Prevention and treatment of amyloidogenic disease
First Claim
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1. A method of therapeutically treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an immunogenic Aβ
fragment in a regime effective to induce an immune response comprising antibodies to the Aβ
fragment and thereby therapeutically treat the disease in the patient; and
monitoring the patient for the immune response, wherein the monitoring comprises detecting antibodies having Aβ
binding specificity.
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer'"'"'s disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
202 Citations
63 Claims
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1. A method of therapeutically treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an immunogenic Aβ
fragment in a regime effective to induce an immune response comprising antibodies to the Aβ
fragment and thereby therapeutically treat the disease in the patient; and
monitoring the patient for the immune response, wherein the monitoring comprises detecting antibodies having Aβ
binding specificity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
- in a patient, comprising;
-
32. A method of prophylaxis of a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an immunogenic Aβ
fragment in a regime effective to induce an immune response comprising antibodies to the Aβ
fragment and thereby effect prophylaxis of the disease in the patient; and
monitoring the patient for the immune response, wherein the monitoring comprises detecting antibodies having Aβ
binding specificity. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
- in a patient, comprising;
Specification