Apparatus for detecting sleep apnea using electrocardiogram signals
First Claim
1. An apparatus useful in diagnosing sleep apnea in a human patient, the apparatus comprising:
- means for measuring a cardiac electrical potential of the patient and for generating an electrocardiogram signal over a time period;
means for analyzing the electrocardiogram signal and for deriving a respiratory signal therefrom;
means for partitioning the electrocardiogram signal into a set of time periods shorter than the time period of the electrocardiogram signal;
means for classifying each time period in the set of time periods as either apneic or normal; and
means for combining classification results from a plurality of the time periods and for providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results.
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Accused Products
Abstract
There is provided a method of determining a diagnostic measure of sleep apnea including the following steps: acquiring an electrocardiogram signal, calculating a set of RR intervals and electrocardiogram-derived respiratory signal from said electrocardiogram, and hence calculating a set of spectral and time-domain measurements over time periods including power spectral density, mean, and standard deviation. These measurements are processed by a classifier model which has been trained on a pre-existing data base of electrocardiogram signals to provide a probability of a specific time period containing apneic episodes or otherwise. These probabilities can be combined to form an overall diagnostic measure. The system also provides a system and apparatus for providing a diagnostic measure of sleep apnea.
146 Citations
64 Claims
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1. An apparatus useful in diagnosing sleep apnea in a human patient, the apparatus comprising:
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means for measuring a cardiac electrical potential of the patient and for generating an electrocardiogram signal over a time period; means for analyzing the electrocardiogram signal and for deriving a respiratory signal therefrom; means for partitioning the electrocardiogram signal into a set of time periods shorter than the time period of the electrocardiogram signal; means for classifying each time period in the set of time periods as either apneic or normal; and means for combining classification results from a plurality of the time periods and for providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. An apparatus useful in diagnosing sleep apnea in a human patient, the apparatus comprising:
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means for measuring a cardiac electrical potential of the patient and for generating an electrocardiogram signal over a time period; means for analyzing the electrocardiogram signal comprising both time domain and frequency domain processing; means for partitioning the electrocardiogram signal into a set of time periods shorter than the time period of the electrocardiogram signal; means for classifying each time period in the set of time periods as either apneic or normal; and means for combining classification results from a plurality of the time periods and for providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results. - View Dependent Claims (26)
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27. An apparatus useful in diagnosing sleep apnea in a human patient, the apparatus comprising:
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means for measuring a cardiac electrical potential of the patient and for generating an electrocardiogram signal over a time period; means for analyzing the electrocardiogram signal and for deriving a respiratory signal therefrom; means for partitioning the electrocardiogram signal into a set of time periods shorter than the time period of the electrocardiogram signal; means for classifying each time period in the set of time periods as either apneic or normal; and means for combining classification results from a plurality of the time periods and for providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results, wherein the means for analyzing the electrocardiogram signal comprises means for calculating a power spectral density of the electrocardiogram-derived respiratory signal. - View Dependent Claims (28)
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29. An apparatus useful in diagnosing sleep apnea in a human patient, the apparatus comprising:
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means for measuring a cardiac electrical potential of the patient and for generating an electrocardiogram signal over a time period; means for analyzing the electrocardiogram signal and for deriving a respiratory signal therefrom; means for partitioning the electrocardiogram signal into a set of time periods shorter than the time period of the electrocardiogram signal; means for classifying each time period in the set of time periods as either apneic or normal; and means for combining classification results from a plurality of the time periods and for providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results; means for determining a corrected set of RR intervals for each time period in the set of time periods, wherein the means for classifying each time period in the set of time periods uses the corrected set of RR intervals and the derived respiratory signal, wherein a diagnostic measure of sleep apnea for the patient is provided using a combined classification result from a plurality of the time periods. - View Dependent Claims (30)
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31. An apparatus useful in diagnosing sleep apnea in a human patient, the apparatus comprising:
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means for measuring a cardiac electrical potential of the patient and for generating an electrocardiogram signal over a time period; means for analyzing the electrocardiogram signal and for partitioning the time period into plural time intervals each shorter than the time period of the electrocardiogram signal; means for determining a power spectral density during each of the plural time intervals; means for classifying each of the plural time intervals as either apneic or normal; and means for combining classification results from each of the plural time intervals and for providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results, wherein the means for classifying each of the plural time intervals at least uses a measurement of a power spectral density of an associated one of the plural RR intervals. - View Dependent Claims (32)
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33. A method for diagnosing sleep apnea in a human patient, the comprising:
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measuring a cardiac electrical potential of the patient and for generating an electrocardiogram signal over a time period; analyzing the electrocardiogram signal and for deriving a respiratory signal therefrom; partitioning the electrocardiogram signal into a set of time periods shorter than the time period of the electrocardiogram signal; classifying each time period in the set of time periods as either apneic or normal; and combining classification results from a plurality of the time periods and for providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. A method useful in diagnosing sleep apnea in a human patient, the method comprising:
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measuring a cardiac electrical potential of the patient and generating an electrocardiogram signal over a time period; analyzing the electrocardiogram signal using both time domain and frequency domain processing; partitioning the electrocardiogram signal into a set of time periods shorter than the time period of the electrocardiogram signal; classifying each time period in the set of time periods as either apneic or normal; and combining classification results from a plurality of the time periods and providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results. - View Dependent Claims (58)
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59. A method useful in diagnosing sleep apnea in a human patient, the method comprising:
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measuring a cardiac electrical potential of the patient and generating an electrocardiogram signal over a time period; analyzing the electrocardiogram signal and deriving a respiratory signal therefrom; partitioning the electrocardiogram signal into a set of time periods shorter than the time period of the electrocardiogram signal; classifying each time period in the set of time periods as either apneic or normal; and combining classification results from a plurality of the time periods and providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results, wherein said analyzing the electrocardiogram signal comprises calculating a power spectral density of the electrocardiogram-derived respiratory signal. - View Dependent Claims (60)
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61. A method useful in diagnosing sleep apnea in a human patient, the method comprising:
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measuring a cardiac electrical potential of the patient and generating an electrocardiogram signal over a time period; analyzing the electrocardiogram signal and deriving a respiratory signal therefrom; partitioning the eelectrocardiogram signal into a set of time periods shorter than the time period of the electrocardiogram signal; classifying each time period in the set of time periods as either apneic or normal; and combining classification results from a plurality of the time periods and providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results; determining a corrected set of RR intervals for each time period in the set of time periods, wherein said classifying each time period in the set of time periods uses the corrected set of RR intervals and the derived respiratory signal, wherein a diagnostic measure of sleep apnea for the patient is provided using a combined classification result from a plurality of the time periods. - View Dependent Claims (62)
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63. A method useful in diagnosing sleep apnea in a human patient, the method comprising:
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measuring a cardiac electrical potential of the patient and generating an electrocardiogram signal over a time period; analyzing the electrocardiogram signal and partitioning the time period into plural rime intervals each shorter than the time period of the electrocardiogram signal; determining a power spectral density during each of the plural time intervals; classifying each of the plural time intervals as either apneic or normal; and combining classification results from each of the plural time intervals and providing a diagnostic measure of sleep apnea for the human patient based on the combined classification results, wherein said classifying each of the plural time intervals at least uses a measurement of a power spectral density of an associated one of the plural RR intervals. - View Dependent Claims (64)
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Specification