Method and apparatus for nitric oxide generation
First Claim
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1. An apparatus for delivering a therapeutic gas including nitric oxide comprising:
- a receptacle including a therapeutic gas outlet and a non-electrolytic nitric oxide precursor receiver; and
a transport gas inlet fluidly communicating from a source of a transport gas to the therapeutic gas outlet through the non-electrolytic nitric oxide precursor receiver,wherein the transport gas inlet includes a gas distributor in the non-electrolytic nitric oxide precursor receiver.
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Abstract
Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.
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Citations
41 Claims
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1. An apparatus for delivering a therapeutic gas including nitric oxide comprising:
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a receptacle including a therapeutic gas outlet and a non-electrolytic nitric oxide precursor receiver; and a transport gas inlet fluidly communicating from a source of a transport gas to the therapeutic gas outlet through the non-electrolytic nitric oxide precursor receiver, wherein the transport gas inlet includes a gas distributor in the non-electrolytic nitric oxide precursor receiver. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of delivering nitric oxide to a mammal comprising:
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non-electrolytically generating a therapeutic gas from a nitric oxide precursor that includes a precursor salt, wherein the therapeutic gas includes nitric oxide and is substantially devoid of nitrogen dioxide; and transporting the therapeutic gas to a mammal. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of delivering nitric oxide to a mammal comprising:
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non-electrolytically generating a therapeutic gas from a nitric oxide precursor, wherein the therapeutic gas includes nitric oxide and is substantially devoid of nitrogen dioxide; and transporting the therapeutic gas to a mammal, wherein non-electrolytically generating the therapeutic gas includes contacting the nitric oxide precursor with a buffer solution to form a mixture. - View Dependent Claims (27, 28, 29, 30)
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31. A method of delivering nitric oxide to a mammal comprising:
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non-electrolytically generating a therapeutic gas from a nitric oxide precursor, wherein the therapeutic gas includes nitric oxide and is substantially devoid of nitrogen dioxide; and transporting the therapeutic gas to a mammal, and controlling a flow rate of a transport gas through the precursor in the range of 1 to 20 liters per minute. - View Dependent Claims (32)
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33. A method of delivering nitric oxide to a mammal comprising:
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non-electrolytically generating a therapeutic gas from a nitric oxide precursor, wherein the therapeutic gas includes nitric oxide and is substantially devoid of nitrogen dioxide; and transporting the therapeutic gas to a mammal, and passing the therapeutic gas through a gas purifier prior to transporting the gas, wherein the gas purifier includes a ferrous salt.
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34. A method of delivering nitric oxide to a mammal comprising:
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non-electrolytically generating a therapeutic gas from a nitric oxide precursor, wherein the therapeutic gas includes nitric oxide and is substantially devoid of nitrogen dioxide; and transporting the therapeutic gas to a mammal, wherein generating the therapeutic gas includes contacting the nitric oxide precursor with a nitric oxide releasing salt. - View Dependent Claims (35)
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- 36. A kit comprising a nitric oxide precursor and instructional material describing generating and transporting a therapeutic gas comprising nitric oxide and being substantially devoid of nitrogen dioxide, wherein the nitric oxide precursor includes a precursor salt.
Specification