Iontophoresis system

• US 7,018,345 B2
• Filed: 12/05/2003
• Issued: 03/28/2006
• Est. Priority Date: 12/06/2002
• Status: Active Grant

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Higo, Naruhito, Mori, Kenji
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US10/727,582
• Publication Number:
  US 20040116964A1
• Time in Patent Office: 844 Days
• Field of Search: 604 20- 21, 600/362, 600/573, 600/579, 600/368, 600/349, 607/149
• US Class Current: 600/573
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

The present invention provides an iontophoresis system for non-invasively taking a physiological substance out of the living body, the system being suitably used for the mucous membrane. The present iontophoresis system non-invasively takes a physiological substance out of a living body. The system includes a plurality of electrode structures and a power supply device connected to the electrode structures. At least one of the electrode structures has a physiological substance extraction pad applied to the mucous membrane. In the present system, the time to apply electric energy to the living body by the power supply device is set between 30 seconds and 20 minutes. The physiological substance extraction pad which is provided in the electrode structure is applicable to the mucous membrane of the mouth and can be used, for example, to monitor glucose in the living body or an amount of drug administered.

Claims

1. An iontophoresis system for non-invasively extracting a physiological substance out of a living body comprising:

a first electrode structure having a physiological extraction pad thereon, said first electrode structure affixed to a first fixing member,

a second electrode structure affixed to a second fixing member, said second fixing member hingedly engaged with said first fixing member at a hinge connection so as to form a cross shape,

a spring member in attachment to the first fixing member and the second fixing member, on one side of the hinge connection, so as to bias the first electrode structure and the second electrode structure together, and

a power supply device connected to the electrode structures.

2. The iontophoresis system according to claim 1, wherein one of the first electrode structures is provided for the mucous membrane of the mouth, and the second electrode structure is provided for the skin.

3. A method of analyzing a physiological substance using the iontophoresis system of claim 1 to non-invasively remove a physiological substance from a living body for analysis, comprising:

applying the physiological substance extraction pad to a mucous membrane,

applying electric energy of 10 volts or less to the living body via the pad for 30 seconds to 20 minutes by iontophoresis, and

quantifying or qualitatively measuring a physiological substance extracted in the pad.

4. The method of analyzing a physiological substance according to claim 3, wherein the physiological substance extraction pad is used to extract glucose.

5. The method of analyzing a physiological substance according to claim 3, wherein the physiological substance extraction pad is adapted to be applied to a mucous membrane of a mouth.

6. The iontophoresis system according to claim 1, wherein the electrode structure having the first electrode further comprises a device quantifying the physiological substance or a device qualitatively measuring the physiological substance.

7. The iontophoresis system according to claim 1, wherein the physiological substance is a drug administered for treatment.

8. The iontophoresis system of claim 1, further comprising a glucose sensor in connection with the first and/or second electrode.

9. The iontophoresis system of claim 8, wherein the glucose sensor in connection with the first and/or second electrode comprises:

a first sensor electrode,

a second sensor electrode, and

a detector conductively connecting the first sensor electrode and the second sensor electrode.

10. The iontophoresis system of claim 1, further comprising a general antigen and antibody sensor in connection with the first and/or second electrode.