Electrokinetic delivery system for self-administration of medicaments and methods therefor

• US 7,016,724 B2
• Filed: 12/01/2003
• Issued: 03/21/2006
• Est. Priority Date: 03/10/2000
• Status: Expired due to Fees

• Current Assignee: Nitric Biotherapeutics, Inc.
• Original Assignee: Transport Pharmaceuticals, Inc. (NB Therapeutics)
• Inventors: Goldberg, Dennis I., Henley, Julian L., Potter, Joseph, Chang, Kuo Wei
• Primary Examiner(s): Bennett, Henry
• Assistant Examiner(s): NGUYEN, CAMTU TRAN
• Application Number:
  US10/724,160
• Publication Number:
  US 20040111051A1
• Time in Patent Office: 841 Days
• Field of Search: 604 19- 21, 604/501, 607/148, 607/149, 607/152, 607/153
• US Class Current: 604/20
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual'"'"'s finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual'"'"'s finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual'"'"'s finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual'"'"'s body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

Claims

1. An electrokinetic delivery system for self-administration of a medicament to a treatment site, comprising:

an applicator having a self-contained power source, processing circuitry, an active electrode on one side of said applicator and a counter electrode on an opposite side of said applicator, said power source, circuitry and said electrode lying in electrical contact with one another;

a touch-sensitive switch on the applicator whereby, upon application of the applicator to a treatment site with the medicament or a carrier therefor interposed between the applicator and the treatment site, and application of an individual'"'"'s finger to said counter electrode to activate the touch-sensitive switch and to maintain the applicator against the treatment site, completion of an electrical circuit through the active electrode, the medicament or a carrier thereof, the treatment site, the individual'"'"'s body including the finger overlying the counter electrode causes an electrical current to flow for electrokinetically driving the medicament into the treatment site.

2. A system according to claim 1 wherein said applicator contains the medicament.

3. A system according to claim 1 wherein said applicator contains the medicament and said carrier, said carrier comprising conductive hydration fluid.

4. A system according to claim 1 including an LED carried by said applicator for indicating activation of the applicator.

5. A system according to claim 1 including a vibrator responsive to activation of the applicator to indicate a working status of the applicator.

6. A system according to claim 1 wherein said applicator contains the medicament and a seal releasably attached to the applicator to seal the medicament.

7. A system according to claim 1 wherein the active electrode is located on one side of the applicator and a tacky substance is located on the opposite side of the applicator to facilitate manipulation and application of the applicator to the treatment site.

8. A system according to claim 1 wherein the active electrode is located on one side of the applicator and an electrically conductive material is located on the opposite side of the applicator to enable electrical interconnection between the individual'"'"'s finger and the counter electrode.

9. A system according to claim 8 wherein said electrically conductive material is a tacky substance to facilitate manipulation and application of the applicator to the treatment site.

10. A system according to claim 1 wherein said active electrode, said processing circuitry and said counter electrode are stacked in registration with one another with said active and counter electrodes lying alone respective opposite sides of said applicator.

11. A system according to claim 10 including a medicament on one side of the applicator and a tacky substance located on an opposite side of said applicator with said medicament and said tacky substance being stacked in registration with said electrodes and said processing circuitry and disposed along said opposite sides of said applicator, respectively.

12. A system according to claim 10 including a medicament on one side of the applicator and an electrically conductive material located on the opposite side of said applicator, said medicament, said electrically conductive material and said touch-sensitive switch being stacked in registration with said electrodes and said processing circuitry.

13. A system according to claim 12 wherein said electrically conductive material is a tacky substance to facilitate manipulation and application of the applicator to the treatment site.

14. A system according to claim 1 wherein said processing circuitry includes at least one of a microprocessor, a microcontroller, an ASIC, or a programmable logic array, and a medicament on one side of the applicator and an electrically conductive material located on the opposite side of said applicator, said medicament and said electrically conductive material being stacked in registration with said electrodes and said processing circuitry and disposed along opposite sides of said applicator, respectively.

15. A method of treatment by electrokinetic self-administration of a medicament into a treatment site for an individual, comprising the steps of:

(a) providing an applicator having a self-contained power supply, an active electrode on one side of the applicator and a counter electrode spaced from the active electrode and lying along an opposite side of said applicator, said active electrode, counter electrode and power supply being electrically coupled to one another;

(b) applying the applicator to the treatment site;

(c) placing a finger for electrical contact with the counter electrode on said opposite side of the applicator remote from the one side thereof to complete an electric circuit through the individual'"'"'s finger, the treatment site, medicament interposed between the active electrode and the treatment site, the active electrode and the counter electrode thereby to electrokinetically drive the medicament into the treatment site.

16. A method according to claim 15 including providing a pad on the applicator on said one side thereof containing the medicament.

17. A method according to claim 15 including providing a pad on the applicator on said one side thereof containing the medicament and a hydrating fluid.

18. A method according to claim 15 including enabling the applicator for one-time use only.

19. A method according to claim 15 including electrically enabling the electrical circuit by providing and pressing a touch-sensitive switch on the applicator.

20. A method according to claim 15 wherein step (a) includes stacking a medicament, said active electrode, said self-contained power supply, said counter electrode and at least one of a tacky substance or an electrically conductive material in registration one over the other with said active and counter electrodes lying along respective opposite sides of the applicator.

21. A method according to claim 15 wherein step (a) includes providing a tacky substance on the side of the applicator remote from the one side thereof to facilitate manipulation and application of the applicator to the treatment site by the individual.

22. A method according to claim 15 wherein step (a) includes providing an electrically conductive material on the side of the applicator remote from the one side thereof to facilitate electrical contact between the individual'"'"'s finger and the ground electrode.