Tubular prosthesis for external agent delivery

• US 7,033,389 B2
• Filed: 10/16/2001
• Issued: 04/25/2006
• Est. Priority Date: 10/16/2001
• Status: Expired due to Fees

• Current Assignee: Lifeshield Sciences LLC (Acacia Research Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Sherry, John E.
• Primary Examiner(s): HO, UYEN T
• Application Number:
  US09/978,988
• Publication Number:
  US 20030074048A1
• Time in Patent Office: 1,652 Days
• Field of Search: 623/1.13, 623 142- 148
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/89 the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
• CPC Class Codes: A61F 2002/065 Y-shaped blood vessels
• CPC Class Codes: A61F 2250/0003 having an inflatable pocket filled with fluid, e.g. liquid or gas
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir

Abstract

A tubular prosthesis, which may be an endovascular prothesis, is provided which includes a tubular member (stent or stent/graft combination) and an outer covering having portions sealed to the tubular member. The tubular member is impervious to a pre-determined fluid, particularly an occluding fluid, while the outer cover is pervious to the pre-determined fluid. In one aspect of the present invention, the implantation of the prosthesis allows for occluding fluid to weep from the prosthesis and into a sac of an aneurysm to cause occlusion thereof without introducing the occluding fluid into the blood stream. In this manner, a Type II failure of the prosthesis may be avoided. In other aspects of the invention, therapeutic agents may be delivered and/or a seal may be formed about the prosthesis to prevent a Type I failure.

Claims

1. A tubular prosthesis comprising:

a prosthetic tubular member having a wall with an inner surface and an outer surface, said wall being impervious to transmission therethrough of a pre-determined fluid;

an outer covering having portions sealed to said outer surface of said tubular member, said outer cover being pervious to transmission therethrough of said pre-determined fluid; and

a fluid conduit having an end communicating with space defined between said tubular member and said outer covering, said fluid conduit formed to convey said pre-determined fluid to said space, wherein said outer covering is increasingly pervious to transmission therethrough of said predetermined fluid at locations increasingly further from said end of said fluid conduit.

2. A prosthesis as in claim 1, wherein said tubular member is formed of a polymeric material.

3. A prosthesis as in claim 1, wherein said tubular member is formed of a textile material.

4. A prosthesis as in claim 1, wherein said tubular member includes a polymeric material and a textile material.

5. A prosthesis as in claim 1, wherein said outer covering is generally coextensive with said tubular member.

6. A prosthesis as in claim 1, wherein said tubular member has a first opening, said outer covering being sealed to said tubular member in proximity to said first opening.

7. A prosthesis as in claim 1, wherein said tubular member is cylindrical.

8. A prosthesis as in claim 1, wherein said tubular member is generally Y-shaped with a single lumen being in fluid communication with two minor lumens.

9. A prosthesis as in claim 1, wherein said outer covering is a porous material.

10. A prosthesis as in claim 1, wherein cut apertures are formed in said outer covering.

11. A prosthesis as in claim 10, wherein said cut apertures are each generally equal in size.

12. A prosthesis as in claim 10, wherein said cut apertures are of various sizes.

13. A prosthesis as in claim 10, wherein said cut apertures are unevenly dispersed.

14. A prosthesis as in claim 1, wherein said end of said fluid conduit directly communicates with said space with said end being located in said space.

15. A prosthesis as in claim 1, wherein said end indirectly communicates with said space via a valve.

16. A prosthesis as in claim 1, wherein cut apertures are formed in said outer covering, said cut apertures being increasingly larger as located increasingly further located from said end of said fluid conduit.

17. A prosthesis as in claim 1, wherein cut apertures are formed in said outer covering, the density of said cut apertures increasing with distance from said end of said fluid conduit.

18. A prosthesis as in claim 1, wherein said outer covering is increasingly porous at locations increasingly further from said end of said fluid conduit.

19. A prosthesis as in claim 1, wherein said pre-determined fluid is an occluding fluid.

20. A prosthesis as in claim 19, wherein said occluding fluid is an embolic liquid selected from the group consisting of alginates, hyaluronic acid, cyanoacrylates, and admixtures thereof.

21. A prosthesis as in claim 19, wherein said occluding fluid is selected from the group consisting of sclerosing agents, polyurethanes, silicones, and admixtures thereof.

22. A prosthesis as in claim 19, wherein said occluding fluid includes thrombin.

23. A prosthesis as in claim 19, wherein said occluding fluid includes an autologous clot.

24. A prosthesis as in claim 1, wherein said tubular member is a graft.

25. A prosthesis as in claim 1, wherein said tubular member is a stent/graft combination.

26. A prosthesis as in claim 25, wherein said stent is expandable.

27. A prosthesis as in claim 26, wherein said stent is self-expanding.

28. A prosthesis as in claim 1, wherein said sealed portions of said outer covering at least partially bound a pocket for receiving said pre-determined fluid.

29. A prosthesis as in claim 28, wherein said pocket is generally coextensive with said tubular member.

30. A prosthesis as in claim 1, wherein said pre-determined fluid is a therapeutic agent.

31. A prosthesis as in claim 1, wherein the prosthesis is an endovascular prosthesis.