Algorithms for detecting atrial arrhythmias from discriminatory signatures of ventricular cycle lengths
First Claim
1. A method of detecting atrial arrhythmias, comprising one or more of atrial fibrillation (AF) and atrial flutter (AFL) within a segment of ventricular heartbeats signified by intervals between successive ventricular heartbeats that exhibit discriminatory signatures when plotted as data points in a scatter-plot comprising:
- defining an AF signature metric for AF representative of the sparse distribution of data points during AF episodes and an AFL signature metric representative of the clustering distribution of data points during AFL episodes;
determining each interval between successive ventricular heartbeats;
plotting each succeeding interval as a data point in a scatter-plot;
developing a discriminatory metric signifying the degree of sparseness or clustering of the data points of the scatter-plot;
declaring AF if the discriminatory metric satisfies the AF signature metric representative of the distribution of data points during AF; and
declaring AFL if the discriminatory metric satisfies the AFL signature metric representative of the distribution of data points during AFL.
1 Assignment
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Accused Products
Abstract
Detection of arrhythmias is facilitated using irregularity of ventricular beats measured by delta-RR (ΔRR) intervals that exhibit discriminatory signatures when plotted in a Lorenz scatter-plot. An “AF signature metric” is established characteristic of episodes of AF that exhibit highly scattered (sparse) distributions or formations of 2-D data points. An “AFL signature metric” is established characteristic of episodes of AFL that exhibit a highly concentrated (clustered) distribution or formation of 2-D data points. A set of heart beat interval data is quantified to generate highly scattered (sparse) formations as a first discrimination metric and highly concentrated (clustered) distributions or formations as a second discrimination metric. The first discrimination metric is compared to the AF signature metric, and/or the second discrimination metric is compared to the AFL signature metric. AF or HFL is declared if the first discrimination metric satisfies either one of the AF signature metric.
99 Citations
41 Claims
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1. A method of detecting atrial arrhythmias, comprising one or more of atrial fibrillation (AF) and atrial flutter (AFL) within a segment of ventricular heartbeats signified by intervals between successive ventricular heartbeats that exhibit discriminatory signatures when plotted as data points in a scatter-plot comprising:
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defining an AF signature metric for AF representative of the sparse distribution of data points during AF episodes and an AFL signature metric representative of the clustering distribution of data points during AFL episodes; determining each interval between successive ventricular heartbeats; plotting each succeeding interval as a data point in a scatter-plot; developing a discriminatory metric signifying the degree of sparseness or clustering of the data points of the scatter-plot; declaring AF if the discriminatory metric satisfies the AF signature metric representative of the distribution of data points during AF; and declaring AFL if the discriminatory metric satisfies the AFL signature metric representative of the distribution of data points during AFL. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. Apparatus for detecting atrial arrhythmias, comprising one or more of atrial fibrillation (AF) and atrial flutter (AFL) within a segment of ventricular heartbeats signified by intervals between successive ventricular heartbeats that exhibit discriminatory signatures when plotted as data points in a scatter-plot comprising:
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means for defining an AF signature metric for AF representative of the sparse distribution of data points during AF episodes and an AFL signature metric representative of the clustering distribution of data points during AFL episodes; means for determining each interval between successive ventricular heartbeats; means for plotting each succeeding interval as a data point in a scatter-plot; means for developing a discriminatory metric signifying the degree of sparseness or clustering of the data points of the scatter-plot; means for declaring AF if the discriminatory metric satisfies the AF signature metric representative of the distribution of data points during AF; and means for declaring AFL if the discriminatory metric satisfies the AFL signature metric representative of the distribution of data points during AFL. - View Dependent Claims (37, 38)
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39. A processor readable medium containing instructions to cause the processor to utilize ventricular signals to access atrial patterns for monitoring, diagnosis and prediction in the treatment of atrial arrhythmias comprising:
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determining each interval between successive ventricular heartbeats comprising; plotting each succeeding interval as a data point in a scatter-plot having an origin; developing a metric signifying the degree of sparseness or clustering of the data points within the scatter-plot and with respect to the origin; defining one or more of a sparseness discriminatory signature of data points in the scatter-plot representative of the distribution of data points with respect to origin during AF and a clustering discriminatory signature of data points in the scatter-plot representative of the distribution of data points with respect to origin during AFL; and declaring one or more of AF or AFL if the metric exhibits the sparseness discriminatory signature representative of the distribution of data points during AF and of AFL if the metric exhibits the clustering discriminatory signature representative of the distribution of data points during AFL. - View Dependent Claims (40, 41)
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Specification