Bulk compounder manifold

• US 7,036,537 B2
• Filed: 02/01/2005
• Issued: 05/02/2006
• Est. Priority Date: 12/04/2003
• Status: Active Grant

• Current Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Original Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Inventors: Bartholomew, Joel, Raines, Kenneth C., DiGianfilippo, Aleandro, Steigerwalt, Jeffery, Pierce, Richard S.
• Primary Examiner(s): Walczak, David J.
• Assistant Examiner(s): DEVORE, PETER T
• Application Number:
  US11/048,154
• Publication Number:
  US 20050126652A1
• Time in Patent Office: 455 Days
• Field of Search: 141/10, 141/100, 141/104, 141/105, 141/285, 141/286, 141/301, 141/302, 141/313, 137/512.4, 137/605, 137/606, 604/83, 604/247
• US Class Current: 141/105
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/1475 Inlet or outlet ports
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61M 2039/1088 having a plurality of male connectors, e.g. Luer connectors
• CPC Class Codes: A61M 39/045 pre-slit to be pierced by blunt instrument
• CPC Class Codes: A61M 39/24 Check- or non-return valves
• CPC Class Codes: C12M 23/40 Manifolds; Distribution pieces fluid transfer means B01L3/563
• CPC Class Codes: Y10T 137/87684 Valve in each inlet

Abstract

The present invention provides a manifold for receiving fluid tubes in a bulk compounder. In its simplest form, the manifold includes a plurality of inlets, each inlet defining an opening to a respective fluid passageway, and each passageway contains a check-valve. Included in this manifold is an outlet in fluid communication with the fluid passageways and an inlet port which is coaxial with the outlet. The coaxial inlet port contains a check-valve. Included as a part of the present invention is a cannula adapted for use with the manifold of the present invention, tube sets for use with the manifold of the present invention, and a method of minimizing error in filling a bag using a manifold in accordance with the present invention.

Claims

1. A manifold for receiving fluid tubes in a bulk compounder, said manifold comprising:

a plurality of inlets, each inlet defining an opening to a respective fluid passageway, each said passageway containing a check valve;

a common flow channel in fluid communication with each said passageway;

an outlet in fluid communication with said common flow channel, said outlet comprising an outlet port having a self-sealing membrane adapted to be penetrated by a cannula; and

an inlet port which is coaxial with said outlet, said coaxial inlet port containing a check-valve.

2. The manifold of claim 1 further comprising a central chamber in fluid communication with each said fluid passageway for fluidly connecting said fluid passageways to said outlet.

3. The manifold of claim 1 wherein said outlet comprises an outlet port having a self-sealing membrane adapted to be penetrated by a cannula, and

wherein said coaxial inlet port check-valve is adapted to have a cracking pressure greater than the vacuum pressure within said outlet port when the cannula is pulled from said self-sealing membrane.

4. The manifold of claim 3 wherein all said check-valves are adapted to have a cracking pressure greater than the vacuum pressure within said outlet port when the cannula is pulled from said self-sealing membrane.

5. The manifold of claim 1 wherein said plurality of inlets are disposed linearly with respect to each other.

6. A manifold set for receiving fluid tubes in a bulk compounder comprising:

a manifold, said manifold comprising;

a plurality of inlets, each inlet defining an opening to a respective fluid passageway, each said passageway containing a check-valve;

a common flow channel in fluid communication with each said passageway;

an outlet having a self-sealing membrane, said outlet in fluid communication with said common flow channel said outlet comprising an outlet port having a self-sealing membrane adapted to be penetrated by a cannula;

an inlet port which is coaxial with said outlet, said coaxial inlet port containing a check-valve; and

a cannula having at least one male blunt tip for insertion into said self-sealing membrane.

7. The manifold set of claim 6 wherein said cannula has a female port at said male blunt tip end for receiving an additional male tip.

8. A tube set for use in bulk compounding, said tube set comprising:

a plurality of pump sections, each said pump section having a distal end;

a plurality of tubes, each said tube of said plurality having a distal end and proximal end, each said proximal end of each tube of said plurality attached to said distal end of a respective pump section, and each said distal end of each tube of said plurality attached to a manifold, said manifold comprising;

a plurality of inlets, each inlet defining an opening to a respective fluid passageway, each said passageway containing a check-valve;

a common flow channel in fluid communication with each said passageway;

an outlet in fluid communication with said common flow channel, said outlet comprising an outlet port having a self-sealing membrane adapted to be penetrated by a cannula; and

an inlet port which is coaxial with said outlet, said coaxial inlet port containing a check-valve.

9. The tube set of claim 8 wherein said plurality is six.

10. The tube set of claim 8 wherein said plurality is nine.

11. A tube set for use in bulk compounding, said tube set comprising:

a plurality of pump sections, each said pump section having a distal end and a proximal end;

a first plurality of tubes, each said tube of said first plurality attached to said proximal end of a respective pump section;

a second plurality of tubes, each said tube of said second plurality having a distal end and proximal end, each said proximal end of each tube of said second plurality attached to said distal end of a respective pump section, and said distal end of each tube of said second plurality attached to a manifold, said manifold comprising;

a plurality of inlets, each inlet defining an opening to a respective fluid passageway, each said passageway containing a check-valve;

a common flow channel in fluid communication with each said passageway;

an outlet in fluid communication with said common flow channel, said outlet comprising an outlet port having a self-sealing membrane adapted to be penetrated by a cannula; and

an inlet port which is coaxial with said outlet, said coaxial inlet port containing a check-valve.

12. The tube set of claim 11 wherein said first and second plurality are both six.

13. The tube set of claim 11 wherein said first and second plurality are both nine.

14. A method of minimizing error in the filling of a product bag in a bulk compounding system, said method comprising the steps of:

providing a manifold with a minimum common volume to minimize residual holding of any one ingredient solution, the manifold comprising a plurality of inlets, each inlet defining an opening to a respective fluid passageway containing a check-valve, a common flow channel in fluid communication with each said passageway, and an outlet in fluid communication with said common flow channel, said outlet comprising an outlet port having a self-sealing membrane adapted to be penetrated by a cannula; and

passing individual ingredient solutions through the manifold to fill a product bag;

whereby error is reduced because of the minimization of the manifold common volume step.