Closure-cap and container as a two-chamber cartridge for nebulizers for producing aerosols and active substance formulations, suitable for storage
First Claim
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1. An apparatus comprising:
- a container; and
a closure-cap having;
(i) a guide tube for passage of a capillary or cannula through the closure-cap, (ii) a connecting piece which at least partially enters the container through an upper edge of the container'"'"'s neck when the closure-cap is pushed onto the neck, (iii) a chamber integral within the connecting piece and including at least one opening, and (iv) a plunger disposed downward from the upper edge of the neck within the chamber and sealing the at least one opening thereof, the plunger including at least three sides defining a hollow space to hold one of a pharmaceutical concentrate and a pharmacologically acceptable liquid, and at least one aperture that is sealed when the plunger is in a first position and that opens when the plunger is in a second position, wherein;
the pharmaceutical concentrate includes one or more active ingredients, selected from the group consisting of;
betamimetics, anticholinergics, antiallergics, leukotriene antagonists and/or steroids, in a pharmacologically acceptable propellant-free liquid,a pharmaceutical formulation is formed in response to the plunger being in the second position and the pharmaceutical concentrate and the pharmacologically acceptable liquid combine.
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Abstract
The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebulizer, as well as an active substance concentrate in which the active-substance is present as a solution or suspension for storage purposes.
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Citations
26 Claims
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1. An apparatus comprising:
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a container; and a closure-cap having;
(i) a guide tube for passage of a capillary or cannula through the closure-cap, (ii) a connecting piece which at least partially enters the container through an upper edge of the container'"'"'s neck when the closure-cap is pushed onto the neck, (iii) a chamber integral within the connecting piece and including at least one opening, and (iv) a plunger disposed downward from the upper edge of the neck within the chamber and sealing the at least one opening thereof, the plunger including at least three sides defining a hollow space to hold one of a pharmaceutical concentrate and a pharmacologically acceptable liquid, and at least one aperture that is sealed when the plunger is in a first position and that opens when the plunger is in a second position, wherein;the pharmaceutical concentrate includes one or more active ingredients, selected from the group consisting of;
betamimetics, anticholinergics, antiallergics, leukotriene antagonists and/or steroids, in a pharmacologically acceptable propellant-free liquid,a pharmaceutical formulation is formed in response to the plunger being in the second position and the pharmaceutical concentrate and the pharmacologically acceptable liquid combine. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An apparatus comprising:
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a container having a neck leading to a volume for storing a pharmacologically acceptable liquid; a closure cap including;
(i) a connecting piece which at least partially enters the volume through the neck when the closure-cap engages the container, (ii) a chamber integral within the connecting piece and including at least one opening at a lower end thereof, the chamber including a pharmaceutical concentrate including one or more active ingredients, selected from the group consisting of;
betamimetics, anticholinergics, antiallergics, leukotriene antagonists and/or steroids, in a pharmacologically acceptable propellant-free liquid; and
(iii) a guide tube extending through the closure cap to an upper end of the chamber;a plunger disposed downward from the neck and sealing an upper end of the chamber when in a first position, the plunger being movable by inserting a device through the guide tube; and a separating element sealing the opening at the lower end of the chamber, wherein movement of the plunger from the first position to a second position toward the lower end of the chamber breaks the seal by the separating element and permits the pharmaceutical concentrate to exit the chamber and combine with the pharmacologically acceptable liquid to form a pharmaceutical formulation in the volume of the container. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification