Implantable cardiac device having a system for detecting T wave alternan patterns and method

• US 7,027,867 B2
• Filed: 06/28/2002
• Issued: 04/11/2006
• Est. Priority Date: 06/28/2002
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Bradley, Kerry, Park, Euljoon
• Primary Examiner(s): Evanisko, George R.
• Assistant Examiner(s): Aguel, Fernando
• Application Number:
  US10/186,069
• Publication Number:
  US 20040002743A1
• Time in Patent Office: 1,383 Days
• Field of Search: 607/25, 607/26, 600/508, 600/509, 600/517
• US Class Current: 607/25
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

A system and method for use in an implantable cardiac device that delivers electrical therapy to a patient'"'"'s heart determines if a T wave alternan pattern of the patient'"'"'s heart exists. The system includes a sensing circuit that generates an electrical signal representing electrical activity of the patient'"'"'s heart. A morphology detector measures a magnitude of a T wave characteristic of each T wave in the electrical signal of a predetermined number of cardiac cycles of the heart. A discriminator then determines, responsive to the measured T wave characteristic magnitudes, if a T wave alternan pattern exists. A T wave alternan pattern may be determined to exist if the number of measured T wave characteristic magnitudes greater than and less than a T wave characteristic magnitude baseline are substantially equal and each greater than a given number.

Claims

1. In an implantable cardiac device, a system for detecting a T wave alternan pattern of a patient'"'"'s heart, comprising:

a sensing circuit that generates an electrical signal representing electrical activity of the patient'"'"'s heart;

morphology detector that receives the electrical signal from the sensing circuit and that measures a metric of a characteristic for each T wave in the electrical signal; and

a discriminator that receives the measured T wave characteristic metrics from the morphology detector and that determines, responsive to the measured T wave characteristic metrics for a plurality of T waves, if a T wave alternan pattern is present;

wherein the discriminator determines if a number of measured T wave characteristic magnitudes greater than and less than a T wave characteristic magnitude baseline are substantially equal and each greater than a given number.

3. The system of claim 1 wherein the T wave characteristic baseline is a mean of the measured T wave characteristic magnitudes and wherein the system includes a processor that determines the mean.

4. The system of claim 1 wherein the given number is one-fourth of the predetermined number.

5. The system of claim 1 further comprising a timer that activates the sensing circuit at spaced apart times.

6. The system of claim 1 further comprising an activity detector that detects when the patient is at rest and wherein the sensing circuit is activated by the activity detector when the patent is at rest.

7. The system of claim 1 wherein the T wave characteristic is T wave amplitude and wherein the morphology detector measures T wave amplitude magnitude of each T wave of the predetermined number of cardiac cycles.

8. The system of claim 1 wherein the implantable cardiac device includes a pulse generator that provides pacing pulses to the patient'"'"'s heart during paced cardiac cycles and wherein the morphology detector measures the magnitude of the T wave characteristic of only T waves occurring during paced cardiac cycles.

9. The system of claim 1 wherein the morphology detector measures the magnitude of the T wave characteristic of only intrinsic T waves.

10. The system of claim 1 wherein the predetermined number of cardiac cycles are consecutive cardiac cycles.

11. The system of claim 1 wherein the T wave characteristic is a T wave slope and wherein the morphology detector measures a T wave slope magnitude of each T wave of the predetermined number of cardiac cycles.

12. The system of claim 1 wherein the T wave characteristic is T wave area and wherein the morphology detector measures T wave area magnitude of each T wave of the predetermined number of cardiac cycles.

13. The system of claim 1 wherein the implantable cardiac device includes a lead system coupled to the sensing circuit, the lead system having a plurality of T wave sensing electrode configurations, and wherein the system includes a selecting circuit that selects an electrode configuration from the plurality of T wave sensing electrode configurations that maximizes the measured T wave characteristic.

14. The system of claim 1 further comprising a telemetry circuit that transmits to an external receiver the presence of a detected T wave alternan pattern.

15. The system of claim 1 further comprising a patient alert that provides an indication, perceptible by the patient, of a detected T wave alternan pattern.

16. The system of claim 1 further comprising a memory for storing at least one of heart rate, time of T wave alternan pattern detection, and patient activity level for the T wave alternan pattern detection.

17. The system of claim 1 further comprising a memory for maintaining a histogram of the T wave characteristic magnitudes.

2. The system of claim 2 wherein the T wave characteristic baseline is an average of the measured T wave characteristic magnitudes and wherein the system includes a processor that averages the measured T wave characteristic magnitudes.

18. In an implantable cardiac device that delivers electrical therapy to a patient'"'"'s heart, a system for detecting a T wave alternan pattern of the patients heart, comprising:

sensing means for generating an electrical signal representing electrical activity of the patients heart;

measuring means for measuring a magnitude of a T wave characteristic for each T wave in the electrical signal; and

detecting means, responsive to the measured T wave characteristic magnitudes for a plurality of T waves, for detecting a T wave alternan pattern;

wherein the detecting means includes means for determining if a number of measured T wave characteristic magnitudes greater than and less than a T wave characteristic magnitude baseline are substantially equal and each greater than a given number.

19. The system of claim 18 wherein the T wave characteristic baseline is an average of the measured T wave characteristic magnitudes and wherein the system includes processing means for averaging the measured T wave characteristic magnitudes.

