Biochemically balanced peritoneal dialysis solutions
First Claim
1. A peritoneal dialysis solution including bicarbonate at a level of less than or equal to 30 mM/L, having a carbon dioxide partial pressure that is less than 60 mmHg and including a weak acid at a level of between approximately 15 mEq/L and approximately 20 mEq/L selected from the group consisting of:
- lactate;
citrate;
isocitrate;
cis-aconitase;
α
-ketoglutarate;
succinate;
fumarate;
malate; and
oxaloacetate.
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Abstract
A peritoneal dialysis solution that is biochemically balanced to correct metabolic acidosis associated with chronic renal failure in a more physiological manner. The peritoneal dialysis solution has a physiological pH, e.g., pH of 7.0 to 7.4, and contains bicarbonate at a concentration that is found in normal blood. Additionally, the solution contains carbon dioxide at a partial pressure that is similar to partial pressure of carbon dioxide found in normal blood. The peritoneal dialysis solution also contains a weak acid with a pKa of less than 5.0.
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Citations
15 Claims
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1. A peritoneal dialysis solution including bicarbonate at a level of less than or equal to 30 mM/L, having a carbon dioxide partial pressure that is less than 60 mmHg and including a weak acid at a level of between approximately 15 mEq/L and approximately 20 mEq/L selected from the group consisting of:
- lactate;
citrate;
isocitrate;
cis-aconitase;
α
-ketoglutarate;
succinate;
fumarate;
malate; and
oxaloacetate. - View Dependent Claims (2, 3, 4, 5)
- lactate;
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6. A peritoneal dialysis solution comprising:
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Dextrose (hydrous) (g/dl)
1.5–
4.25Sodium (mEq/L) 100–
140Chloride (mEq/L)
70–
110Calcium (mEq/L) 0.0–
4.0Magnesium (mEq/L) 0.0–
4.0Bicarbonate (mEq/L) 20.0–
30.0Weak acid (mEq/L) 10.0–
20.0wherein the weak acid is chosen from the group consisting of;
lactate;
citrate;
isocitrate;
cis-aconitase;
α
-ketoglutarate;
succinate;
fumarate;
malate; and
oxaloacetate, the solution having a carbon dioxide partial pressure that is less than 60 mmHg.- View Dependent Claims (7, 8, 9)
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10. A peritoneal dialysis solution comprising:
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Dextrose (hydrous) (g/dl)
1.5–
4.25Sodium (mEq/L) 100–
140Chloride (mEq/L)
70–
110Calcium (mEq/L) 0.0–
4.0Magnesium (mEq/L) 0.0–
4.0Bicarbonate (mEq/L) 20.0–
30.0Weak acid (mEq/L) 10.0–
20.0wherein the weak acid is chosen from the group consisting of;
lactate;
citrate;
isocitrate;
cis-aconitase;
α
-ketoglutarate;
succinate;
fumarate;
malate; and
oxaloacetate, and the solution has a carbon dioxide partial pressure that is substantially similar to the carbon dioxide partial pressure of a normal subject'"'"'s blood and the solution has a pH of approximately 7.0 to about 7.4.
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11. A method for correcting metabolic acidosis in a dialysis patient suffering or likely to suffer from same comprising the step of:
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administering to a patient a peritoneal dialysis solution that has a bicarbonate level and carbon dioxide partial pressure that are substantially similar to that found in the normal persons blood wherein the solution comprises;
Dextrose (hydrous) (g/dl)
1.5–
4.25Sodium (mEq/L) 100–
140Chloride (mEq/L)
70–
110Calcium (mEq/L) 0.0–
4.0Magnesium (mEq/L) 0.0–
4.0Bicarbonate (mEq/L) 20.0–
30.0Weak acid (mEq/L) 10.0–
20.0wherein the weak acid is chosen from the group consisting of;
lactate;
citrate;
isocitrate;
cis-aconitase;
α
-ketoglutarate;
succinate;
fumarate;
malate; and
oxaloacetate. - View Dependent Claims (12, 13, 14, 15)
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Specification