Ultrasonic imagining catheters

• US 7,037,269 B2
• Filed: 07/20/2001
• Issued: 05/02/2006
• Est. Priority Date: 07/20/2000
• Status: Expired due to Term

• Current Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Original Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Inventors: Howes, William, Wnendt, Stephan, Dickinson, Robert, Nix, Elvin
• Primary Examiner(s): Imam, Ali
• Application Number:
  US10/333,099
• Publication Number:
  US 20040102701A1
• Time in Patent Office: 1,747 Days
• Field of Search: 600407-472, 29/253.5, 736/25, 736/26, 310/334, 310/336, 128/916, 601/2, 601/3
• US Class Current: 600/459
• CPC Class Codes: A61B 1/00082 Balloons
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4488 the transducer being a phased array
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61M 2025/1093 having particular tip characteristics
• CPC Class Codes: A61M 25/104 used for angioplasty
• CPC Class Codes: Y10T 29/42 Piezoelectric device making
• CPC Class Codes: Y10T 29/49005 Acoustic transducer
• CPC Class Codes: Y10T 29/49124 On flat or curved insulated base, e.g., printed circuit, etc.
• CPC Class Codes: Y10T 29/4913 Assembling to base an electrical component, e.g., capacitor, etc.
• CPC Class Codes: Y10T 29/49155 Manufacturing circuit on or in base

Abstract

An intravascular ultrasonic imaging catheter is provided with a flexible circuit electrically coupled to a transducer array mounted on the distal end of the catheter, a portion of the flexible circuit being helically wound about the catheter in order to enhance the flexibility of the circuit. The catheter may be a balloon catheter which is also provided with a stent mounted on the balloon, the stent carrying one or more drugs designed to be eluted or washed into a patient'"'"'s blood stream after the stent has been delivered, by the balloon catheter, into a target area within the patient'"'"'s vascular system.

Claims

1. An apparatus for ultrasonic imaging, the apparatus comprising:

a catheter having a distal region;

an ultrasonic transducer array disposed at the distal region;

a flexible circuit electrically coupled to the transducer array for supplying electrical power to the array, wherein at least a portion of the flexible circuit is helically wound about the catheter; and

at least one multiplexer unit electrically coupled to the flexible circuit, and wherein the at least one multiplexer unit is proximal of the transducer array.

2. The apparatus of claim 1, wherein the portion of the flexible circuit that is helically wound about the catheter is adapted to enhance flexibility of the portion of the catheter carrying the flexible circuit.

3. The apparatus of claim 1, wherein the portion of the flexible circuit that is helically wound about the catheter is adapted to accommodate bending the portion of the catheter carrying the flexible circuit.

4. The apparatus of claim 1, wherein the flexible circuit is insulated.

5. The apparatus of claim 1, wherein the apparatus has a maximum external diameter of less than about 3 Fr.

6. The apparatus of claim 1, wherein the apparatus is adapted for passing within guiding catheters as small as 6 Fr.

7. The apparatus of claim 1, further comprising an imaging system coupled to the catheter.

8. The apparatus of claim 1, wherein the at least one multiplexer unit comprises a plurality of multiplexer units electrically coupled to the flexible circuit.

9. The apparatus of claim 1, wherein the helically wound portion of the flexible circuit is helically wound about the catheter between the ultrasonic transducer array and the at least one multiplexer units.

10. The apparatus of claim 1, further comprising an expandable balloon coupled to the catheter.

11. The apparatus of claim 10, wherein the balloon is coupled to the catheter proximal of the transducer array.

12. The apparatus of claim 11, further comprising a plurality of multiplexer units electrically coupled to the flexible circuit proximal of the balloon.

13. The apparatus of claim 12, wherein the helically wound portion of the flexible circuit is wound about the catheter between the ultrasonic transducer array and the multiplexer units.

14. The apparatus of claim 10, further comprising a stent coaxially disposed about the balloon.

15. The apparatus of claim 14, wherein the stent is crimped onto the balloon.

16. The apparatus of claim 15, wherein the helically wound portion of the flexible circuit is adapted to limit a minimum diameter to which the stent may be crimped.

17. The apparatus of claim 14, wherein the stent comprises a drug that is adapted to be eluted or washed from the stent into a patient'"'"'s blood stream when stent has been deposited at a target location within the patient.

18. The apparatus of claim 17, wherein the drug is applied to the stent as a coating.

19. The apparatus of claim 17, wherein the drug is lodged in interstices formed in the stent.

20. The apparatus of claim 17, wherein the stent carries a drug adapted to cause vasodilation.

21. The apparatus of claim 17, wherein the stent carries a drug adapted to cause one or more of:

inhibition of inflammation, immunosuppression, promotion of endothelial cell growth or inhibition of cell migration.

22. The apparatus of claim 17, wherein the stent carries a drug adapted to cause inhibition of cell proliferation.

23. The apparatus of claim 10, wherein a portion of the flexible circuit is disposed within the balloon.

24. The apparatus of claim 23, wherein the helically wound portion of the flexible circuit is disposed within the balloon.

25. The apparatus of claim 23, wherein the portion of the flexible circuit disposed within the balloon is adapted for exposure to inflation medium introduced into the balloon.

26. The apparatus of claim 23, wherein the portion of the flexible circuit disposed within the balloon is insulated.

27. A method of manufacturing the apparatus of claim 1, wherein the transducer array is first manufactured in a flat configuration and then formed into a cylindrical configuration.

28. An apparatus for ultrasonic imaging, the apparatus comprising:

a catheter having a distal region;

an ultrasonic transducer array disposed at the distal region;

a flexible circuit electrically coupled to the transducer array for supplying electrical power to the array, wherein at least a portion of the flexible circuit is helically wound about the catheter; and

a plurality of multiplexer units electrically coupled to the flexible circuit, wherein the multiplexer units are longitudinally spaced with respect to one another along the catheter.

29. The apparatus of claim 28, wherein the flexible circuit is helically wound about the catheter between the ultrasonic transducer array and at least one of the multiplexer units.