Systems and methods using multiple solvents for the removal of lipids from fluids

• US 7,033,500 B2
• Filed: 06/21/2002
• Issued: 04/25/2006
• Est. Priority Date: 06/25/2001
• Status: Expired due to Fees

• Current Assignee: Eli Lilly and Company, Lipid Sciences, Inc.
• Original Assignee: Lipid Sciences, Inc.
• Inventors: Garcia, Pablo E., Chavez, Bryan, Hegwer, Eric, Malhotra, Ripudaman, Low, Thomas P., Shimon, Jeffrey J., Bomberger, David C.
• Primary Examiner(s): Walker, W. L.
• Assistant Examiner(s): Menon, Krishnan S.
• Application Number:
  US10/178,900
• Publication Number:
  US 20030150809A1
• Time in Patent Office: 1,404 Days
• Field of Search: 210/252, 210/253, 210/255, 210/257.2, 210/263, 210/321.79, 210/321.8, 210/645, 210/649, 210/660, 210804-807, 604/5.03
• US Class Current: 210/321.79
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/3403 Regulation parameters
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 1/3482 by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
• CPC Class Codes: A61M 1/3486 Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: A61M 1/3496 Plasmapheresis; Leucopheresis; Lymphopheresis A61M1/3472 takes precedence
• CPC Class Codes: A61M 1/3616 Batch-type treatment
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 2202/0456 Lipoprotein
• CPC Class Codes: A61M 2202/08 Lipoids
• CPC Class Codes: A61M 2202/203 Bacteria
• CPC Class Codes: A61M 2202/206 Viruses
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: B01D 61/362 Pervaporation

Abstract

This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.

Claims

1. A device for removing at least one lipid from a fluid containing lipids or lipid-containing organisms, comprising:

a fluid source containing the fluid and coupled to at least one hollow fiber contactor;

a first extraction solvent source containing a first extraction solvent and coupled to the at least one hollow fiber contactor;

the at least one hollow fiber contactor that receives the fluid from the fluid source and the first extraction solvent from the first extraction solvent source, forming a first mixture and dissolving at least a portion of the lipids;

a second extraction solvent source containing a second extraction solvent and coupled to a first solvent removal apparatus;

the first solvent removal apparatus coupled to the at least one hollow fiber contactor, wherein the first solvent removal apparatus receives the first mixture from the at least one hollow fiber contactor and the second extraction solvent from the second extraction solvent source, forming a second mixture and dissolving additional lipids and at least a portion of the first extraction solvent; and

a second solvent removal apparatus that is coupled to the first solvent removal apparatus and receives the second mixture and removes at least a portion of any remaining solvents from the second mixture.

2. The device of claim 1, wherein the first solvent removal apparatus comprises at least one hollow fiber contactor.

3. The device of claim 1, wherein the first solvent removal apparatus comprises at least one drip through column.

4. The device of claim 3, wherein the first solvent removal apparatus comprises at least one vortexer.

5. The device of claim 3, wherein the first solvent removal apparatus comprises at least one centrifuge.

6. The device of claim 1, wherein first solvent removal apparatus comprises at least one in-line static-mixer.

7. The device of claim 1, wherein the first solvent removal apparatus comprises at least one vortexer.

8. The device of claim 1, wherein the second solvent removal apparatus comprises at least one hollow fiber contactor.

9. The device of claim 8, wherein the second solvent removal apparatus comprises at least two hollow fiber contactors coupled together in parallel.

10. The device of claim 8, wherein the second solvent removal apparatus comprises at least two hollow fiber contactors coupled together in series.

11. A device for removing at least one lipid from a fluid containing lipids or lipid-containing organisms, comprising:

a fluid source containing the fluid and coupled to a first apparatus;

a first extraction solvent source containing a first extraction solvent and coupled to the first apparatus;

the first apparatus that receives the fluid from the fluid source and the first extraction solvent from the first extraction solvent source, forming a first mixture and dissolving at least a portion of the lipids;

a second extraction solvent source containing a second extraction solvent and coupled to at least one hollow fiber contactor;

the at least one hollow fiber contactor coupled to the first apparatus, wherein the at least one hollow fiber contactor receives the first mixture from the first apparatus and the second extraction solvent from the second extraction solvent source, forming a second mixture and dissolving additional lipids and at least a portion of the first extraction solvent; and

a second apparatus that is coupled to the at least one hollow fiber contactor and receives the second mixture and removes at least a portion of any remaining solvents from the second mixture.

12. The device of claim 11, wherein the first apparatus comprises at least one hollow fiber contactor.

13. The device of claim 11, wherein the first apparatus comprises at least one drip through column.

14. The device of claim 11, wherein the first apparatus comprises at least one in-line static-mixer.

15. The device of claim 11, wherein the first apparatus comprises at least one vortexer.

16. The device of claim 11, wherein the second apparatus comprises at least one hollow fiber contactor.

17. The device of claim 16, wherein the second apparatus comprises at least two hollow fiber contactors coupled together in parallel.

18. The device of claim 16, wherein the second apparatus comprises at least two hollow fiber contactors coupled together in series.