Assignee: Edwards Lifesciences AG (Edwards Lifesciences Corporation)
• Original Assignee: Edwards Lifesciences AG (Edwards Lifesciences Corporation)
• Inventors: Taylor, David, Birdsall, Matthew, Lashinski, Randall, Lau, Jan
• Primary Examiner(s): Isabella, David J.
• Assistant Examiner(s): Chattopadhyay, Urmi
• Application Number:
  US10/634,655
• Publication Number:
  US 20040153146A1
• Time in Patent Office: 952 Days
• Field of Search: 623/2.36, 623/2.37, 623/1.1, 623/2.1, 623/11.11, 623/1.11, 623/12, 623/902, 623/66.1, 600/37, 128/898, 606/108, 606/191, 606/194, 604/528
• US Class Current: 623/2.37
• CPC Class Codes: A61F 2/2451 Inserts in the coronary sinus for correcting the valve shape
• CPC Class Codes: A61F 2/2466 Delivery devices therefor

Abstract

A medical apparatus and method for remodeling a mitral valve annulus adjacent to the coronary sinus includes an elongate body having a proximal end and a distal end. The elongate body is movable from a first, flexible configuration for transluminal delivery to at least a portion of the coronary sinus to a second configuration for remodeling the mitral valve annulus.

Claims

1. A medical apparatus for remodeling a mitral valve annulus adjacent to the coronary sinus, comprising:

an elongate body, having a proximal end and a distal end, the elongate body being movable from a first, flexible configuration for transluminal delivery to at least a portion of the coronary sinus to a second configuration for remodeling the mitral valve annulus; and

a forming element attached to the elongate body for manipulating the elongate body from the first delivery configuration to the second remodeling configuration;

wherein the elongate body in the remodeling configuration comprises proximal and distal segments which are each concave in a first direction and a central segment which is concave in a second direction and wherein at least in the remodeling configuration the forming element extends outside the body along the central segment.

2. A medical apparatus as in claim 1, wherein the elongate body comprises a tube having a plurality of transverse slots therein.

3. A medical apparatus as in claim 1, further comprising a lock for retaining the body in the remodeling configuration.

4. A medical apparatus as in claim 1, wherein the apparatus is movable from the delivery configuration to the remodeling configuration in response to proximal retraction of at least a portion of the forming element.

5. A medical apparatus as in claim 1, wherein the apparatus is movable from the delivery configuration to the remodeling configuration in response to distal advancement of at least a portion of the forming element.

6. A medical apparatus as in claim 1, further comprising at least one anchor for engaging a site within a vessel.

7. A medical apparatus as in claim 6, wherein the anchor comprises at least one barb for piercing the wall of the vessel.

8. A medical apparatus as in claim 6, comprising a first tissue anchor at the proximal end and a second tissue anchor at the distal end.

9. A medical apparatus as in claim 1, wherein the apparatus has an axial length of no more than about 10 cm.

10. A medical apparatus as in claim 9, wherein the maximum cross sectional dimension through the apparatus is no more than about 10 mm.

11. An implant for positioning within a patient, comprising:

a deployment catheter;

an elongate flexible body having a proximal section, a central section and a distal section;

a forming element extending through at least the proximal and distal sections of the body; and

a detachable coupling on the body, for removably attaching the body to the deployment catheter;

wherein manipulation of the forming element deflects the central section laterally with respect to at least a portion of the proximal and distal sections to selectively apply a compressive force along a region of tissue.

12. An implant as in claim 11, wherein the body comprises a tubular wall.

13. An implant as in claim 12, wherein the tubular wall is substantially noncompressible along a first side of the central section.

14. An implant as in claim 13 comprising a plurality of voids in the wall along a second side of the central section, thereby permitting axial shortening or elongation of the second side.

15. An implant as in claim 14 wherein at least some of the voids comprise slots through the wall, extending generally transverse to a longitudinal axis.

16. An implant as in claim 15 comprising at least 10 transverse slots in the wall of the second side.

17. An implant as in claim 16 comprising at least 20 transverse slots in the wall of the second side.

18. An implant as in claim 11, wherein the forming element comprises an axially movable element.

19. An implant as in claim 18, wherein the forming element comprises a pull wire.

20. An implant as in claim 11, wherein manipulation of the forming element introduces a first curve in the central section of the body which is concave in a first direction, and at least a second curve in one of the proximal and distal sections of the body concave in a second direction.

21. An implant as in claim 20, wherein manipulation of the forming element reshapes the body into a “

w”

configuration.

22. An implant as in claim 11, wherein the detachable coupling comprises a rotatable coupling disposed along the proximal section of the flexible body for removable attachment to the deployment catheter.

23. An implant as in claim 22, wherein the deployment catheter further comprises a rotatable driver along a distal end for removable attachment to the rotatable coupling and wherein rotation of the rotatable driver produces axial movement of the forming element relative to the flexible body.