3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents

• US 7,034,049 B1
• Filed: 05/05/2000
• Issued: 04/25/2006
• Est. Priority Date: 08/12/1999
• Status: Expired due to Fees

• Current Assignee: Pfizer Italia Srl (Pfizer Inc.)
• Original Assignee: Pharmacia Italia SPA (Pfizer Inc.), Pharmacia & Upjohn Company LLC (Pfizer Inc.)
• Inventors: Varasi, Mario, Pevarello, Paolo, Traquandi, Gabriella, Warpehoski, Martha A., Orsini, Paolo, Fritzen, Edward L., Brasca, Maria Grabriella, Pierce, Betsy S.
• Primary Examiner(s): Saeed, Kamal A.
• Assistant Examiner(s): Anderson, Rebecca
• Application Number:
  US10/048,486
• Time in Patent Office: 2,181 Days
• Field of Search: 548/372.5, 548/372.1, 548/248, 548/364.4, 548/364.7, 548/365.7, 544/355, 544/140, 544/371, 514/404, 546/275.4, 546/211
• US Class Current: 514/404
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/4155 non condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 13/08 of the prostate
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 33/00 Antiparasitic agents
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 231/16 Halogen atoms or nitro radicals
• CPC Class Codes: C07D 231/40 Acylated on said nitrogen atom
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 409/12 : linked by a chain containing hetero atoms as chain links

Abstract

Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C₃–C₆ cycloalkyl group optionally substituted by a straight or branched C₁–C₆ alkyl or arylalkyl group; R₁ is a straight or branched C₁–C₆ alkyl, C₂–C₄ alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl or arylalkenyl group, each of which may be optionally further substituted as indicated in the description; or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer, cell proliferative disorders, Alzheimer'"'"'s disease, viral infections, auto-immune diseases or neurodegenerative diseases.

Claims

1. A 3-amino-pyrazole derivative represented by formula (I):

wherein

R is a C₃–

C₆ cycloalkyl group optionally substituted by a straight or branched C₁–

C₆ alkyl or arylalkyl group;

R₁ is a phenylalkyl which may be optionally further substituted;

or a pharmaceutically acceptable salt thereof.

2. The 3-amino-pyrazole derivative of claim 1, wherein R is a C₃–

C₆ cycloalkyl group optionally substituted by a straight or branched C₁–

C₆ alkyl group;

R₁ is phenylalkyl, which is optionally substituted with one or more groups selected from the group consisting of cycloalkyl, hydroxy, alkylthio, alkoxy, amino, alkylamino, dialkylamino, alkoxycarbonylamino, alkoxycarbonylalkylamino, alkylcarbonyl, alkylsulphonyl, alkoxycarbonyl, carboxy, halogen, nitro, aryloxy, arylthio, arylsulphonyl, N-alkyl-piperazinyl, piperidinyl, 4-morpholinyl, arylamino, cyano, alkyl, aryl, oxo, haloaryl, haloarylalkyl, haloaryloxy, haloarylsulphonyl, aminosulphonyl, aminocarbonyl, arylcarbonyl, perfluorinated alkyl, and perfluorinated alkoxy groups;

or a pharmaceutically acceptable salt thereof.

3. The 3-amino-pyrazole of claim 1, wherein R is an unsubstituted C₃–

C₆ cycloalkyl group.

4. The 3-amino-pyrazole of claim 1, wherein R is cycloalkyl and R₁ is phenyl C₁–

C₆ alkyl.

5. The 3-amino-pyrazole of claim 3 or 4, wherein R is cyclopropyl.

6. The 3-amino-pyrazole of claim 1, wherein R₁ is optionally substituted in any of the free positions by one or more groups independently selected from:

halogen, nitro, oxo groups (C═

O), cyano, alkyl, perfluorinated alkyl, hydroxyalkyl, aryl, arylalkyl, heterocyclyl, cycloalkyl, hydroxy, alkoxy, perfluorinated alkoxy, aryloxy, heterocyclyloxy, methylenedioxy, alkylcarbonyloxy, arylcarbonyloxy, carboxy, alkoxycarbonyl, aryloxycarbonyl, cycloalkyloxycarbonyl, amino, ureido, alkylamino, dialkylamino, arylamino, diarylamino, formylamino, alkylcarbonylamino, arylcarbonylamino, heterocyclylcarbonylamino, alkoxycarbonylamino, alkoxyimino, alkylsulfonylamino, arylsulfonylamino, formyl, alkylcarbonyl, arylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, arylthio and alkylthio.

