Cardiac rhythm management systems and methods using multiple morphology templates for discriminating between rhythms

• US 7,031,764 B2
• Filed: 11/08/2002
• Issued: 04/18/2006
• Est. Priority Date: 11/08/2002
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Schwartz, Mark, Kim, Jaeho, Bocek, Joseph M.
• Primary Examiner(s): Pezzuto, Robert E.
• Assistant Examiner(s): JOHNSON, SHEVON ELIZABETH
• Application Number:
  US10/291,200
• Publication Number:
  US 20040093035A1
• Time in Patent Office: 1,257 Days
• Field of Search: 607/14, 607/5, 607/4, 607/9, 600/510, 600/518, 600/520, 600/519
• US Class Current: 600/518
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

Multiple morphology templates for discliminating between rhythms have been used, such as supraventricular tachyarrhythmias (SVTs) and ventricular tachyarrhythmias (VTs), for delivering a countershock in response to a VT episode, but withholding delivery of such a countershock in response to an SVT episode. In certain examples, the particular morphology used for storing morphological features is selected at least in part using a sensor-indicated activity level of a subject, or a metabolic need of the subject.

Claims

1. A system comprising:

an electrogram sensing circuit, configured to be coupled to at least one electrode for receiving an intrinsic cardiac signal, the electrogram sensing circuit configured to provide cardiac complexes and an indication of heart rate obtained from a subject'"'"'s heart;

a stored first morphological template, coupled to the electrogram sensing circuit, the stored first morphological template obtained from the heart, in the absence of an arrhythmia, while the subject is resting or inactive;

a stored second morphological template, coupled to the electrogram sensing circuit, the stored second morphological template obtained from the heart under a condition different from that of the first morphological template;

a correlation module, coupled to the first and second morphological templates and the electrogram sensing circuit, the correlation module configured to declare an indication of a first rhythm state if the indication of heart rate exceeds a first predetermined threshold value and a morphology of at least one cardiac complex of the intrinsic cardiac signal correlates to either of the first and second morphological templates, and configured to declare an indication of a second rhythm state if the indication of heart rate exceeds the first predetermined threshold value and a morphology of the at least one cardiac complex of the intrinsic cardiac signal is uncorrelated to both the first and second morphological templates.

2. The system of claim 1, in which the first rhythm state is a supraventricular tachyarrhythmia (SVT) and the second rhythm state is a ventricular tachyarrhythmia.

3. The system of claim 1, further comprising a sensor configured to detect at least one of an activity of the subject and a metabolic need of the subject.

4. The system of claim 3, in which the second morphological template is coupled to the sensor such that the second morphological template is obtained from the subject'"'"'s heart during a period of exercise indicated by the sensor.

5. The system of claim 1, in which the second morphological template is obtained under a supraventricular tachyarrhythmia (SVT) condition and the first morphological template is obtained under a resting normal sinus rhythm condition.

6. The system of claim 1, further comprising at least one electrode.

7. The system of claim 1, further comprising a remote user interface configured to be communicatively coupled to an implantable device.

8. The system of claim 1, further comprising a template updating control module, coupled to at least one of the first and second morphological templates to occasionally update the at least one of the first and second morphological templates.

9. The system of claim 8, further comprising a sensor including a sensor output configured to provide an indication of at least one of an activity of the subject and a metabolic need of the subject, and in which the template updating control module is coupled to the sensor, and in which the template updating control module selects between the first and second morphological templates for updating using the sensor output.

10. The system of claim 1, in which the correlation module declares the indication of the second rhythm state if the indication of heart rate exceeds a second predetermined threshold value, which is greater than the first predetermined threshold value, regardless of whether the morphology of the at least one cardiac complex of the intrinsic cardiac signal correlates to either of the first and second morphological templates.

11. The system of claim 1, in which at least one of the stored first and second morphological templates is obtained using previously obtained electrogram data that is stored in a memory coupled to the electrogram sensing circuit.

12. The system of claim 1, in which the stored second morphological template includes a plurality of morphological templates.

13. A system comprising:

an electrogram sensing circuit, configured to be coupled to at least one electrode for receiving an intrinsic cardiac signal, the electrogram sensing circuit configured to provide cardiac complexes and an indication of heart rate obtained from a subject'"'"'s heart;

a stored first morphological template, coupled to the electrogram sensing circuit, the stored first morphological template obtained from the heart, in the absence of an arrhythmia, while the subject is resting or inactive;

a stored second morphological template, coupled to the electrogram sensing circuit, the stored second morphological template obtained from the heart under a condition different from that of the first morphological template;

a means, coupled to the first and second morphological templates and the electrogram sensing circuit, for declaring an indication of a first rhythm state if the indication of heart rate exceeds a first predetermined threshold value and a morphology of at least one cardiac complex of the intrinsic cardiac signal correlates to either of the first and second morphological templates;

a means, coupled to the first and second morphological templates and the electrogram sensing circuit, for declaring an indication of a second rhythm state if the indication of heart rate exceeds the first predetermined threshold value and a morphology of the at least one cardiac complex of the intrinsic cardiac signal is uncorrelated to both the first and second morphological templates.

