Body electronic implant and artificial vision system thereof

• US 7,027,874 B1
• Filed: 11/16/2000
• Issued: 04/11/2006
• Est. Priority Date: 11/16/2000
• Status: Expired due to Fees

• Current Assignee: Polyvalor SEC
• Original Assignee: Polyvalor SEC
• Inventors: Savaria, Yvon, Roy, Martin, Sawan, Mohamad, Harvey, Jean-François, Donfack, Colince, Coulombe, Jonathan
• Primary Examiner(s): Manuel, George
• Assistant Examiner(s): Faulcon, Jr., Lenwood
• Application Number:
  US10/416,403
• Time in Patent Office: 1,972 Days
• Field of Search: 607/53, 607/116
• US Class Current: 607/116
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36046 of the eye

Abstract

A miniaturized body electronic implant for providing artificial vision to a blind person or for other uses as neuro-muscular sensors and microstimulators. The implant has a high resolution electrode array connected to a chip integrating implant stimulation and monitoring circuits, mounted on the back of the electrode array. The implant is powered by and communicates with an external unit through an inductive bi-directional link.

Claims

1. A body implant assembly comprising:

an electrode array having multiple adjacent electrodes directed towards respective stimulation sites;

an antenna;

a full custom mixed-signal chip including a transceiver circuit coupled to the antenna, an AC to DC transformation circuit coupled to the transceiver circuit and powering the full custom mixed-signal chip from energy contained in a control signal received by the transceiver circuit, a controller connected to the transceiver circuit and processing operation data contained in the control signal received by the transceiver circuit, and a stimuli generator circuit connected to the controller and generating stimulation signals in accordance with the operation data;

an electrode selection circuit connected to the stimuli generator circuit and having selectable outputs for transmission of the stimulation signals to selected ones of the electrodes in accordance with the operation data; and

a substrate support having a first side receiving the full custom mixed-signal chip, the antenna and the electrode selection circuit, and a second, opposite side receiving the electrode array, the first side having contacts lying around the full custom mixed-signal chip and connected to the outputs of the electrode selection circuit respectively, the second side having an array of adjacent contacts aligned with and connected to the electrodes respectively, the contacts on the first and second sides being interconnected respectively together by an interconnection circuit across the substrate support.

2. The body implant assembly according to claim 1, wherein the interconnection circuit comprises circuit layers made in the substrate support and stacked between the sides thereof, the circuit layers interconnecting the contacts on the first side with the contacts on the second side respectively.

3. The body implant assembly according to claim 1, wherein the contacts on the first side are distributed in an alternate shifted pattern over two adjacent sets of rows surrounding the full custom mixed-signal chip.

4. The body implant assembly according to claim 1, wherein:

the substrate support has a substantially flat front portion embedding the full custom mixed-signal chip and the electrode selection circuit, and a smaller rear portion projecting behind the front portion and receiving the electrode array, the first and second sides of the substrate support being on foremost and rearmost faces of the front and rear portions respectively;

the contacts on the first side project through and appear behind the front portion around the rear portion; and

the interconnection circuit comprises a series of peripheral contacts surrounding the array of adjacent contacts on the rearmost face of the rear portion, a wire bond interconnecting the peripheral contacts with the contacts appearing behind the front portion respectively, and circuit layers made in the rear portion and stacked between the rearmost face and a foremost face thereof, the circuit layers interconnecting the peripheral contacts with the array of adjacent contacts respectively.

5. The body implant assembly according to claim 1, wherein the full custom mixed-signal chip includes the electrode selection circuit.

6. The body implant assembly according to claim 1, wherein the antenna extend on the substrate support around the full custom mixed-signal chip.

7. The body implant assembly according to claim 1, wherein the full custom mixed-signal chip includes a monitoring circuit coupled between the electrode selection circuit and the controller, the monitoring circuit taking measurements of the stimulation signals in response to monitoring control signals issued by the controller depending on the operation data, and transmitting the measurements to the controller, the controller processing the measurements and transmitting test result signals to the transceiver circuit for emission out of the body implant depending on the operation data.

8. The body implant assembly according to claim 1, wherein the electrode array is made of biocompatible material, and has a 1 cm² cross-section, the electrodes comprising hundreds of needles distributed in rows and columns across the 1 cm² cross-section, and the substrate support has a thickness substantially less than 1 mm.

