Ultrasonic water content monitor and methods for monitoring tissue hydration

• US 7,033,321 B1
• Filed: 10/25/2004
• Issued: 04/25/2006
• Est. Priority Date: 10/25/2004
• Status: Expired due to Fees

• Current Assignee: Artann Laboratories Inc.
• Original Assignee: Artann Laboratories Inc.
• Inventors: Sarvazyan, Armen P.
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US10/979,940
• Time in Patent Office: 547 Days
• Field of Search: 600/438, 600/449, 600/456, 735/97
• US Class Current: 600/449
• CPC Class Codes: A61B 5/1075 for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer A61B8/0858 takes precedence
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 5/6828 Leg
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/4227 characterised by straps, belts, cuffs or braces
• CPC Class Codes: A61B 8/4427 Device being portable or laptop-like

Abstract

A device and method for determining the hydration and water content status of soft biological tissue is disclosed and includes a couple of ultrasonic transducers located at a known distance therebetween and held against the tissue of interest as well as an adjustable support system with angle measuring means necessary for evaluation of ultrasound velocity in this tissue. Based on the time-of-flight results of the ultrasound velocity measurement, the water content in the tested tissue is evaluated and the hydration status is determined. One embodiment of the invention is a wearable device attached to human calf measuring water content in muscle.

Claims

1. An ultrasonic tissue water content monitor comprising:

a first ultrasonic means,

a second ultrasonic means, and

an adjustable support system to hold said first ultrasonic means and said second ultrasonic means against said tissue at a known distance therebetween, said adjustable support system including;

a first bearing tube having a first end and a second end and defining a first distance therebetween, said first end supporting said first ultrasonic means,

a second bearing tube having a first end and a second end and defining a second distance therebetween, said first end supporting said second ultrasonic means, and

a rotary hinge with an angle sensor, said hinge attached to said second end of said first bearing tube and said second end of said second bearing tube to hingedly connect said both bearing tubes, said angle sensor providing angle information of said first bearing tube relative to said second bearing tube,

whereby the distance between said first and second ultrasonic means can be calculated from said known first distance, said second distance and said angle information.

2. The monitor as in claim 1 further equipped with an elastic strap to hold said adjustable support system and said first and second ultrasonic means about said tissue.

3. The monitor as in claim 1, wherein said first ultrasonic means is an ultrasonic transmitter and said second ultrasonic means is an ultrasonic receiver.

4. The monitor as in claim 1, wherein said first ultrasonic means is an ultrasonic transducer and said second ultrasonic means is an ultrasonic reflecting plate.

5. The monitor as in claim 1, wherein said adjustable support system further equipped with an adjustable strap means to complete the loop about said tissue for attaching said monitor thereto.

6. The monitor as in claim 1, wherein said rotary hinge equipped with a flat sprig and said angle sensor comprising a strain gage attached to said flat spring.

7. The monitor as in claim 1 further equipped with a tissue temperature sensor.

8. A method of evaluating water content in tissue comprising the steps of:

(a) providing a first ultrasonic means held against said tissue on one side of a predetermined measurement pathway, and a second ultrasonic means held against said tissue on the other side of said predetermined measurement pathway, said second ultrasonic means located at a known distance from said first ultrasonic means, said predetermined measurement pathway selected to traverse only a portion of said tissue in which velocity of ultrasound wave pulse propagation is substantially uniform therethrough.

(b) transmitting an ultrasound wave pulse across said tissue from said first ultrasonic means to said second ultrasonic means,

(c) detecting time-of-flight of said wave pulse between said first and said second ultrasonic means;

(d) calculating ultrasonic velocity of said wave pulse through said tissue from said time-of-flight and said distance between said first and said second ultrasonic means; and

(e) calculating water content of said tissue from said calculated ultrasonic velocity.

9. The method as in claim 8 further comprising the steps of:

(f) measuring tissue temperate, and

(g) correcting the water content value from step (e) by a factor defined by said tissue temperature.

10. The method as in claim 8, wherein step (a) further including providing an adjustable support system to hold said first ultrasonic means and said second ultrasonic means against said tissue at said known distance therebetween.

11. The method as in claim 8, wherein said tissue is soleus muscle.

12. The method as in claim 8, further including a step of transmitting said calculated water content to a remote location.

13. The method as in claim 12, wherein said transmitting step including a wireless transmission.

14. A method of evaluating water content in tissue comprising the steps of:

(a) providing a first ultrasonic means held against said tissue on one side of a predetermined measurement pathway, and a second ultrasonic means held against said tissue on the other side of said predetermined measurement pathway, said second ultrasonic means located at a known distance from said first ultrasonic means, said predetermined measurement pathway selected to traverse at least two layers of said tissue, each layer characterized by velocity of ultrasound wave pulse propagation being substantially uniform therethrough;

(b) transmitting an ultrasound wave pulse across said tissue from said first ultrasonic means to said second ultrasonic means;

(c) detecting a plurality of time-of-flight measurements of said wave pulse within each layer of said tissue;

(d) calculating a plurality of ultrasonic velocity measurements of said wave pulse through each layer of said tissue from said time-of-flight measurements and said distance between said first and said second ultrasonic means; and

(e) calculating water content of said tissue from said calculated ultrasonic velocity.

15. The method as in claim 14, wherein said steps (c) through (e) are done using an A-mode pulse-echo ultrasonic measurement method.