Apparatus for treating prostate cancer and method for same

• US 7,041,121 B1
• Filed: 01/31/2003
• Issued: 05/09/2006
• Est. Priority Date: 01/31/2002
• Status: Active Grant

• Current Assignee: Project Trojan Intellectual Property Acquisition, LLC
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Williams, Stephen J., Lovewell, James G., McGaffigan, Thomas H.
• Primary Examiner(s): GIBSON, ROY DEAN
• Application Number:
  US10/356,226
• Time in Patent Office: 1,194 Days
• Field of Search: 607 88- 90, 607/92, 607/93, 604 19- 21, 606/15
• US Class Current: 607/89
• CPC Class Codes: A61N 2005/061 Bladder and/or urethra
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 5/067 using laser light

Abstract

A medical device for photodynamically treating cancerous tissue, such as prostate cancer, comprising a body, a needle extendable from the body and at least one light-emitting (e.g., laser) diode mounted on the needle. The body is sized and configured for introduction into the urethra of a patient. The needle is movable between a retracted position housed substantially within the cylindrical body, and a deployed position in which the needle extends from the cylindrical body to enable it to penetrate into prostate tissue. The light-emitting diode is adapted to emit light to activate a photosensitizing agent (e.g., porfimer sodium) in or adjacent cancerous tissue in the prostate. Methods of treating cancer and other embodiments of medical devices for cancer treatment are also disclosed.

Claims

1. A medical device for use in treating tissue in a mammalian body comprising a needle-like member having a distal portion adapted for introduction into the tissue of the body, plurality of laser diodes mounted on the distal portion of the needle-like member and extending helically around the needle-like member, and first and second electrical leads carried by the needle-like member for providing electrical energy to the at least one of the laser diodes.

2. The medical device of claim 1 wherein the needle-like member is a metal needle.

3. The medical device of claim 1 wherein the plurality of laser diodes extend along a length of the needle-like member.

4. A method for treating cancerous tissue in a mammalian body with porfimer sodium and a medical probe having a distal portion comprising the steps of introducing porfimer sodium into the body, introducing the medical probe into the body so that the distal portion is in the vicinity of the cancerous tissue and supplying light from the distal portion of the medical probe to activate the porfimer sodium in the vicinity of the cancerous tissue,

wherein the step of introducing porfimer sodium into the body includes the step of injecting the porfimer sodium into the body in the vicinity of the cancerous tissue,

wherein the injecting step includes the step of introducing a needle into the body and supplying the porfimer sodium through the needle to the cancerous tissue,

wherein the distal portion of the probe includes a needle-like member having an exterior surface and at least one light source mounted on the exterior surface, and

wherein the step of supplying light from the distal portion of the medical probe comprises supply light from the at least one light source.

5. A method for treating cancerous tissue in a mammalian body, the method comprising:

introducing into the body a photosensitizing agent that in response to absorbing light creates or increases an activity to destroy or inhibit cancerous tissue;

introducing a medical probe having a distal portion into the body such that the distal portion is in the vicinity of the cancerous tissue; and

supplying light from the distal portion of the medical probe to activate the photosensitizing agent to destroy or inhibit cancerous tissue,

wherein the cancerous tissue is located in a prostate, and the step of introducing a medical probe having a distal portion into the body such that the distal portion is in the vicinity of the cancerous tissue includes;

introducing the distal portion of a medical probe into the urethra; and

advancing a needle from the distal portion through the wall of the urethra into the prostate in the vicinity of the cancerous tissue, and

wherein the step of supplying light from the distal portion of the medical probe comprises supplying light from the needle.

6. The method of claim 5 in which the activity of the photosensitizing agent created or increased in response to absorbing light is selected from a group comprising:

emitting energy;

emitting energy at a different wavelength than the absorbed light;

inducing a photochemical effect;

inducing a thermal effect; and

eliciting a necrotic reaction and associated inflammatory response.

7. The method of claim 5 in which the pbotosensitizing agent comprises a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units.

8. The method of claim 5 in which the photosensitizing agent comprises porfimer sodium.

9. The method of claim 5 in which the step of introducing into the body a photosensitizing agent that absorbs light and emits sufficient energy to destroy or inhibit cancer cells includes:

intravenously administering the photosensitizing agent.

10. The method of claim 5 in which the step of introducing into the body a photosensitizing agent that absorbs light and emits sufficient energy to destroy or inhibit cancer cells includes:

injecting the photosensitizing agent in the vicinity of the cancerous tissue.

11. The method of claim 5 in which the step of supplying light from the needle to activate the photosensitizing agent so that it emits sufficient energy to destroy or inhibit cancerous tissue includes:

activating at least one laser diode located along the needle.

12. A medical device for photodynamically treating prostate cancer comprising:

a generally cylindrical body sized and configured for introduction into the urethra of a patient;

a needle movable between a retracted position housed substantially within the cylindrical body, and a deployed position in which the needle extends from the cylindrical body to enable it to penetrate into prostate tissue; and

at least one light-emitting diode mounted on the needle adapted to emit light to activate a photosensitizing agent in or adjacent cancerous tissue in the prostate.

13. The medical device of claim 12 in which the at least one light-emitting diode comprises a laser diode.

14. The medical device of claim 12 in which the at least one light-emitting diode comprises a plurality of light-emitting diode, the diodes being arranged along a flex circuit.

15. The medical device of claim 12 in which the needle is made of material that is able to flex as the needle is moved between the retracted and deployed positions.

16. The medical device of claim 12 wherein the needle is a metal needle.

17. The medical device of claim 12 wherein the at least one light-emitting diode includes a plurality of laser diodes extending along a length of the needle.

18. The medical device of claim 12 wherein the at least one light-emitting diode includes a plurality of laser diodes extending helically around the needle.

19. The medical device of claim 12 in which the needle, when in its deployed position, extends laterally from the body.

20. The medical device of claim 12 in which the needle comprises a plurality of needles deployed at different locations along the length or circumference of the body.