7. The 3-amino-pyrazole derivative of claim 1, which is selected from the group consisting of:

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2,2-diphenylacetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(4-nitrophenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-4-methoxybenzamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(3-methoxyphenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-[4-(dimethylamino)phenyl]acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-1-phenylcyclopropancarboxamide;

2-(1,3-benzodioxol-5-yl-N-(3-cyclopropyl-1H-pyrazol-5-yl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(4-methoxyphenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-phenylpropanamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(3,4-dimethoxyphenyl)acetamide;

2-(4-chlorophenyl)-N-(3-cyclopropyl-1H-pyrazol-5-yl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-4-oxo-4-phenylbutanamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-oxo-2-phenylacetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(4-methylphenyl)acetamide;

2-[1,1′

-biphenyl]-4-yl-N-(3-cyclopropyl-1H-pyrazol-5-yl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(3-chlorophenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-fluorophenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-chlorophenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(4-fluorophenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(4-trifluoromethyl-phenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-methoxy-2-phenylacetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-phenylacetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2,5-dimethoxyphenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-3-phenylpropanamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-[5-(2,6-difluorobenzyl)-2-methoxyphenyl]acetamide;

2-(4-bromophenyl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1-pyrrolidinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4¹-(hydroxymethyl)[1,1¹-biphenyl]-4-yl)acetamide;

N-5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3-thienyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4¹-fluoro[1,1,¹-biphenyl]-4-yl)acetamide;

4¹-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}[1.1¹-biphenyl]-4-carboxylic acid;

4¹-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxethyl}[1,1¹-biphenyl]-4-carboxamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4¹-formyl[1,1¹-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4¹-[(dimethylamino]methyl)[1,1¹-biphenyl]-4-yl}acetamide;

2-amino-N-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxethyl}phenyl)acetamide;

2-[4-aminomethyl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

2-[4′

-(aminomethyl)[1,1′

-biphenyl]-4-yl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4′

-[(methylamino)methyl][1,1′

-biphenyl]-4-yl}acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4′

-(1-pyrrolidinylmethyl)[1,1′

-biphenyl]-4-yl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4′

-(1-piperidinylmethyl)[1,1′

-biphenyl]-4-yl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4′

-(4-morpholinylmethyl)[1,1′

-biphenyl]-4-yl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4′

-[(4-methyl-1-piperazinyl)methyl][1,1′

-biphenyl]-4-yl}acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4′

-(1H-imidazol-2-yl)[1,1′

-biphenyl]-4-yl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-{[dimethylamino)carbonyl]amino}phenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4-[(methylsulfonyl)amino]phenyl}acetamide;

2-[4-(aminomethyl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

2-{4-[(acetylamino)methyl]phenyl}-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

2-[4-(aminosulfonyl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-oxo-1-pyrrolidinyl)phenyl]acetamide;

2-[1,1′

-biphenyl]-4-yl-N-(3-cyclopropyl-1H-pyrazol-5-yl)propanamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(4-phenoxyphenyl)acetamide;

2-[4-(acetylamino)phenyl]-N-(3-cyclopropyl-1H-pyrazol-5-yl)acetamide;

N-(4-{2-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-2-oxoethyl}phenyl)-1-pyrrolidinecarboxamide;

N-(4-{2-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-2-oxoethyl}phenyl)-1-piperidinecarboxamide;

N-(4-{2-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-2-oxoethyl}phenyl)-4-morpholinecarboxamide;

N-(4-{2-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-2-oxoethyl}phenyl)-4-methyl-1-piperazinecarboxamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-ethyl[1,1′

