Hydrogel particle formulation
First Claim
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1. A method for making a powdered pharmaceutical composition, said method comprising:
- (a) providing a mixture of pre-formed hydrogel particles;
(b) contacting the hydrogel particles with an aqueous composition containing at least one pharmacologically active agent for a period sufficient to allow the agent to associate with the hydrogel particles and be incorporated therewith;
(c) separating the hydrogel particles from the aqueous composition in at least a partial drying step to obtain primary loaded hydrogel particles having the active agent incorporated therewith;
(d) contacting the primary loaded hydrogel particles with an aqueous composition containing said pharmacologically active agent for a period sufficient to allow further agent to associate with the hydrogel particles and be incorporated therewith;
(e) separating the hydrogel particles formed in step (d) from the aqueous composition in at least a partial drying step to obtain secondary loaded hydrogel particles having the active agent incorporated therewith; and
(f) drying the secondary loaded hydrogel particles to obtain a powdered pharmaceutical composition.
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Abstract
New compositions formed from the combination of an active substance with a hydrogel carrier moiety are provided. The compositions are suitable for use in high-velocity transdermal particle injection techniques. Methods of providing the new compositions are also provided. In addition, methods for administering pharmacologically active agent to a subject are provided. These methods are useful for delivering drugs, biopharmaceuticals, vaccines and diagnostics agents.
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Citations
15 Claims
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1. A method for making a powdered pharmaceutical composition, said method comprising:
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(a) providing a mixture of pre-formed hydrogel particles;
(b) contacting the hydrogel particles with an aqueous composition containing at least one pharmacologically active agent for a period sufficient to allow the agent to associate with the hydrogel particles and be incorporated therewith;
(c) separating the hydrogel particles from the aqueous composition in at least a partial drying step to obtain primary loaded hydrogel particles having the active agent incorporated therewith;
(d) contacting the primary loaded hydrogel particles with an aqueous composition containing said pharmacologically active agent for a period sufficient to allow further agent to associate with the hydrogel particles and be incorporated therewith;
(e) separating the hydrogel particles formed in step (d) from the aqueous composition in at least a partial drying step to obtain secondary loaded hydrogel particles having the active agent incorporated therewith; and
(f) drying the secondary loaded hydrogel particles to obtain a powdered pharmaceutical composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for making a powdered pharmaceutical composition, said method comprising:
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(a) providing a mixture of pre-formed hydrogel particles;
(b) contacting the hydrogel particles with an aqueous composition containing at least one pharmacologically active agent for a period sufficient to allow the agent to associate with the hydrogel particles and be incorporated therewith;
(c) separating the hydrogel particles from the aqueous composition in at least a partial drying step to obtain primary loaded hydrogel particles having the active agent incorporated therewith;
(d) contacting the primary loaded hydrogel particles formed in step (c) at least one further time with an aqueous composition containing said pharmacologically active agent for a period sufficient to allow further agent to associate with the bydrogel particles and be incorporated therewith arid separating the hydrogel particles formed from the aqueous composition at least one further time in at least a partial diying step to obtain loaded hydrogel particles having the active agent incorporated therewith; and
(e) drying the loaded hydrogel particles to obtain a powdered pharmaceutical composition. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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Specification