20. The system of claim 18 wherein the T wave characteristic baseline is a mean of the measured T wave characteristic magnitudes and wherein the system includes processing means for calculating the mean.

21. The system of claim 18 wherein the given number is one-fourth of the predetermined number.

22. The system of claim 18 further comprising timing means for activating the sensing circuit at spaced apart times.

23. The system of claim 18 further comprising activity detecting means for detecting when the patient is at rest and wherein the sensing means generates the electrical signal when the patient is at rest.

24. The system of claim 18 wherein the T wave characteristic is T wave amplitude and wherein the measuring means includes means for measuring T wave amplitude magnitude of each T wave of the predetermined number of cardiac cycles.

25. The system of claim 18 wherein the implantable cardiac device includes pacing means for providing pacing pulses to the patient'"'"'s heart during paced cardiac cycles and wherein the measuring means measures the magnitude of the T wave characteristic of only T waves occurring during paced cardiac cycles.

26. The system of claim 18 wherein the measuring means measures the magnitude of the T wave characteristic of only intrinsic T waves.

27. The system of claim 18 wherein the predetermined number of cardiac cycles are consecutive cardiac cycles.

28. The system of claim 18 wherein the T wave characteristic is a T wave slope and wherein measuring means includes means for measuring a T wave slope magnitude of each T wave of the predetermined number of cardiac cycles.

29. The system of claim 18 wherein the T wave characteristic is T wave area and wherein the measuring means includes means for measuring T wave area magnitude of each T wave of the predetermined number of cardiac cycles.

30. The system of claim 18 wherein the implantable cardiac device includes a lead system coupled to the sensing means, the lead system having a plurality of T wave sensing electrode configurations, and wherein the system includes selecting means for selecting an electrode configuration from the plurality of T wave sensing electrode configurations that maximizes the measured T wave characteristic.

31. The system of claim 18 further comprising telemetry means for transmitting to an external receiver the presence of a detected T wave alternan pattern.

32. The system of claim 18 further comprising patient alert means for providing an indication, perceptible by the patient, of a detected T wave alternan pattern.

33. The system of claim 18 further comprising memory means for storing at least one of heart rate, time of T wave alternan pattern detection, and patient activity level for the T wave alternan pattern detection.

34. The system of claim 18 further comprising memory means for storing T wave characteristic histogram data.

35. In an implantable cardiac device, a method of detecting a T wave alternan pattern in a patient'"'"'s heart, the method comprising:

sensing electrical activity of the patient'"'"'s heart;

generating an electrical signal representing electrical activity of the patient'"'"'s heart;

computing a metric of a T wave characteristic for each T wave in the electrical signal; and

processing the measured T wave characteristic metrics for a plurality of T waves to determine whether a T wave alternan pattern exists;

wherein the detecting step includes the step of determining if a number of measured T wave characteristic magnitudes greater than and less than a T wave characteristic magnitude baseline are substantially equal and each greater than a given number.

36. The method of claim 35 wherein the T wave characteristic baseline is an average of the measured T wave characteristic magnitudes and wherein the method includes the further step of averaging the measured T wave characteristic magnitudes.

37. The method of claim 35 wherein the T wave characteristic baseline is a mean of the measured T wave characteristic magnitudes and wherein the method includes the further step of calculating the mean.

38. The method of claim 35 wherein the given number is one-fourth of the predetermined number.

39. The method of claim 35 including the further step of timing spaced apart times and wherein the generating step is performed at the spaced apart times.

40. The method of claim 35 including the further step of detecting when the patient is at rest and wherein the generating step is performed when the patient is at rest.

41. The method of claim 35 wherein the T wave characteristic is T wave amplitude and wherein the measuring step includes the step of measuring T wave amplitude magnitude of each T wave of the predetermined number of cardiac cycles.

42. The method of claim 35 wherein the implantable cardiac device includes pacing means for providing pacing pulses to the patient'"'"'s heart during paced cardiac cycles and wherein the measuring step is performed only for T waves occurring during paced cardiac cycles.

43. The method of claim 35 wherein the measuring step is performed on only intrinsic T waves.

44. The method of claim 35 wherein the predetermined number of cardiac cycles are consecutive cardiac cycles.

45. The method of claim 35 wherein the T wave characteristic is a T wave slope and wherein the measuring step includes the step of measuring a T wave slope magnitude of each T wave of the predetermined number of cardiac cycles.

46. The method of claim 35 wherein the T wave characteristic is T wave area and wherein the measuring step includes the step of measuring T wave area magnitude of each T wave of the predetermined number of cardiac cycles.

47. The method of claim 35 wherein the implantable cardiac device includes a lead system having a plurality of T wave sensing electrode configurations, and wherein the method further includes the step of selecting an electrode configuration from the plurality of T wave sensing electrode configurations that maximizes the measured T wave characteristic.

48. The method of claim 35 including the further step of transmitting to an external receiver the presence of a detected T wave alternan pattern.

49. The method of claim 35 including the further step of providing an indication, perceptible by the patient, of a detected T wave alternan pattern.

50. The method of claim 35 including the further step of storing in a memory at least one of heart rate, time of T wave alternan pattern detection, and patient activity level for the T wave alternan pattern detection.

51. The method of claim 35 including the further step of storing in a memory T wave characteristic histogram data.