Detergent compositions comprising benefit agents

• US 7,041,793 B2
• Filed: 11/29/2001
• Issued: 05/09/2006
• Est. Priority Date: 12/22/1999
• Status: Expired due to Fees

• Current Assignee: Unilever Home & Personal Care USA (Unilever PLC)
• Original Assignee: Unilever Home & Personal Care USA (Unilever PLC)
• Inventors: Davis, Paul James, Parry, Neil James
• Primary Examiner(s): Rao, Manjunath N.
• Application Number:
  US09/998,660
• Publication Number:
  US 20020155972A1
• Time in Patent Office: 1,622 Days
• Field of Search: 435/183, 435/200, 435/209, 435/4, 435/6, 435/69.1, 435/86, 530/350, 436/86, 510/114, 510/392, 510/515
• US Class Current: 530/350
• CPC Class Codes: C07K 16/1275 from Streptococcus (G)
• CPC Class Codes: C07K 16/26 against hormones ; against hormone releasing or inhibiting factors
• CPC Class Codes: C07K 16/44 against material not provided for elsewhere , e.g. haptens, metals, DNA, RNA, amino acids
• CPC Class Codes: C07K 2317/22 from camelids, e.g. camel, llama or dromedary
• CPC Class Codes: C07K 2319/00 Fusion polypeptide
• CPC Class Codes: C11D 2111/12 Soft surfaces, e.g. textile
• CPC Class Codes: C11D 3/38 Products with no well-defined composition , e.g. natural products
• CPC Class Codes: C11D 3/3845 Antibodies
• CPC Class Codes: C12N 9/2437 Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
• CPC Class Codes: C12Y 302/01004 Cellulase (3.2.1.4), i.e. endo-1,4-beta-glucanase

Abstract

Detergent composition comprising fusion protein comprising a cellulose binding domain and a domain having a high binding affinity for another ligand. Preferably, the domain having a high binding affinity is directed at a Benefit Agent.

Claims

1. Detergent composition comprising:

a) a surfactant; and

b) a fusion protein comprising a cellulose binding domain and a domain having a high binding affinity for another ligand, with chemical equilibrium constant K_D for binding between the domain having the high binding activity and the ligand being lower than 10<sup>−

4</sup>M,

wherein the domain having a high binding affinity is an antibody or antibody fragment and,

wherein the domain having a high binding affinity binds to one of the following;

a benefit agent selected from the group consisting of softening agents, finishing agents/protective agents, fragrances, bleaching agents and dyes, a fabric, a specific part of the fabric, or micro-particles which are loaded with a benefit agent.

2. The detergent composition of claim 1, wherein the cellulose binding domain is obtained from a fungal enzyme isolated from fungi selected from the group consisting of Humicola, Trichoderma, Thermomonospora, Phanerochaete and Aspergillus or from a bacterial enzyme isolated from bacteria origin selected from the group consisting of Bacillus, Clostridimum, Streptomyces, Cellulomonas and Pseudomonas.

3. The detergent composition of claim 1, wherein the cellulose binding domain of the fusion protein is obtained from Trichoderma reesei.

4. The detergent composition of claim 1, wherein the antibody is a heavy chain antibody as found in Camelidae or obtained from V_h fragments by a camelization procedure.

5. The detergent composition of claim 1, wherein the benefit agent is selected from the group consisting of fabric softening agents, fragrances, perfumes, polymeric lubercants, photoprotective agents, latexes, resins, dye fixative agents, antioxidants, insecticides, soil repelling agents and soil release agents.

6. The detergent composition of claim 1, wherein the cellulose binding domain of the fusion protein is connected to the domain having a high binding affinity for another ligand by means of a linker consisting of 2–

15 amino acids.

7. The detergent composition of claim 1, wherein the antibody or the antibody fragment is multi-specfic.

8. Process for delivering a benefit agent to a fabric by treating the fabric with a composition comprising:

a) a fusion protein comprising a cellulose binding domain and a domain having a high binding affinity for another ligand, with chemical equilibrium constant K_D for binding between the domain having the high binding activity and the ligand being lower than 10<sup>−

4</sup>M,

wherein the domain having a high binding affinity is an antibody or antibody fragment and,

wherein the domain having a high binding affinity binds to one of the following;

a benefit agent, a fabric, a specific part of the fabric, or micro-particles which are loaded with a benefit agent; and

b) a benefit agent selected from the group consisting of softening agents, finishing agents/protective agents, fragrances and bleaching agents.