Method and apparatus for monitoring the autonomic nervous system

• US 7,024,234 B2
• Filed: 09/19/2003
• Issued: 04/04/2006
• Est. Priority Date: 09/20/2002
• Status: Active Grant

• Current Assignee: Pro-Tech Services, Inc. (Respironics Incorporated)
• Original Assignee: Pro-Tech Services, Inc. (Respironics Incorporated)
• Inventors: Riggins, Michael, Harrell, David B., Margulies, Lyle Aaron
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): Natarajan, Vivek
• Application Number:
  US10/666,121
• Publication Number:
  US 20040059236A1
• Time in Patent Office: 928 Days
• Field of Search: 600/324, 600/323, 600/310, 600/500, 600/501
• US Class Current: 600/324
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

An apparatus and method for detection and monitoring of autonomic nervous system (ANS) activity in humans, primarily in the field of sleep research. The present invention discloses a portable, simple, and cost-effective electronic device containing hardware and software that permits real-time monitoring of a pulsatile blood volume waveform obtained through use of a photoplethysmographic (optical volume detecting) probe, thereby allowing signal conditioning, waveform slope analysis, display, recording, and output of pulse transitional slope data representative of activity in the ANS.

Claims

1. An apparatus for monitoring human autonomic nervous system activity using pulsatile blood volume waveform signals, said apparatus comprising:

a photoplethysmographic probe having a light emitting element and an opposing light detecting element, and having an output signal indicating changes in blood volume on at least one alpha andrenergic receptor site of a human body;

a processor element, responsive to said output signal indicating changes in blood volume, said processor element defining a time interval for calculation of slope of blood volume waveform continuously and in real time and reducing said waveform signals to a slope value within said time interval;

said processor element containing an algorithm for normalization of the slope value;

said processor element containing an artifact rejection algorithm for eliminating from further processing slope values less than one; and

amplifier and filter circuitry for rendering output signals representative of said slope values.

2. The apparatus of claim 1, wherein the photoplethysmographic probe is adapted for application on a finger.

3. The apparatus of claim 1, wherein the photoplethysmographic probe is adapted for indirect application to the alpha andrenergic receptor site, whereby no direct contact with a body part is required.

4. The apparatus of claim 3, further comprising a display for indicating information representative of pulsatile blood volume waveform signals.

5. The apparatus of claim 3, further comprising a display for indicating information representative of slope values.

6. The apparatus of claim 3, further comprising a display for indicating information representative of a slope ratio.

7. The apparatus of claim 1, further comprising at display for visual indication of output signals.

8. The apparatus of claim 1, further comprising an electronic storage medium for data storage capability.

9. The apparatus of claim 1, further comprising at least one data part for downloading output signals.

10. A method for identification of human autonomic nervous system activity, the method comprising the steps of:

disposing a photoplethysmographic probe proximate to a single alpha andrenergic receptor site of a human body part;

obtaining an electrical signal from said probe representative of pulsatile blood volume within said body part;

deriving a pulsatile blood volume waveform as a function of amplitude and time;

defining a time interval for calculation of a slope of the pulsatile blood volume waveform;

applying an algorithm that continuously provides real-time calculation of the slope along said waveform within said time interval;

dividing peak amplitude values by a time constant and eliminating slope values less than 1, whereby artifact elimination is achieved;

normalizing slope values; and

providing information representative of slope values, whereby autonomie nervous system activity is monitored.

11. The method of claim 10 further comprising the step of applying signal filtration means, wherein undesirable low and high frequency signal components are eliminated.

12. The method of claim 10 further comprising the step of monitoring the pulsatile blood volume amplitude.

13. The method of claim 10 further comprising the step of amplifying and filtering slope values, whereby improved sensitivity and accuracy is achieved.

14. The method of claim 10 further comprising the step of providing an output display of visual information representative of slope values.

15. The method of claim 10 further comprising the step of providing data output representative of input data and slope values.

16. The method of claim 10 further comprising the step of providing a means for storing data representative of input data and slope values.