Polymer micelle as monolayer or layer-laminated surface

• US 7,037,517 B2
• Filed: 09/01/2003
• Issued: 05/02/2006
• Est. Priority Date: 11/04/1999
• Status: Expired due to Term

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: Kataoka, Kazunori, Nagasaki, Yukio, Emoto, Kazunori, Iijima, Michihiro
• Primary Examiner(s): Azpuru, Carlos A.
• Application Number:
  US10/470,574
• Publication Number:
  US 20050079195A1
• Time in Patent Office: 974 Days
• Field of Search: 424/423, 424/427, 424/428, 424/450, 623/6.11
• US Class Current: 424/427
• CPC Class Codes: A61F 2/14 Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
• CPC Class Codes: A61F 2/16 Intraocular lenses
• CPC Class Codes: A61F 2250/0056 differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence

Abstract

The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.

Claims

1. A method for delivering a guest molecule into an animal which comprises (a) incorporating said guest molecule onto the surface of a biomedical device or a polymeric micelle or into the biomedical device or said polymeric micelle, (b) coating said biomedical device with said polymeric micelle which incorporates the guest molecule or at least one polymeric micelle which is immobilized on the surface of the biomedical device, said polymeric micelle comprising either a hydrophobic outer shell and hydrophilic core or a hydrophilic outer shell or a hydrophobic inner shell, said polymeric micelle comprised of a block copolymer having a HLB value from about 1 to about 40, and (c) inserting said biomedical device into said animal, wherein said biomedical device is a contact lens or an intraocular lens.

2. The method according to claim 1 wherein the guest molecule is a drug.

3. The method according to claim 2 wherein the drug is a medicament useful for treating eye diseases.

4. The method according to claim 2 wherein the linkage of the drug to the biomedical device is biodegradable.

5. The method according to claim 3 wherein the eye disease is dry eye syndrome.

6. The method according to claim 1, wherein the release of the drug is attenuated.

7. A method for delivering a guest molecule into an animal which comprises

(a) incorporating said guest molecule on the surface of a biomedical device or polymeric micelle or into the biomedical device or said polymeric micelle, (b) coating said biomedical device with said polymeric micelle incorporating the guest molecule or at least one said polymeric micelle which is immobilized on the surface of the biomedical device, said polymeric micelle being multi-layered containing at least two layers, said first micelle layer comprising either a hydrophobic outer shell and hydrophilic core or a hydrophilic outer shell or a hydrophobic inner shell, and a second micelle layer comprising either a hydrophobic outer shell and hydrophilic core or a hydrophilic outer shell or a hydrophobic inner shell, each of said polymeric micelles comprised of a block copolymer having a HLB value from about 1 to about 40, and (c) inserting said biomedical device into said animal, wherein said biomedical device is a contact lens or an intraocular lens.

8. The method according to claim 7 wherein the biomedical device is a contact lens and the drug is a medicament useful for treating eye diseases.

9. The method according to claim 7 wherein the linkage of the drug to the biomedical device is biodegradable.

10. The method according to claim 8 wherein the eye disease is dry eye syndrome.

11. The method according to claim 7 wherein the polymeric micelle comprises at most six layers.

12. The method according to claim 7 wherein the release of the drug is attenuated.

13. The method according to claim 7 where in step (b) the biomedical device is coated with the polymeric micelle serially.