Electrically conductive polymers capable of being covalently grafted on by light, method for obtaining same and uses as supports in probes for specific identification in electronic biosensors

• US 7,034,164 B1
• Filed: 08/07/2000
• Issued: 04/25/2006
• Est. Priority Date: 08/12/1999
• Status: Expired due to Fees

• Current Assignee: Universite Joseph Fourier
• Original Assignee: Universite Joseph Fourier
• Inventors: Cosnier, Serge
• Primary Examiner(s): Solola, Taofiq
• Assistant Examiner(s): Shiao, Robert
• Application Number:
  US10/048,483
• Time in Patent Office: 2,087 Days
• Field of Search: 548/562
• US Class Current: 548/562
• CPC Class Codes: C07C 235/84 with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
• CPC Class Codes: C07D 207/333 Radicals substituted by oxygen or sulfur atoms
• CPC Class Codes: C07D 207/335 Radicals substituted by nitrogen atoms not forming part of a nitro radical
• CPC Class Codes: C07D 209/16 Tryptamines
• CPC Class Codes: C08G 61/122 derived from five- or six-membered heterocyclic compounds, other than imides
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/6825 Nucleic acid detection involving sensors
• CPC Class Codes: G01N 33/545 Synthetic resin

Abstract

The invention relates to new, inexpensive electropolymers capable of light-induced grafting, onto which specific identification probes can be easily grafted and having optimum capacity for interaction with the target analytes (DNA/DNA_c, PNA/PNA_c, enzyme/substrate/Antibody/Antigen).

These electropolymers capable of light-induced grafting are, for example, poly(pyrrole-benzophenone). Benzophenone forms sites for light-induced grafting.

The invention also covers the mono and oligomers which make up these novel electropolymers capable of light-induced grafting.

Another object of the invention is the process for their manufacture, as well as electronic biosensors containing these electropolymers capable of being grafted and/or grafted by probes for the analysis of biomolecules.

Claims

1. Pyrrolbenzophenone monomer of formula:

.