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Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)

  • US 7,034,009 B2
  • Filed: 05/03/2002
  • Issued: 04/25/2006
  • Est. Priority Date: 10/26/1995
  • Status: Expired due to Term
First Claim
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1. A compound having Formula II:

  • (SEQ ID NO;

         13488)5′

    -usascs asau ucU GAu Gag gcg aaa gcc Gaa Aag aca aB-3′

    wherein each a is 2′

    -O-methyl adenosine nucleotide, each g is a 2′

    -O-methyl guanosine nucleotide, each c is a 2′

    -O-methyl cytidine nucleotide, each u is a 2′

    -O-methyl uridine nucleotide, each A is adenosine, each G is guanosine, each s individually represents a phosphorothioate internucleotide linkage, U is 2′

    -deoxy-2′

    -C-allyl uridine, and B is an inverted deoxyabasic moiety.

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