-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-propyl[1,1′

-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-hydroxy[1,1′

-biphenyl]-4-yl)acetamide;

2-(4′

-cyano[1,1′

-biphenyl]-4-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

2-(4′

-bromo[1,1′

-biphenyl]-4-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-propoxy[1,1′

-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-butoxy[1,1′

-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-pentoxy[1,1′

-biphenyl]-4-yl)acetamide;

4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}[1,1′

-biphenyl]-4-yl acetate;

2-(4′

-tert-butyl[1,1′

-biphenyl]-4-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

,4′

-dichloro[1,1′

-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-hydroxy[1,1′

-biphenyl]-4-yl)acetamide;

2-(3′

-bromo[1,1′

-biphenyl]-4-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

2-(3′

-amino[1,1′

-biphenyl]-4-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

2-(4′

-amino[1,1′

-biphenyl]-4-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}-N-[2-(1-pyrrolidinyl)ethyl][1,1′

-biphenyl]-4-carboxamide;

4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}-N-[2-(1-pyrrolidinyl)propyl][1,1′

-biphenyl]-4-carboxamide;

4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}-N-[2-(1-piperidinyl)ethyl][1,1′

-biphenyl]-4-carboxamide;

4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}-N-[2-(1-piperidinyl)propyl][1,1′

-biphenyl]-4-carboxamide;

4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}-N-[2-(4-morpholinyl)ethyl][1,1′

-biphenyl]-4-carboxamide;

4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}-N-[2-(4-morpholinyl)propyl][1,1′

-biphenyl]-4-carboxamide;

4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}-N-[2-(4-methyl-1-piperazinyl)ethyl][1,1′

-biphenyl]-4-carboxamide;

4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}-N-[2-(4-methyl-1-piperazinyl)propyl][1,1′

-biphenyl]-4-carboxamide;

(2S)-N-(3-cyclopropyl-1H-pyrazol-5-yl)-3,3,3-trifluoro-2-methoxy-2-phenylpropanamide;

(2S)-N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-methoxy-2-phenylethanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2,5-difluorophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-methylphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-hydroxyphenyl)acetamide;

(2S)-2-amino-N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-phenylethanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-nitrophenyl)propanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-hydroxy-3-methoxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[3,5-bis(trifluoromethyl)phenyl]lacetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-chloro-6-fluorophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4-[(2S)-2-aminopropanoyloxymethyl]phenyl}acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-bromomethylphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-methylsulphonylphenyl)acetamide;

(2R)-N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-methoxy-2-phenylethanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-methylphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3,5-dimethoxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3,4-difluorophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3,4-dichlorophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-bromophenyl)acetamide;

2-cyclohexyl-N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-phenylacetamide;

(1R)-2-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-2-oxo-1-phenylethyl acetate;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-hydroxy-2-diphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-methylsulfanylphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-bromophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-hydroxy-3-nitrophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-chloro-4-hydroxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-acetylamino-2-phenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-nitrophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-bromo-2-phenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-benzyloxy-3-methoxyphenyl)acetamide;

(2S)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-hydroxy-2-phenylethanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-trifluoromethylphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2,4-dichlorophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3,4-dihydroxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3,5-di-tert-butyl-4-hydroxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3,5-difluorophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-benzyloxycarbonyl-2-phenylacetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-butoxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-fluorophenyl)acetamide;

5-cyclohexyl 1-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}benzyl) 2-aminopentanedioate;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-isobutylphenyl)propanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-hydroxyphenyl)acetamide;

2-cyclopentyl-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-phenylacetamide;

(1S)-2-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-2-oxo-1-phenylethyl acetate;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-fluoro-2-phenylacetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-trifluoromethylphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-methoxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3,4,5-trimethoxyphenyl)acetamide;