9. The body implant assembly according to claim 8, wherein the needles have an average height of 1, 5 mm and are spaced from one another by 400 μ

m.

10. A body implant comprising:

an electrode array having multiple adjacent electrodes directed towards respective stimulation sites;

an antenna;

a transceiver circuit coupled to the antenna;

an AC to DC voltage transformation circuit coupled to the transceiver circuit and providing implant power supply from energy contained in an implant control signal received by the transceiver circuit;

a controller connected to the transceiver circuit and processing operation data contained in the implant control signal received by the transceiver circuit;

a stimuli generator circuit connected to the controller and generating stimulation signals in accordance with the operation data; and

an electrode selection circuit connected between the stimuli generation circuit and the electrode array, the electrode selection circuit having selectable outputs for transmission of the stimulation signals to selected ones of the electrodes in accordance with the operation data;

the controller having a decoder circuit decoding the operation data contained in the implant control signal, a configuration controller storing common and specific stimulation parameters specified in the operation data and respectively addressed to all of the stimulation sites and specific ones of the stimulation sites, and a stimulation command controller transmitting stimulation control signals to the stimuli generator circuit in accordance with the common and specific stimulation parameters.

11. The body implant according to claim 10, wherein the controller further has a memory coupled between the configuration controller and the stimulation command controller, and storing a stimulation sequence specified in the operation data and representing an order of selection of the outputs of the electrode selection circuit for the stimulation signals respectively.

12. The body implant according to claim 10, wherein the common parameters comprise an amplitude of the stimulation signals, a duration of pulses in the stimulations signals, and a delay between two bipolar phases of the stimulation signals, the configuration controller storing an indication.

13. The body implant according to claim 10, wherein the decoder circuit comprises a frame detector detecting data frames contained in the implant control signal, and an error correction and command word decoder producing command words forming the operation data for the controller, the configuration controller and the stimulation command controller being connected to the error correction and command word decoder.

14. The body implant according to claim 10, wherein the transceiver circuit has an output producing a clock signal recovered from the implant control signal and transmitted to the controller as a timing base.

15. The body implant according to claim 10, wherein the controller has a power management module connected to the decoder circuit and to predetermined circuits of the body implant, for controllably turning said predetermined circuits on and off in accordance with the operation data.

16. A body implant comprising:

an electrode array having multiple adjacent electrodes directed towards respective stimulation sites;

an antenna;

a transceiver circuit coupled to the antenna;

an AC to DC voltage transformation circuit coupled to the transceiver circuit and providing implant power supply from energy contained in an implant control signal received by the transceiver circuit;

a controller connected to the transceiver circuit and processing operation data contained in the implant control signal received by the transceiver circuit;

a stimuli generator circuit connected to the controller and generating stimulation signals in accordance with the operation data;

an electrode selection circuit connected between the stimuli generation circuit and the electrode array, the electrode selection circuit having selectable outputs for transmission of the stimulation signals to selected ones of the electrodes in accordance with the operation data; and

a monitoring unit coupled between the controller and the electrode selection circuit, and controllably taking signal measurements at selected ones of the stimulation sites in response to monitoring control signals and producing test result signals indicative of the signal measurements;

the controller having a decoder circuit decoding the operation data contained in the implant control signal, a monitoring command generator decoding diagnosis instructions contained in the operation data and transmitting the monitoring control signals to the monitoring unit in accordance with the diagnosis instructions, and a diagnosis controller receiving and processing the test result signals from the monitoring unit.

17. The body implant according to claim 16, wherein the monitoring unit has an internal signal source module generating test signals used as the stimulation signals depending on the monitoring control signals, a current and voltage measuring circuit measuring a stimulation current and a monitored voltage across a monitored one of the stimulation sites in response to a corresponding one of the stimulation signals, a peak detector measuring a peak magnitude of the voltage, and a phase detector measuring a phase between the stimulation current and the monitored voltage, the test result signals being derived from the stimulation current, the monitored voltage and the phase.

18. The body implant according to claim 16, wherein the diagnosis controller is connected to the transceiver circuit, the test result signals being transmitted from the diagnosis controller to the transceiver circuit for emission out of the body implant depending on the operation data.

19. The body implant according to claim 18, wherein the diagnosis controller has connections with predetermined circuits of the implant to transmit test vectors contained in the operation data thereto and to receive resulting test result signals thereof.

