Chemical detection sensor system

• US 7,022,288 B1
• Filed: 11/13/2002
• Issued: 04/04/2006
• Est. Priority Date: 11/13/2002
• Status: Active Grant

• Current Assignee: The Government Of The United States As Represented By The Secretary Of The Navy
• Original Assignee: the united states of america as represented by the secretary of the navy
• Inventors: Boss, Pamela
• Primary Examiner(s): Soderquist, Arlen
• Application Number:
  US10/294,655
• Time in Patent Office: 1,238 Days
• Field of Search: 356/301, 422/68.1, 422 8201- 8202, 422 8205- 8206, 436/86, 436 91- 93, 436/96, 436/98, 436/104, 436/107, 436/110, 436/120, 436/124, 436128-135, 436139-142, 436/147, 436/164, 436149-151, 436/167, 436/181
• US Class Current: 422/82.05
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: G01N 21/658 enhancement Raman, e.g. surface plasmons
• CPC Class Codes: Y10T 436/25875 Gaseous sample or with change of physical state

Abstract

A chemical detection sensor system comprises a support structure; multiple SERS chemical detection sensors supported by the support structure; multiple chemical reaction sensors, wherein each of the chemical reaction sensors is disposed for undergoing a state change in response to an occurrence of a chemical reaction at one of the SERS chemical detection sensors; a processor supported by the support structure for recording data representing occurrence of a chemical reaction at any of the chemical detection sensors in response to sensing the state change; and a power source for energizing the processor.

Claims

1. A chemical detection sensor system, comprising:

a support structure;

SERS chemical detection sensors supported by said support structure, wherein each SERS chemical detection sensor is disposed to undergo a chemical reaction and a state change in the presence of an analyte;

chemical reaction sensors, wherein each one of said chemical reaction sensors is operably coupled to one of said SERS chemical detection sensors and disposed to detect said state change;

a processor operably coupled to said chemical reaction sensors and disposed to record said state change; and

a power source disposed to energize said processor.

2. The chemical detection sensor system of claim 1 wherein each of said SERS chemical detection sensors comprises:

a glass substrate having a roughened surface;

an adhesion layer formed on said roughened surface;

metal islands formed on said adhesion layer to define a metal patterned structure; and

a self-assembled monolayer formed over said metal islands.

3. The chemical detection sensor system of claim 2 wherein metal islands consist essentially of a metal selected from the group consisting of copper, silver, and gold.

4. The chemical detection sensor system of claim 2 wherein said metal islands are formed by vapor depositing said metal on said adhesion layer.

5. The chemical detection sensor system of claim 2 wherein said self-assembled monolayer is a thiol selected from the group consisting of 1-propanethiol, cysteamine hydrochloride, 4-(2-pyridylazo) resorcinol modified with a disulfide, and thiol derivatized dibenzo 18-crown-6.

6. The chemical detection sensor system of claim 2 wherein said roughened surface has an average surface roughness that does not exceed about 2,500 Å

.

7. The chemical detection sensor system of claim 2 wherein said roughened surface has an average peak-to-peak periodicity that does not exceed about 12.5 microns.

8. The chemical detection sensor system of claim 2 wherein said roughened surface has an average surface roughness that does not exceed about 2,500 Å

and an average peak-to-peak periodicity that does not exceed about 12.5 microns.

9. The chemical detection sensor system of claim 2 further including a hydrogel layer formed over said self-assembled monolayer.

10. The chemical detection sensor system of claim 9 wherein said chemical reaction sensor is selected from the group consisting of a pH sensor, surface acoustic wave device, thermocouple, and electrical conductivity sensor.

11. The chemical detection sensor system of claim 1 further comprising:

a clock disposed to generate a clock signal representing a time value; and

wherein said processor is disposed to record said time value when said processor records said data.

12. The chemical detection sensor system of claim 1 further comprising:

a global positioning system disposed to generate a global positioning signal representing a global position value; and

wherein said processor is disposed to record said global position value when said processor records said data.

13. A chemical detection sensor system sensor, comprising:

a support structure;

SERS chemical detection sensors supported by said support structure, wherein each SERS chemical detection sensor is disposed for undergoing a chemical reaction and a state change in the presence of an analyte;

chemical reaction sensors, wherein each one of said chemical reaction sensors is operably coupled to one of said SERS chemical detection sensors and disposed to detect said state change;

a clock disposed to generate a clock signal representing a time value;

a global positioning system disposed to generate a global positioning signal representing a global position value;

a processor operably coupled to said chemical reaction sensors and disposed to record said time value, said global position value and data representing said state change; and

a power source disposed to energize said processor.

14. The chemical detection sensor system of claim 13 wherein each of said SERS chemical detection sensors comprises:

a glass substrate having a roughened surface;

an adhesion layer formed on said roughened surface;

metal islands formed on said adhesion layer to define a metal patterned structure; and

a self-assembled monolayer formed over said metal islands.

15. The chemical detection sensor system of claim 14 wherein metal islands consist essentially of a metal selected from the group consisting of copper, silver, and gold.

16. The chemical detection sensor system of claim 14 wherein said metal islands are formed by vapor depositing said metal on said adhesion layer.

17. The chemical detection sensor system of claim 14 wherein said self-assembled monolayer is a thiol selected from the group consisting of 1-propanethiol, cysteamine hydrochloride, 4-(2-pyridylazo) resorcinol modified with a disulfide, and thiol derivatized dibenzo 18-crown-6.

18. The chemical detection sensor system of claim 14 wherein said roughened surface has an average surface roughness that does not exceed about 2,500 Å

.

19. The chemical detection sensor system of claim 14 wherein said roughened surface has an average peak-to-peak periodicity that does not exceed about 12.5 microns.

20. The chemical detection sensor system of claim 14 wherein said roughened surface has an average surface roughness that does not exceed about 2,500 Å

and an average peak-to-peak periodicity that does not exceed about 12.5 microns.

21. The chemical detection sensor system of claim 14 further including a hydrogel layer formed over said self-assembled monolayer.

22. The chemical detection sensor system of claim 21 wherein said chemical reaction sensor is selected from the group consisting of a pH sensor, surface acoustic wave device, thermocouple, and electrical conductivity sensor.

23. A chemical detection sensor system, comprising:

a support structure;

SERS chemical detection sensors supported by said support structure, wherein each of said SERS chemical detection sensors is disposed to undergo a chemical reaction and a state change in the presence of an analyte, and comprises;

a transparent substrate having a roughened surface;

an adhesion layer formed on said roughened surface;

metal islands formed on said adhesion layer to define a metal patterned structure; and

a self-assembled monolayer formed over said metal islands;

chemical reaction sensors, each one comprising a light emitting diode and a photodetector affixed to said transparent substrate opposite said self-assembled monolayer, wherein each one of said chemical reaction sensors is operably coupled to one of said SERS chemical detection sensors and disposed to detect said state change;

a processor operably coupled to said chemical reaction sensors and disposed to record data representing said state change; and

a power source disposed to energize said processor and said chemical reaction sensors.