2-chloro-2,2-bis(2-chlorophenyl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-hydroxy-2-(3-hydroxy-4-methoxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(pentafluorophenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-3-methyl-2-phenylpentamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-nitrophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-trifluoromethoxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-ethoxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-fluorophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-nitro-4-trifluoromethylphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2,6-dichlorophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2,4-dinitrophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-difluorophenylacetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-bromo-4-methoxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-3-hydroxy-2-phenylpropanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-fluoro-4-hydroxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-1-phenylcyclopropanecarboxamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2,6-difluorophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2,5-dihydroxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2,4,6-trimethylphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[2,5-bis(trifluoromethyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(5-methoxy-3-hydroxy-2-propylphenyl)acetamide;

N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-fluoro-[1,1′

-biphenyl]-4-yl)propanamide;

(2R)-N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-fluoro[1,1′

-biphenyl]-4-yl)propanamide;

;

2-{4-[(aminocarbonyl)amino]phenyl}-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

2-{4-[(2-amino-2-oxoethyl)amino]phenyl}-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

4-bromo-N-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)benzamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-iodophenyl)acetamide;

N-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)benzamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-hydroxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-methylsulfonaylaminophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-methylsulfonaylaminophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl}acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4-(2-amino-2-oxoethoxy)phenyl}acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4-[2-oxo-2-(1-pyrrolidinyl)ethoxy]phenyl}acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[3-(2-amino-2-oxoethoxy)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3-methoxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]hexanamide;

2-[1,1′

-biphenyl]-4-yl-N-(5-cyclopropyl-1H-pyrazol-3-yl)butanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1,3-dihydro-2H-isoindol-2-yl)phenyl]propanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]butanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-(2S)-2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(5-amino-4-phenyl-1H-1,2,3-triazol-1-yl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]pentanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-benzyloxyphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4-[(3,3-diethyl-4-oxo-2-azetidinyl)oxy]phenyl}acetamide;

2-[1,1′

-biphenyl]-4-yl-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-hydroxyacetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-3-bromo-2,2-diphenylpropanamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-hydroxy-5-isopropyl-2-methylphenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2,3,6-trifluorophenyl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-fluoro[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

-fluoro[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-fluoro[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-methoxy[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(pentafluoro[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-(trifluoromethoxy)[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-carboxy[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-formyl-4′

-methoxy[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-fluoro-3′

-methyl[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

,5′

-dichloro[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-acetyl[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-formyl[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

,5′

difluoro[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

,5′

-dimethyl[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

,6-difluoro[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-methoxy[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

,6-dimethyl[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(5′

-fluoro-2′

-methoxy[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

,5′

-dimethoxy[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

,6-dimethoxy[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-acetyl-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-ethoxy-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-((4′

-methylthio)-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-chloro-4′

-fluoro-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

-acetyl-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-ethyl-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-ethoxy-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

,4′

-dimethoxy-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

-ethoxy-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

,5′

-difluoro-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

,4′

-dimethoxy-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

,3′

-dimethyl-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-(trifluoromethoxy)[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

,4′

-difluoro-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-tert-butyl-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-acetamido[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-trifluoromethyl-[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-(hydroxymethyl)[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-nitro[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-(hydroxymethyl)[1,1′

-biphenyl]-4-yl)acetamide

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

-chloro-[1,1′

-biphenyl]-4-yl)acetamide

2-[4-(1,3-benzodioxol-5-yl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1-naphthyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-naphthyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-furyl)phenyl]acetamide;

2-[4-(5-acetyl-2-thienyl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

2-[4-(5-chloro-2-thienyl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(5-methyl-2-thienyl)phenyl]acetamide;

2-[4-(1-benzofuran-2-yl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-thienyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[3′

-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)[1,1′

-biphenyl]-4-yl)acetamide;

2-[4-(1-benzothien-2-yl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3-formyl-2-thienyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3-formyl-2-thienyl)phenyl]acetamide;

5-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}phenyl)-2-furoic acid;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3-methyl-1H-pyrazol-4-yl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3-furyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(5-formyl-3-thienyl)phenyl]acetamide;

[5-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}phenyl)-1H-indol-3-yl]acetic acid;

5-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}phenyl)tryptophan;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-pyridinyl)phenyl]acetamide;

