Hemostatic wound dressings and methods of making same
First Claim
1. A process for the manufacture of a hemostatic wound dressing, comprising:
- providing a polymer solution comprising a water-soluble or water-swellable biocompatible polymer dissolved in a solvent for said polymer, providing a fabric substrate comprising a first surface and a second surface opposing said first surface, said fabric having properties effective for use as a hemostat and comprising fibers prepared from a biocompatible polymer, contacting said fabric substrate with said polymer solution under conditions effective to distribute said polymer solution substantially homogenously on said first and second surfaces and through said fabric substrate, transferring said fabric substrate having said polymer solution substantially homogenously distributed there through to a lyophilization unit under conditions effective to maintain said homogeneous distribution on and throughout said substrate; and
lyophilizing said fabric having said polymer solution distributed there through;
thereby providing a porous, polymeric matrix substantially homogeneously distributed on said first and second surfaces and through said fabric substrate, said matrix comprising said lyophilized water-soluble or water-swellable polymer.
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Abstract
The present invention is directed to methods of making wound dressings that include the steps of contacting a fabric substrate having properties effective for use as a hemostat and containing fibers prepared from a biocompatible polymer, with a solution of a water-soluble or water-swellable biocompatible polymer under conditions effective to distribute the polymer solution substantially homogenously on and through the fabric substrate, transferring the fabric substrate to a lyophilization unit under conditions effective to maintain the homogeneous distribution on and throughout the substrate, and lyophilizing the fabric having the polymer solution distributed on and there through.
109 Citations
23 Claims
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1. A process for the manufacture of a hemostatic wound dressing, comprising:
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providing a polymer solution comprising a water-soluble or water-swellable biocompatible polymer dissolved in a solvent for said polymer, providing a fabric substrate comprising a first surface and a second surface opposing said first surface, said fabric having properties effective for use as a hemostat and comprising fibers prepared from a biocompatible polymer, contacting said fabric substrate with said polymer solution under conditions effective to distribute said polymer solution substantially homogenously on said first and second surfaces and through said fabric substrate, transferring said fabric substrate having said polymer solution substantially homogenously distributed there through to a lyophilization unit under conditions effective to maintain said homogeneous distribution on and throughout said substrate; and
lyophilizing said fabric having said polymer solution distributed there through;
thereby providing a porous, polymeric matrix substantially homogeneously distributed on said first and second surfaces and through said fabric substrate, said matrix comprising said lyophilized water-soluble or water-swellable polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification