Trackable optical discs with concurrently readable nonoperational features

• US 7,014,815 B1
• Filed: 05/11/1999
• Issued: 03/21/2006
• Est. Priority Date: 10/30/1998
• Status: Expired due to Fees

• Current Assignee: Vindur Technologies, Inc.
• Original Assignee: Burstein Technologies, Inc., Nagaoka & Co., Ltd.
• Inventors: Worthington, Mark O., Virtanen, Jorma
• Primary Examiner(s): Le, Long V.
• Assistant Examiner(s): YANG, NELSON C
• Application Number:
  US09/311,329
• Time in Patent Office: 2,506 Days
• Field of Search: 369/124.07, 369/47.22, 369/275.1, 369/103, 435/6, 435/287.2, 436/518, 360/72.1, 360/75, 422/119, 422/82.05, 432/297
• US Class Current: 422/82.05
• CPC Class Codes: B01L 2300/0636 Integrated biosensor, microarrays
• CPC Class Codes: B01L 2300/0806 Standardised forms, e.g. compact disc [CD] format
• CPC Class Codes: B01L 2300/168 Specific optical properties, e.g. reflective coatings
• CPC Class Codes: B01L 2400/0409 centrifugal forces
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00
• CPC Class Codes: G01N 35/00069 whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk

Abstract

Design, manufacture and use of optical discs that permit the concurrent and discriminable acquisition of signals from both operational features and nonoperational features is presented. The disc geometries and tracking schemes permit such discs to be read in, and data encoded by nonoperational features reported by, standard (or minimally-modified), optical disc readers. Single data layer first and second surface discs are described, as are multiple data layer discs. Use of the disks in analyte-specific assay is presented.

Claims

1. A trackable optical disc, comprising:

a first reflective surface comprising a wobble groove trackable by an optical disc reader; and

a plurality of analyte-specific signal elements disposed readably with said wobble groove, said plurality of analyte-specific signal elements arranged in a pattern to thereby function as encoded data,

wherein said plurality of analyte-specific signal elements are disposed substantially confocally with said wobble groove such that they are readable by an optical head of the optical disc reader concurrently with said wobble groove.

2. The trackable optical disc of claim 1 wherein said plurality of analyte-specific signal elements and said wobble groove are disposed to produce a signal readable by a single optical pickup of the optical disc reader.

3. The trackable optical disc of claim 1 wherein said wobble groove is radially disposed.

4. The trackable optical disc of claim 1 wherein said plurality of analyte-specific signal elements are disposed with said wobble groove such that a signal from an analyte-specific signal element of said plurality of analyte-specific signal elements is detectable as an amplitude variation in an HF signal generated by tracking said wobble groove with a laser from an optical disc reader reading said optical disc.

5. The trackable optical disc of claim 1 further comprising a first solid substrate, said first reflective surface and said wobble groove being disposed upon the same side of said first solid substrate.

6. The trackable optical disc of claim 5 wherein said plurality of analyte-specific signal elements are disposed on said first reflective surface of said disc substrate on the side of said first reflective surface opposite of said first solid substrate.

7. The trackable optical disc of claim 5 further comprising a light transmissible coating applied to said first reflective surface opposite of said first solid substrate, wherein said plurality of analyte-specific signal elements are disposed upon said light transmissible coating on the side of the light transmissible coating opposite to said first reflective surface.

8. The trackable optical disc of claim 1 wherein said first reflective surface holographically projects a readable image of said wobble groove when illuminated.

9. The trackable optical disc of claim 1 wherein said analyte-specific signal element includes an antibody.

10. The trackable optical disc of claim 1 wherein said analyte-specific signal element includes a nucleic acid.

11. The trackable optical disc of claim 1 wherein said analyte-specific signal element is a cell.