1-acetyl-5-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}phenyl)-1H-indol-3-yl acetate;

2-[4-(2-amino-4-hydroxy-6-methyl-5-pyrimidinyl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(5-pyrimidinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(5-nitro-2-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(6-amino-3-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3-quinolinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(4-isoquinolinyl)phenyl]acetamide;

5-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}phenyl)nicotinic acid;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-amino-5-pyrimidinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(4-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(5-acetyl-2-thienyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(9H-purin-6-yl)phenyl]acetamide;

2-[4-(1-benzothien-3-yl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

5-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}phenyl)-1H-indol-3-yl acetate;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2,4-dimethoxy-5-pyrimidinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-chloro-3-thienyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(6-methyl-2-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1H-imidazol-5-yl)phenyl]acetamide;

2-[4-(6-amino-5-nitro-3-pyridinyl)phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2,3,5,6-tetrafluoro-4-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(4-methyl-2-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1H-pyrazol-4-yl)phenyl]acetamide;

5-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}phenyl)-2-thiophene acid;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(6-methoxy-2-pyridinyl)phenyl]acetamide;

6-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}phenyl)-2-pyridinecarboxylic acid;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2,4-dichloro-5-pyrimidinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(4-methyl-3-thienyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(5-formyl-2-furyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(6-nitro-3-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(8-quinolinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(5-methyl-2-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3-methyl-2-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1H-indol-7-yl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(6-methoxy-3-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-amino-9H-purin-6-yl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-methyl-1H-indol-5-yl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(6-fluoro-3-pyridinyl)phenyl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4′

-(ethylsulfanyl)[1,1′

-biphenyl]-4-yl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

,4′

-dimethyl[1,1′

-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-hydroxy[1,1′

-biphenyl]-4-yl)acetamide;

(2E)-3-(4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}[1,1′

-biphenyl]-3-yl)-2-propenoic acid;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[3′

-(trifluoromethyl)[1,1′

-biphenyl]-4-yl]acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-methyl[1,1′

-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[2′

-(methylsulfanyl)[1,1′

-biphenyl]-4-yl]acetamide;

4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}[1,1′

-biphenyl]-2-carboxylic acid;

3-(4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}[1,1′

-biphenyl]-4-yl)propanoic acid;

2-[4′

-(benzyloxy)[1,1′

-biphenyl]-4-yl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

,3′

-dichloro[1,1′

-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-isopropyl[1,1′

-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3-formyl-2-furyl)phenyl]acetamide;

(2E)-3-(4′

-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}[1,1′

-biphenyl]-4-yl)-2-propenoic acid;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{4′

-[(E)-2-nitroethenyl][1,1′

-biphenyl]-4-yl}acetamide;

2-(4′

-chloro[1,1′

-biphenyl]-4-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-methyl[1,1′

-biphenyl]-4-yl)acetamide;

2-(4′

-phenyl[1,1′

-biphenyl]-4-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4′

-phenoxy[1,1′

-biphenyl]-4-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2′

-formyl[1,1′

-biphenyl]-4-yl)acetamide;

2-(3′

-chloro-[1,1′

-biphenyl]-4-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(3′

-formyl[1,1′

-biphenyl]-4-yl)acetamide;

tert-butyl 2-(4-{2-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxoethyl}phenyl)-1H-pyrrole-1-carboxylate;

2-(3′

-cyano[1,1′

-biphenyl]-4-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide;

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-dibenzo[b,d]furan-4-ylphenyl)acetamide;

or a pharmaceutically acceptable salt thereof.

8. A pharmaceutical composition, comprising the 3-amino-pyrazole derivative of claim 1 and at least one pharmaceutically acceptable carrier and/or diluent.

9. A pharmaceutical composition according to claim 8 further comprising one or more chemotherapeutic agents.

10. A pharmaceutical composition comprising a compound of claim 1;

one or more chemotherapeutic agents; and

at least one pharmaceutically acceptable carrier and/or diluent.

11. A compound as defined in claim 1 for use as a medicament.