Indirect measurement of tissue analytes through tissue properties
First Claim
1. A method for noninvasive measurement of a target analyte in a tissue, comprising the steps of:
- collecting an analytical signal from the tissue, said collected signal comprising a tissue measurement;
extracting at least one spectral feature from the analytical signal indicative of the effect of the target analyte on the probed tissue; and
either correcting a direct analyte measurement based on said at least one feature;
orcalculating concentration of said analyte indirectly by application of a calibration model to said at least one feature.
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Abstract
Methods and system for noninvasive determination of tissue analytes utilize tissue properties as reflected in key features of an analytical signal to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured analytical signal of skin, leading to a biased noninvasive analyte measurement. Changes in the tissue properties are detected by identifying key features in the analytical signal responsive to physiological variations. Conditions not conducive to the noninvasive measurement are detected. Noninvasive measurements that are biased by physiological changes in tissue are compensated. In an alternate embodiment, the analyte is measured indirectly based on natural physiological response of tissue to changes in analyte concentration. A system capable of such measurements is provided.
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Citations
92 Claims
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1. A method for noninvasive measurement of a target analyte in a tissue, comprising the steps of:
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collecting an analytical signal from the tissue, said collected signal comprising a tissue measurement; extracting at least one spectral feature from the analytical signal indicative of the effect of the target analyte on the probed tissue; and either correcting a direct analyte measurement based on said at least one feature;
orcalculating concentration of said analyte indirectly by application of a calibration model to said at least one feature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A system for noninvasive measurement of a target analyte in a tissue, comprising:
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means for noninvasively collecting an analytical signal from said tissue, said collected signal comprising a tissue measurement; and means for measuring concentration of said analyte based on at least one spectral feature extracted from the analytical signal indicative of the effect of the target analyte on the probed tissue. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76)
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77. A method for noninvasive measurement of a target analyte in a tissue, comprising the steps of:
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collecting an analytical signal from the tissue, said collected signal comprising tissue measurement; extracting at least one feature from the analytical signal indicative of the effect of the target analyte on the probed tissue, wherein said effect comprises alteration of water distribution among body compartments; and either correcting a direct analyte measurement based on said at least one feature;
orcalculating concentration of said analyte indirectly by application of a calibration model to said at least one feature. - View Dependent Claims (78, 79, 80, 81)
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82. A method for noninvasive measurement of a target analyte in a tissue, comprising the steps of:
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collecting an analytical signal from the tissue, said collected signal comprising a tissue measurement; extracting at least one feature from the analytical signal indicative of the effect of the target analyte on the probed tissue wherein said at least one feature comprises at least a portion of a water band, a portion of a fat band, and a portion of a protein band; either correcting a direct analyte measurement based on said at least one feature;
orcalculating concentration of said analyte indirectly by application of a calibration model to said at least one feature. - View Dependent Claims (83, 84, 85, 86)
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87. A method for noninvasive measurement of a target analyte in a tissue, comprising the steps of:
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collecting an analytical signal from the tissue, said collected signal comprising a tissue measurement; preprocessing said tissue measurement; extracting at least one feature from the analytical signal indicative of the effect of the target analyte on the probed tissue; and either correcting a direct analyte measurement based on said at least one feature;
orcalculating concentration of said analyte indirectly by application of a calibration model to said at least one feature. - View Dependent Claims (88, 89, 90, 91, 92)
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Specification