Instrument
First Claim
1. A method for determining the concentration of glucose in blood, a blood fraction or a control, the blood, blood fraction or control including red blood cells or red blood cell fractions which affect the determination of the concentration of glucose, the method including performing a first measurement on the blood, blood fraction or control which first measurement varies with both the concentration of glucose and at least one of the presence and concentration of red blood cells or red blood cell fractions, which first measurement comprises a measurement of a time-varying function i1 (t) having the general form
i1(t)=M/sqrt(t)+Bwhere t is time from initiating the measurement, M is the slope of a graph of the function and B is a value the function approaches as t becomes very large, performing a second measurement on the blood, a blood fraction or control which second measurement has the form of a time-varying function i2(t), where t is time, t<
- some arbitrarily established time, i2(t) varying primarily only with the at least one of the presence and concentration of red blood cells or red blood cell fractions to develop an indication of the at least one of the presence and concentration of red blood cells or red blood cell fractions, and removing an amount representative of the indicated presence or concentration of red blood cells or red blood cell fractions from the concentration of glucose indicated by the first measurement to provide the concentration of glucose in the blood, blood fraction or control.
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Accused Products
Abstract
A method and apparatus for performing a first measurement on a biological fluid or control, which first measurement varies with both the concentration of a first component and at least one of the presence and concentration of a second component. The method and apparatus perform a second measurement on the biological fluid or control, which second measurement varies primarily only with the at least one of the presence and concentration of the second component to develop an indication of the at least one of the presence and concentration of the second component. The first and second measurements may be made sequentially or simultaneously. The method and apparatus then remove an amount representative of the indicated presence or concentration of the second component from the concentration of the first component indicated by the first measurement.
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Citations
63 Claims
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1. A method for determining the concentration of glucose in blood, a blood fraction or a control, the blood, blood fraction or control including red blood cells or red blood cell fractions which affect the determination of the concentration of glucose, the method including performing a first measurement on the blood, blood fraction or control which first measurement varies with both the concentration of glucose and at least one of the presence and concentration of red blood cells or red blood cell fractions, which first measurement comprises a measurement of a time-varying function i1 (t) having the general form
i1(t)=M/sqrt(t)+Bwhere t is time from initiating the measurement, M is the slope of a graph of the function and B is a value the function approaches as t becomes very large, performing a second measurement on the blood, a blood fraction or control which second measurement has the form of a time-varying function i2(t), where t is time, t< - some arbitrarily established time, i2(t) varying primarily only with the at least one of the presence and concentration of red blood cells or red blood cell fractions to develop an indication of the at least one of the presence and concentration of red blood cells or red blood cell fractions, and removing an amount representative of the indicated presence or concentration of red blood cells or red blood cell fractions from the concentration of glucose indicated by the first measurement to provide the concentration of glucose in the blood, blood fraction or control.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. Apparatus for determining the concentration of glucose in blood, a blood fraction or a control, the blood, blood fraction or control including red blood cells or red blood cell fractions which affect the determination of the concentration of glucose, the apparatus including a device that performs a first measurement on the blood, blood fraction or control which first measurement varies with both the concentration of glucose and at least one of the presence and concentration of red blood cells or red blood cell fractions, the device performing measurements of a time-varying function i1(t) having the general form
i1(t)=M/sqrt(t)+Bwhere t is time from initiating the measurement, M is the slope of a graph of the function and B is a value the function approaches as t becomes very large, the device further performing a second measurement of a time-varying function i2(t) of the blood, blood fraction or control, where t is time, t< - some arbitrarily established time, which second measurement varies primarily only with the at least one of the presence and concentration of red blood cells or red blood cell fractions to develop an indication of the at least one of the presence and concentration of red blood cells or red blood cell fractions, the device further removing an amount representative of the indicated presence or concentration of red blood cells or red blood cell fractions from the concentration of glucose indicated by the first measurement.
- View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for determining the concentration of glucose in blood, a blood fraction or a control, the blood, blood fraction or control including red blood cells or red blood cell fractions which affect the determination of the concentration of glucose, the method including performing a first measurement of a time-varying function i1(t) of the blood, blood fraction or control, i1(t) varying with both the concentration of glucose and at least one of the presence and concentration of red blood cells or red blood cell fractions, i1(t) having the general form
i1(t)=M/sqrt(t)+Bwhere t is time from initiating the measurement, M is the slope of a graph of the function and B is a value the function approaches as t becomes very large, performing a second measurement on the blood, blood fraction or control which second measurement also varies with the at least one of the presence and concentration of red blood cells or red blood cell fractions to develop an indication of the at least one of the presence and concentration of red blood cells or red blood cell fractions, and removing an amount representative of the indicated presence or concentration of red blood cells or red blood cell fractions from the concentration of glucose indicated by the first measurement to provide the concentration of glucose in the blood, blood fraction or control.
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44. Apparatus for determining the concentration of a glucose in blood, a blood fraction or a control, the blood, blood fraction or control including red blood cells or red blood cell fractions which affect the determination of the concentration of glucose, the apparatus including a device that performs a first measurement of a time-varying function i1(t) of the blood, blood fraction or control, i1(t) varying with both the concentration of glucose and at least one of the presence and concentration of red blood cells or red blood cell fractions, i1(t) having the general form
i1(t)=M/sqrt(t)+Bwhere t is time from initiating the measurement, M is the slope of a graph of the function and B is a value the function approaches as t becomes very large, the device further performing a second measurement on the blood, a blood fraction or control which second measurement varies primarily only with the at least one of the presence and concentration of red blood cells or red blood cell fractions to develop an indication of the at least one of the presence and concentration of red blood cells or red blood cell fractions, and the device further removing an amount representative of the indicated presence or concentration of red blood cells or red blood cell fractions from the concentration of glucose indicated by the first measurement.
Specification