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Closure-cap and container as a two-chamber cartridge for nebulizers for producing aerosols and active substance formulations, suitable for storage

  • US 7,040,311 B2
  • Filed: 03/11/2005
  • Issued: 05/09/2006
  • Est. Priority Date: 10/17/1998
  • Status: Expired due to Term
First Claim
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1. An apparatus comprising:

  • a container; and

    a closure-cap having;

    (i) a guide tube for passage of a capillary or cannula through the closure-cap, (ii) a connecting piece which at least partially enters the container through an upper edge of the container'"'"'s neck when the closure-cap is pushed onto the neck, (iii) a chamber integral within the connecting piece and including at least one opening, and (iv) a plunger disposed downward from the upper edge of the neck within the chamber and sealing the at least one opening thereof, the plunger including at least three sides defining a hollow space to hold one of a pharmaceutical concentrate and a pharmacologically acceptable liquid, and at least one aperture that is sealed when the plunger is in a first position and that opens when the plunger is in a second position, wherein;

    the pharmaceutical concentrate includes one or more active ingredients, selected from the group consisting of;

    betamimetics, anticholinergics, antiallergics, leukotriene antagonists and/or steroids, in a pharmacologically acceptable propellant-free liquid,a pharmaceutical formulation is formed in response to the plunger being in the second position and the pharmaceutical concentrate and the pharmacologically acceptable liquid combine.

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