Method and apparatus for quantification of cardiac wall motion asynchrony
First Claim
1. A system, comprising:
- a curve generator adapted to generate first and second regional displacement curves based on magnitudes of cardiac regional wall displacement over a cardiac cycle length interval for first and second cardiac regions, respectively;
a curve offset module, coupled to the curve generator, to provide a common magnitude reference for the first and second regional wall displacement curves;
a curve averager, coupled to the curve offset module, to average each of the first and second regional displacement curves over a predetermined number of cardiac cycles;
a curve smoothing module, coupled to the curve averager, to smooth the averaged first and second regional displacement curves; and
a phase computer coupled to the curve smoothing module, the phase computer adapted to compute a relative phase representing a phase relationship between the first and second regional displacement curves based on a frequency analysis, the relative phase indicative of a cardiac wall motion asynchrony.
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Abstract
A phase analysis technique provides for quantification of regional wall motion asynchrony from endocardial border contours generated from two-dimensional echocardiographic ventricular images. The technique produces results including a degree of radial ventricular asynchrony in heart failure patients with ventricular conduction delay to predict a magnitude of contractile function improvement with pacing therapy. Quantification of change in ventricular regional wall motion asynchrony in response to a therapy provides for a means to identify candidates to receive the therapy and quantitatively predict the benefit of the therapy. Quantification of changes in ventricular regional wall motion asynchrony in response to a sequence of therapies provides for a means to determine an approximately optimal therapy for an intended patient response.
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Citations
20 Claims
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1. A system, comprising:
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a curve generator adapted to generate first and second regional displacement curves based on magnitudes of cardiac regional wall displacement over a cardiac cycle length interval for first and second cardiac regions, respectively; a curve offset module, coupled to the curve generator, to provide a common magnitude reference for the first and second regional wall displacement curves; a curve averager, coupled to the curve offset module, to average each of the first and second regional displacement curves over a predetermined number of cardiac cycles; a curve smoothing module, coupled to the curve averager, to smooth the averaged first and second regional displacement curves; and a phase computer coupled to the curve smoothing module, the phase computer adapted to compute a relative phase representing a phase relationship between the first and second regional displacement curves based on a frequency analysis, the relative phase indicative of a cardiac wall motion asynchrony. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification