Generation of therapeutic microfoam
First Claim
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1. A method for producing a microfoam suitable for use in sclerotherapy of blood vessels characterized in that it comprises passing a mixture of a physiologically acceptable blood dispersible gas and an aqueous sclerosant liquid through one or more passages having at least one cross-sectional dimension of from 0.1 to 30 μ
- m, the ratio of gas to liquid being controlled such that a microfoam is produced having a density of between 0.07 g/mL to 0.19 g/mL and has a half-life of at least 2 minutes.
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Abstract
Improved therapeutic sclerosing microfoams are provided that have advantage in producing a consistent profile injectable foam with minimal input by the physician yet using high volume percentages of blood dispersible gases, thus avoiding use of potentially hazardous amounts of nitrogen.
59 Citations
27 Claims
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1. A method for producing a microfoam suitable for use in sclerotherapy of blood vessels characterized in that it comprises passing a mixture of a physiologically acceptable blood dispersible gas and an aqueous sclerosant liquid through one or more passages having at least one cross-sectional dimension of from 0.1 to 30 μ
- m, the ratio of gas to liquid being controlled such that a microfoam is produced having a density of between 0.07 g/mL to 0.19 g/mL and has a half-life of at least 2 minutes.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A device for producing a microfoam suitable for use in sclerotherapy of blood vessels comprising a housing in which is sutuated a pressurisable chamber with one or more outlet orifices, a pathway by which contents of the chamber may be passed to an exterior of the housing through the one or more outlet orifices, and a mechanism by which the chamber can be pressurized such that its contents therein pass to the exterior along the pathway and through the one or more outlet orifices, said pathway to the exterior of the housing or the chamber including one or more elements defining one or more passages of cross sectional dimension 0.1 μ
- m to 30 μ
m through which contents of the chamber are passed upon actuation of the mechanism, wherein the chamber contains an aqueous sclerosant liquid and/or a physiologically acceptable blood dispersible gas. - View Dependent Claims (20, 24, 25, 26, 27)
- m to 30 μ
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21. A device for producing a microfoam suitable for use in sclerotherapy of blood vessels comprising a housing in which is situated a pressurisable chamber with one or more outlet orifices, a pathway by which contents of the chamber may be passed to an exterior of the housing through the one or more outlet orifices, and a mechanism by which the chamber can be pressurized such that its contents therein pass to the exterior along the pathway and through the one or more outlet orifices, said pathway to the exterior of the housing or the chamber including one or more elements defining one or more passages of cross sectional dimension 0.1 μ
- m to 30 μ
m through which contents of the chamber are passed upon actuation of the mechanism, wherein the elements defining the passages in the pathway or chamber are mounted on a moveable support, said support being moveable by manipulation from outside of the chamber. - View Dependent Claims (22, 23)
- m to 30 μ
Specification