Please download the dossier by clicking on the dossier button x
×

Antibodies against human IL-12

  • US 7,026,456 B1
  • Filed: 08/30/2000
  • Issued: 04/11/2006
  • Est. Priority Date: 01/23/1998
  • Status: Expired due to Term
First Claim
Patent Images

1. A monoclonal antibody to human IL-12 which consists of a p35 subunit and a p40 subunit forming a p75 heterodimer, wherein said monoclonal antibody(a) immunologically reacts with an epitope presented by the p75 heterodimer of human IL-12, but is not immunologically reactive with any epitope presented by said p40 subunit;

  • and(b) neutralizes at least about 90% of the bioactivity of human IL-12, wherein the antibody neutralizes at least about 90% bioactivity of human IL-12 by inhibiting IL-12 stimulated PHA-activated human lymphoblast proliferation wherein the concentration of said antibody is 0.5μ

    g/ml and the concentration of said human IL-12 is 0.25 ng/ml.

View all claims
  • 0 Assignments
Timeline View
Assignment View
    ×
    ×