14. A system comprising:

an electrogram sensing circuit, configured to be coupled to at least one electrode for receiving an intrinsic cardiac signal, the electrogram sensing circuit configured to provide cardiac complexes and an indication of heart rate obtained from a subject'"'"'s heart;

a stored first morphological template, coupled to the electrogram sensing circuit, the stored first morphological template obtained from the heart, in the absence of an arrhythmia, while the subject is resting or inactive;

a stored second morphological template, coupled to the electrogram sensing circuit, the stored second morphological template obtained from the heart under a condition different from that of the first morphological template; and

a correlation module, coupled to the electrogram sensing circuit and the first and second morphological templates, the correlation module configured to discriminate between first and second rhythm states using a comparison of a morphology of at least one cardiac complex of the intrinsic cardiac signal to at least one of the first and second morphological templates, the at least one of the first and second morphological templates selected using the indication of heart rate provided by the electrogram sensing circuit.

15. The system of claim 14, further comprising:

a shock circuit, configured to be coupled to at least one electrode for delivering a shock to the heart; and

a shock control module, coupled to the correlation module and the shock circuit, the shock control module configured to trigger a shock if the correlation module declares the indication of the second rhythm state, and the shock control module configured to inhibit a shock if the correlation module declares the indication of the first rhythm state.

16. The system of claim 14, in which the correlation module includes first and second predetermined threshold values, the second predetermined threshold value representing a higher heart rate than the first predetermined threshold value and:

in which the correlation module is configured to declare an indication of a first rhythm state if the indication of heart rate exceeds the first predetermined threshold value and is less than the second predetermined threshold value and a morphology of at least one cardiac complex of the intrinsic cardiac signal correlates to either of the first and second morphological templates; and

in which the correlation module is configured to declare an indication of a second rhythm state if at least one of;

the indication of heart rate exceeds the second predetermined threshold value; and

the indication of heart rate exceeds the first predetermined threshold value and is less than the second predetermined threshold value and a morphology of the at least one cardiac complex of the intrinsic cardiac signal is uncorrelated to both the first and second morphological templates.

17. The system of claim 14, further comprising:

a first electrode, sized and shaped for being implanted in or near the heart, the first electrode configured for sensing a heart rate from cardiac complexes; and

a second electrode, sized and shaped for being implanted in or near the heart, the second electrode configured for sensing a morphology of a cardiac complex.

18. A system comprising:

an electrogram sensing circuit, configured to be coupled to at least one electrode for receiving an intrinsic cardiac signal, the electrogram sensing circuit configured to provide cardiac complexes and an indication of heart rate obtained from a subject'"'"'s heart;

a stored first morphological template, coupled to the electrogram sensing circuit, the stored first morphological template obtained from the heart, in the absence of an arrhythmia, while the subject is resting or inactive;

a stored second morphological template, coupled to the electrogram sensing circuit, the stored second morphological template obtained from the heart under a condition different from that of the first morphological template; and

a means, coupled to the electrogram sensing circuit and the first and second morphological templates, for discriminating between first and second rhythm states using a comparison of a morphology of at least one cardiac complex of the intrinsic cardiac signal to at least one of the first and second morphological templates, the at least one of the first and second morphological templates selected using the indication of heart rate provided by the electrogram sensing circuit.

19. A system comprising:

a first electrode, sized and shaped for being implanted in or near a subject'"'"'s heart, the first electrode configured for sensing a heart rate from cardiac complexes;

a second electrode, sized and shaped for being implanted in or near the heart, the second electrode configured for sensing a morphology of a cardiac complex;

an electrogram sensing circuit, configured to be coupled to the first and second electrodes for receiving respective first and second intrinsic cardiac signals, the electrogram sensing circuit configured to provide cardiac complexes and an indication of heart rate obtained from the heart;

a sensor, including a sensor output indicative of activity or metabolic need of the subject;

a stored first morphological template, coupled to the electrogram sensing circuit, the stored first morphological template obtained from the heart in the absence of an arrhythmia while the subject is resting or inactive;

a stored second morphological template, coupled to the electrogram sensing circuit and the sensor, the stored second morphological template obtained from the heart under a different sensor output condition from that of the first morphological template;

a correlation module, coupled to the first and second morphological templates, the correlation module including first and second predetermined thresholds, the second predetermined threshold representing a higher heart rate value than the first predetermined threshold, the correlation module configured to declare a supraventricular tachyarrhythmia (SVT) if the heart rate value exceeds the first predetermined threshold but is less than the second predetermined threshold and a morphology of at least one cardiac complex of second intrinsic cardiac signal correlates to either of the first and second morphological templates, and configured to declare a ventricular tachyarrhythmia (VT) if at least one of;

(a) the heart rate value exceeds the second predetermined threshold; and

(b) the heart rate value exceeds the first predetermined threshold but is less than the second predetermined threshold and a morphology of the at least one cardiac complex of the second intrinsic cardiac signal is uncorrelated to both the first and second morphological templates.

20. The system of claim 19, further comprising a template updating control module, coupled to at least one of the first and second morphological templates to occasionally update the at least one of the first and second morphological templates.

