Apparatus and methods for mixing two components

• US 7,018,089 B2
• Filed: 09/10/2003
• Issued: 03/28/2006
• Est. Priority Date: 09/17/2002
• Status: Expired due to Term

• Current Assignee: Kyphon SARL (Medtronic Plc)
• Original Assignee: Kyphon Incorporated (Medtronic Plc)
• Inventors: Sand, Paul M., Wenz, Robert
• Primary Examiner(s): SORKIN, DAVID L
• Application Number:
  US10/660,465
• Publication Number:
  US 20040122359A1
• Time in Patent Office: 930 Days
• Field of Search: 604 82- 92, 206/219, 206/221, 222/246, 366/129, 366/130, 366/256, 366/257, 366/268, 366/269, 366/332, 366/337
• US Class Current: 366/130
• CPC Class Codes: A61M 2005/31506 formed as a single piece, e.g. moulded
• CPC Class Codes: A61M 2005/31598 having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31596 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: B01F 31/441 performing a rectilinear reciprocating movement
• CPC Class Codes: B01F 33/5011 portable during use, e.g. hand-held
• CPC Class Codes: B01F 33/50112 of the syringe or cartridge type
• CPC Class Codes: B01F 35/713 comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges containers or packages per se B65D
• CPC Class Codes: B01F 35/7137 Piercing, perforating or melting membranes or closures which seal the compartments
• CPC Class Codes: B01F 35/7162 A container being placed inside the other before contacting the contents
• CPC Class Codes: B01F 35/754251 reciprocating in the mixing receptacle

Abstract

The apparatus for production of mixtures from two components has a container for each and devices to combine the components in the mixing space and for extrusion of the mixture. The powdered component (4) is situated in the lower part of the inner space (21), which is sealed by a bottom (10). This carries a nozzle (2) with closure membrane (3). The inner space (21) is closed on the top by the lower wall (6) and the sliding seal (8). The liquid component (9) is situated in the inner space (18) of the inner hollow cylinder (5). This is closed on the top by the upper wall (11). The lower and upper wall (6) and (11) each have an opening with sealing lips (7) and (12) that are closed by parts of the mixing rod (15). A torus (20), a section with smaller diameter (19), a mixing disk (22), as well as a mandrel (24), are present on the lower part of the mixing rod (15).

Claims

1. A mixing syringe comprising:

a syringe barrel having a hollow interior and an outlet nozzle at a lower end;

a plunger having a hollow interior reciprocatably disposed in the hollow interior of the syringe barrel;

a mixing rod reciprocatably disposed in the hollow interior of the syringe barrel and having a mixing element at its lower end which is adapted to mix material in the hollow interior of the syringe barrel upon reciprocation of the mixing rod, wherein the mixing element has openings to enhance mixing;

said plunger and mixing rod having a first relative position wherein the hollow interiors of the syringe barrel and of the plunger are sealed from each other and a second relative position wherein the hollow interiors are in fluid communication.

2. A mixing syringe as in claim 1, further comprising a frangible seal over the nozzle and a mandrel coupled to the mixing rod or plunger for blocking the seal.

3. A mixing syringe as in claim 1, wherein the mixing element comprises a mixing disk.

4. A mixing syringe as in claim 1, wherein the mixing rod is coaxially disposed through a passage in a bottom well of the plunger.

5. A mixing syringe as in claim 4, wherein the mixing rod seals against the passage in the first relative position but not in the second relative position.

6. A mixing syringe as in claim 1, further comprising a sealing cylinder disposed in the hollow interior of the plunger.

7. A mixing syringe as in claim 6, wherein the mixing rod is disposed through coaxially aligned passages on the plunger and the sealing cylinder.

8. A mixing syringe as in claim 7, further comprising sliding seals on the mixing rod which are positioned to seal against the passages on the plunger and sealing cylinder when in the first relative position but do not seal when in the second relative position.

9. Apparatus for production of mixtures of two components with a container for one component and a container for the other component, and with devices for combining the two components in a mixing space, and devices for extrusion of the finished mixture, characterized by the fact that the powdered component 4 is situated in the lower part of the inner space 21 of the outer hollow cylinder 1, which is closed on its lower end with a bottom 10 that carries a nozzle 2 that is sealed relative to inner space 21 by means of a closure membrane 3, whereas the upper part of the inner space 21 is closed by the lower wall 6 of the inner hollow cylinder 5, in which a sliding seal 8 is present for the required sealing, and that the liquid component 9 is situated in the inner space 18 of the inner hollow cylinder 5, which is disposed to reciprocate in the outer hollow cylinder 1 and is closed on its lower end by the lower wall 6, whereas its upper end is closed by the upper wall 11, and that the lower wall 6, as well as the upper wall 11, each have an opening with the sealing lip 7 and 12 that are closed by those parts of the mixing rod 15 that have the larger diameter 17, and that on the lower part of the mixing rod 15 a torus 20, a section with smaller diameter 19, a mixing disk 22, as well as a mandrel 24 are present.

10. Apparatus according to claim 9, characterized by the fact that a plastic enclosure is present, in which the apparatus according to the invention is sealed airtight.

11. Apparatus according to any of claim 9 or 10, characterized by the fact that the outer hollow cylinder 1 has an annular flange 14, the inner hollow cylinder 5 has an annular flange 13 and the mixing rod 15 has a flange plate 16.

12. Apparatus according to any of claim 9, characterized by the fact that openings 23 are present on the mixing disk 22.

13. Apparatus according to any of claim 9, characterized by the fact that a mandrel 24 is present on the lower end of the mixing rod 15.

14. Apparatus according to any of claim 9, characterized by the fact that an inside thread 29 is present on the inside of the outer hollow cylinder 1 in the upper region, whereas an outside thread 28 is present on the outside of the inner hollow cylinder 5.

15. Apparatus according to any of claim 9, characterized by the fact that knurling 30 is present on the annular flanges 13 and 14.

16. Apparatus according to any of claim 9, characterized by the fact that an annular groove (37) that accommodates the sliding seal 8 is situated on the inner periphery of outer hollow cylinder 1.

17. Apparatus according to any of claim 9, characterized by the fact that an operating part 31 is present on the annular flange 14 of the outer hollow cylinder 1 that consists of a connection part 32, a spring element 33, an operating element 34, as well as a detent 35, and that toothing 36 is present on the outer periphery of the inner hollow cylinder 5.