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Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system

  • US 7,022,321 B2
  • Filed: 04/11/2002
  • Issued: 04/04/2006
  • Est. Priority Date: 04/10/1997
  • Status: Expired due to Fees
First Claim
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1. A method of treating Parkinson'"'"'s disease, comprising:

  • transfecting harvested bone marrow cells with a retroviral vector comprising a gene for glial cell line-derived neurotrophic factor (GDNF);

    administering the transfected cells intravenously to a subject having Parkinson'"'"'s disease; and

    allowing the transfected cells to migrate to the brain of the subject and express the GDNF gene, thereby treating the Parkinson'"'"'s disease.

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