21. The system of claim 20, in which the template updating control module is coupled to the sensor output, and in which the template updating control module selects between the first and second morphological templates for updating using the sensor output.

22. A system comprising:

a first electrode, sized and shaped for being implanted in or near a subject'"'"'s heart, the first electrode configured for sensing a heart rate from cardiac complexes;

a second electrode, sized and shaped for being implanted in or near the heart, the second electrode configured for sensing a morphology of a cardiac complex;

an electrogram sensing circuit, configured to be coupled to the first and second electrodes for receiving respective first and second intrinsic cardiac signals, the electrogram sensing circuit configured to provide cardiac complexes and an indication of heart rate obtained from the heart;

a sensor, including a sensor output indicative of activity or metabolic need of the subject;

a stored first morphological template, coupled to the electrogram sensing circuit, the stored first morphological template obtained from the heart in the absence of an arrhythmia while the subject is resting or inactive;

a stored second morphological template, coupled to the electrogram sensing circuit and the sensor, the stored second morphological template obtained from the heart under a different sensor output condition from that of the first morphological template;

a means, coupled to the first and second morphological templates, for declaring a supraventricular tachyarrhythmia (SVT) if (1) the heart rate value exceeds a first predetermined threshold but is less than a second predetermined threshold and (2) a morphology of at least one cardiac complex of second intrinsic cardiac signal correlates to either of the first and second morphological templates;

a means, coupled to the first and second morphological templates, for declaring a ventricular tachyarrhythmia (VT) if at least one of;

(a) the heart rate value exceeds the second predetermined threshold; and

(b) the heart rate value exceeds the first predetermined threshold but is less than the second predetermined threshold and a morphology of the at least one cardiac complex of the second intrinsic cardiac signal is uncorrelated to both the first and second morphological templates.

23. A method comprising:

obtaining a first morphological template from a subject'"'"'s heart in the absence of an arrhythmia, while the subject is resting or inactive;

obtaining a second morphological template from the heart under a condition different from that of the first morphological template;

obtaining at least one cardiac complex;

determining a degree of correlation between the at least one cardiac complex and at least one of the first and second morphological templates; and

declaring one of first and second rhythm states at least in part using the determined degree of correlation.

24. The method of claim 23, further including determining whether to deliver or inhibit a shock to a heart at least in part using which of the first and second rhythm states was declared.

25. The method of claim 23, in which the obtaining the second morphological template occurs under a condition in which the subject manifests at least one activity indicator value that is higher than the at least one activity indicator value occurring during the obtaining the first morphological template.

26. The method of claim 23, in which the obtaining the second morphological template occurs under a condition in which the subject manifests an arrhythmia.

27. The method of claim 26, in which the obtaining the second morphological template occurs under a condition in which the subject manifests an induced arrhythmia.

28. The method of claim 23, in which the obtaining the second morphological template occurs under a condition in which the subject manifests a supraventricular tachyarrhythmia.

29. The method of claim 23, in which the declaring one of first and second rhythm states at least in part using the determined degree of correlation comprises:

obtaining an indication of heart rate;

declaring the first rhythm state if the indication of heart rate exceeds a first predetermined threshold value and a morphology of the at least one cardiac complex correlates to either of the first and second morphological templates; and

declaring the second rhythm state if the indication of heart rate exceeds the first predetermined threshold value and a morphology of the at least one cardiac complex is uncorrelated to both the first and second morphological templates.

30. The method of claim 23, in which the declaring one of first and second rhythm states at least in part using the determined degree of correlation comprises:

obtaining an indication of heart rate;

declaring the first rhythm state if;

(a) the indication of heart rate exceeds a first predetermined threshold value but is less than a second predetermined threshold value, in which the second predetermined threshold value represents a higher heart rate than the first predetermined threshold value, and (b) a morphology of the at least one cardiac complex correlates to either of the first and second morphological templates; and

declaring the second rhythm state if;

(a) the indication of heart rate exceeds the first predetermined threshold value but is less than the second predetermined threshold value, and (b) a morphology of the at least one cardiac complex is uncorrelated to both the first and second morphological templates.

31. The method of claim 23, in which the determining the degree of correlation between the at least one cardiac complex and the at least one of the first and second morphological templates comprises:

obtaining an indication of heart rate; and

selecting between the first and second morphological templates at least in part using the indication of heart rate.

32. The method of claim 23, further comprising at least occasionally updating at least one of the first and second morphological templates.

33. The method of claim 32, in which the at least occasionally updating at least one of the first and second morphological templates comprises:

obtaining at least one sensor value selected from the group consisting of an accelerometer-based sensor value and a metabolic need sensor value; and

selecting between updating the first and second morphological templates at least in part using the at least one sensor value.

34. A system comprising:

means for obtaining a first morphological template from a subject'"'"'s heart in the absence of an arrhythmia, while the subject is resting or inactive;

means for obtaining a second morphological template from the heart under a condition different from that of the first morphological template;

means for obtaining at least one cardiac complex;

means for determining a degree of correlation between the at least one cardiac complex and at least one of the first and second morphological templates; and

means for declaring one of first and second rhythm states at least in part using the determined degree of correlation.