20. A body implant comprising:

an electrode array having multiple adjacent electrodes directed towards respective measurement sites;

an antenna;

a transceiver circuit coupled to the antenna;

an AC to DC voltage transformation circuit coupled to the transceiver circuit and providing implant power supply from energy contained in an implant control signal received by the transceiver circuit;

a controller connected to the transceiver circuit and processing operation data contained in the implant control signal received by the transceiver circuit;

an electrode selection circuit connected to the electrode array, the electrode selection circuit having selectable outputs for communication with selected ones of the electrodes and the respective measurement sites; and

a monitoring unit coupled between the controller and the electrode selection circuit, and controllably taking signal measurements at the selected ones of the measurement sites in response to monitoring control signals and producing test result signals indicative of the signal measurements;

the controller having a decoder circuit decoding the operation data contained in the implant control signal, a monitoring command generator decoding diagnosis instructions contained in the operation data and transmitting the monitoring control signals to the monitoring unit in accordance with the diagnosis instructions, and a diagnosis controller receiving and processing the test result signals from the monitoring unit.

21. The body implant according to claim 20, wherein the monitoring unit has a current and voltage measuring circuit measuring a current and a voltage across a monitored one of the measurement sites, a peak detector measuring a peak magnitude of the voltage, and a phase detector measuring a phase between the current and the voltage, the test result signals being derived from the current, the voltage and the phase.

22. The body implant according to claim 20, wherein the diagnosis controller is connected to the transceiver circuit, the test result signals being transmitted from the diagnosis controller to the transceiver circuit for emission out of the body implant depending on the operation data.

23. A body implant comprising:

an electrode array having multiple adjacent electrodes directed towards respective stimulation sites;

an antenna;

a transceiver circuit coupled to the antenna;

an AC to DC voltage transformation circuit coupled to the transceiver circuit and providing implant power supply from energy contained in an implant control signal received by the transceiver circuit;

a controller connected to the transceiver circuit and processing operation data contained in the implant control signal received by the transceiver circuit;

a stimuli generator circuit connected to the controller and generating stimulation signals in accordance with the operation data; and

an electrode selection circuit connected between the stimuli generation circuit and the electrode array, the electrode selection circuit having selectable outputs grouped into channels for transmission of the stimulation signals to selected ones of the electrodes in accordance with the operation data;

the electrode selection circuit including, for each channel, a demultiplexer circuit connected to and operating switch arragements in accordance with site and polarity control signals, the switch arrangements being subjected to the stimulation signals and connected respectively to the outputs assigned to the channel;

the stimuli generator circuit including, for each channel, a signal generator controlled by a channel controller assisted by a timer connected to a register circuit receiving stimulation control signals, the signal generator producing the stimulation signals in accordance with the stimulation control signals, the register circuit and the channel controller producing the site and polarity control signals in accordance with the stimulation control signals; and

the controller having a decoder circuit decoding the operation data contained in the implant control signal, a configuration controller storing stimulation parameters specified in the operation data, and a stimulation command controller transmitting the stimulation control signals to the stimuli generator circuit in accordance with the stimulation parameters.

24. The body implant according to claim 23, wherein each register circuit comprises first and second sets of registers, one of which being used to load the stimulation control signals for a next stimulation while the other one being used to provide the stimulation control signals for a current stimulation.

25. The body implant according to claim 23, wherein each signal generator comprises a digital to analog converter producing an analog current signal forming one of the stimulation signals.

26. The body implant according to claim 23, further comprising:

a monitoring unit coupled between the controller and the electrode selection circuit, and controllably taking measurements of selected ones of the stimulation signals in response to monitoring control signals and producing test results signals indicative of the measurements;

and wherein;

the electrode selection circuit further includes, for each channel, a multiplexer circuit connected to the outputs assigned to the channel for selective monitoring thereof by the monitoring unit depending on a monitoring channel signal; and

the controller includes a monitoring command generator decoding diagnosis instructions contained in the operation data and transmitting the monitoring control signals to the monitoring unit and the monitoring channel signal to the electrode selection circuit in accordance with the diagnosis instructions, and a diagnosis controller receiving and processing the test result signals from the monitoring unit.

27. The body implant according to claim 26, wherein the monitoring unit comprises a peak detector measuring a highest amplitude level of a monitored one of the stimulation signals, and a comparator producing an overflow signal when the highest amplitude level exceed a predetermined safety threshold, the overflow signal being reported to the diagnosis controller for processing thereof.