Method of identifying chemical compounds having selected properties for a particular application
First Claim
1. A method of identifying a molecule having selected properties for a particular application which comprises the steps of:
- a) forming a base module having at least two structural diversity elements by reacting a first compound having at least one structural diversity element and a first reactive group with a second compound having at least one structural diversity element and a second reactive group which is different from said first reactive group, wherein the first and second reactive groups combine by a solution phase addition reaction;
b) producing a first array of at least two different base modules by repeating step a) at least one time while varying at least one of the structural diversity elements of the first or second compounds to produce at least one additional base module having at least two structural diversity elements, at least one of which differs from the structural diversity elements of the base module produced in step a); and
c) simultaneously screening the first array of base modules in accordance with a standard determined by said particular application to identify a first suitable compound for the particular application.
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Abstract
A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diversity element and a first reactive group, with a second compound having at least one structural diversity element and a second reactive group, wherein the first and second groups combine by an addition reaction; producing a first array of molecules by varying at least one of the structural diversity elements of the compounds when producing the base modules; and screening the array to determine a first suitable compound for the particular application. The base modules are preferably formed form oxazolone- and aminimide-derived compounds. If desired, the method can be repeated by producing a second array of molecules through the formation of base modules having structural diversity elements that are modified from those of the first suitable compound; and screening the second array of molecules to determine a second suitable compound for the particular application. The second array producing and screening steps can be repeated as often as necessary to achieve an optimum compound for the particular application.
145 Citations
13 Claims
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1. A method of identifying a molecule having selected properties for a particular application which comprises the steps of:
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a) forming a base module having at least two structural diversity elements by reacting a first compound having at least one structural diversity element and a first reactive group with a second compound having at least one structural diversity element and a second reactive group which is different from said first reactive group, wherein the first and second reactive groups combine by a solution phase addition reaction; b) producing a first array of at least two different base modules by repeating step a) at least one time while varying at least one of the structural diversity elements of the first or second compounds to produce at least one additional base module having at least two structural diversity elements, at least one of which differs from the structural diversity elements of the base module produced in step a); and c) simultaneously screening the first array of base modules in accordance with a standard determined by said particular application to identify a first suitable compound for the particular application. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification